IL-18 binding proteins
First Claim
1. An isolated binding protein capable of binding human IL-18, said binding protein comprising:
- an Ig constant heavy region having the amino acid sequence selected from the group consisting of;
SEQ ID NO;
2, and SEQ ID NO;
3;
an Ig constant light region having the amino acid sequence selected from the group consisting of;
SEQ ID NO;
4, and SEQ ID NO;
5;
an Ig variable heavy region having the amino acid sequence of SEQ ID NO;
6; and
an Ig variable light region having the amino acid sequence of SEQ ID NO;
7.
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Accused Products
Abstract
The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
128 Citations
64 Claims
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1. An isolated binding protein capable of binding human IL-18, said binding protein comprising:
-
an Ig constant heavy region having the amino acid sequence selected from the group consisting of;
SEQ ID NO;
2, and SEQ ID NO;
3;an Ig constant light region having the amino acid sequence selected from the group consisting of;
SEQ ID NO;
4, and SEQ ID NO;
5;an Ig variable heavy region having the amino acid sequence of SEQ ID NO;
6; andan Ig variable light region having the amino acid sequence of SEQ ID NO;
7. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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2. An isolated binding protein capable of binding human IL-18, said binding protein comprising:
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an Ig constant heavy region having the amino acid sequence of SEQ ID NO;
3;an Ig constant light region having the amino acid sequence of SEQ ID NO;
4;an Ig variable heavy region having the amino acid sequence of SEQ ID NO;
6; andan Ig variable light region having the amino acid sequence of SEQ ID NO;
7.
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33. An isolated binding protein comprising an antigen binding domain capable of binding human IL-18, wherein said antigen binding domain comprises a CDR-H1 having Residues 31-35 of SEQ ID NO.:
- 6;
a CDR-H2 having Residues 50-66 of SEQ ID NO.;
6;
a CDR-H3 having Residues 99-110 of SEQ ID NO.;
6;
a CDR-L1 having Residues 24-34 of SEQ ID NO.;
7;
a CDR-L2 having Residues 50-56 of SEQ ID NO.;
7; and
a CDR-L3 having Residues 89-98 of SEQ ID NO.;
7. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64)
- 6;
Specification