Modified release dosage forms
First Claim
1. A dosage form, comprising:
- a molded matrix, andat least one active ingredient at a level of more than about 20 weight percent,wherein the molded matrix comprises 10-100% of a thermal reversible carrier consisting of polyethylene glycol 3350,wherein the thermal reversible carrier is melted prior to being combined with the plurality of particles, wherein the plurality of particles are suspended in the molded matrix,wherein at least a portion of the plurality of particles are coated,wherein at least a portion of the coated particles comprise at least one active ingredient,wherein the coating provides modified release of the at least one active ingredient contained therein upon contacting of the dosage form with a liquid medium.
5 Assignments
0 Petitions
Accused Products
Abstract
In one embodiment a dosage form comprises at least one active ingredient and a molded matrix which comprises 10-100% of a material having a melting point of less than about 100 degrees C. selected from the stamp consisting of thermoplastic polyalkylene oxides, low melting hydrophobic materials, thermoplastic polymers, thermoplastic starches and combinations thereof, and the matrix is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium. The dosage form may additionally comprise uncoated particles which may contain at least one active ingredient. In another embodiment, a dosage form comprises at least one active ingredient, a plurality of particles and a molded matrix, wherein at least a portion of the particles are coated. The coated particles, the matrix or both may comprise at least one active ingredient, and the coated particles or the matrix or a combination thereof is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium.
238 Citations
6 Claims
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1. A dosage form, comprising:
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a molded matrix, and at least one active ingredient at a level of more than about 20 weight percent, wherein the molded matrix comprises 10-100% of a thermal reversible carrier consisting of polyethylene glycol 3350, wherein the thermal reversible carrier is melted prior to being combined with the plurality of particles, wherein the plurality of particles are suspended in the molded matrix, wherein at least a portion of the plurality of particles are coated, wherein at least a portion of the coated particles comprise at least one active ingredient, wherein the coating provides modified release of the at least one active ingredient contained therein upon contacting of the dosage form with a liquid medium. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification