Devices to resist migration and rotation of implants used in brachytherapy and other radiation therapy

• US 7,972,261 B2
• Filed: 07/20/2006
• Issued: 07/05/2011
• Est. Priority Date: 07/22/2005
• Status: Expired due to Fees

• Current Assignee: Theragenics Corporation (Juniper Investment Co. LLC)
• Original Assignee: Biocompatibles UK Limited (Boston Scientific Corporation)
• Inventors: Matons, James, Rice, Warren, Johnston, Warren, Bouffard, Matthew, Lamoureux, Gary A.
• Primary Examiner(s): Marmor, II; Charles A
• Assistant Examiner(s): Burk; Catherine E
• Application Number:
  US11/489,895
• Publication Number:
  US 20070021642A1
• Time in Patent Office: 1,811 Days
• Field of Search: 600 1- 8
• US Class Current: 600/8
• CPC Class Codes: A61N 2005/1023 Means for creating a row of seeds, e.g. spacers
• CPC Class Codes: A61N 2005/1024 Seeds
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

An anchor mechanism includes a sleeve to fit around a structure such as a radioactive source, a thermal ablation implant, a spacer, a strand or a radiopaque marker. The sleeve has a bore that extends an entire longitudinal length of the sleeve, and through which the structure fits, such that the structure can extend out from both longitudinal ends of the sleeve. One or more protrusion extends from an outer surface of the sleeve to engage surrounding patient tissue after implantation of the structure into a patient, to thereby reduce a tendency for the structure to migrate and rotate after implantation.

Claims

1. An anchor mechanism adapted to reduce a tendency for a structure to migrate and rotate after implantation of the structure into a patient, where the structure is one or more of a radioactive source, a thermal ablation implant, a spacer, a strand and a radiopaque marker, the anchor mechanism comprising:

a sleeve adapted to fit around the structure;

said sleeve having a bore that extends an entire longitudinal length of said sleeve, and through which the structure fits, such that a portion of the structure extends out from each longitudinal end of said sleeve; and

two or more protrusions extending from an outer surface of said sleeve along at least a portion of the longitudinal length of said sleeve, said two or more protrusions each having a substantially squared profile formed by sidewalls extending along a portion of the longitudinal length and along a portion of a circumference of said sleeve, to form a space between said protrusions, at least along the longitudinal length of said sleeve, to receive surrounding patient tissue upon implantation of the structure into a patient, to thereby reduce a tendency for the structure to migrate and rotate after implantation;

wherein the sidewalls from adjacent protrusions that form the space along the longitudinal length of the sleeve are about parallel to each other and substantially perpendicular to the longitudinal axis of the sleeve;

wherein a thickness of said sleeve varies such that the thickness is greater where there are said two or more protrusions than where there is not a protrusion.

2. The anchor mechanism of claim 1, wherein an inner diameter of said sleeve is slightly smaller than an outer diameter of the structure so that an interference fit is provided therebetween.

3. The anchor mechanism of claim 1, wherein said sleeve is adapted to be heat shrunk to the structure.

4. The anchor mechanism of claim 1, wherein said sleeve is adapted to be adhered to the structure.

5. The anchor mechanism of claim 1, wherein said sleeve and said two or more protrusions are bioabsorbable.

6. The anchor mechanism of claim 1, wherein said sleeve and said two or more protrusions are biocompatible.

7. A therapeutic member for use in brachytherapy and other radiation treatment, comprising:

a structure that is one or more of a radioactive source, a thermal ablation implant, a spacer, a strand and a radiopaque marker;

a sleeve to fit around said structure;

said sleeve having a bore that extends an entire longitudinal length of said sleeve, and through which the structure fits, such that a portion of the structure extends out from each longitudinal end of said sleeve; and

two or more protrusions extending from an outer surface of said sleeve along at least a portion of the longitudinal length of said sleeve, said two or more protrusions each having a substantially squared profile formed by sidewalls extending along a portion of the longitudinal length and a portion of a circumference of said sleeve, to form a space between said protrusions, at least along the longitudinal length of said sleeve, to receive surrounding patient tissue upon implantation of the structure into a patient, to thereby reduce a tendency for the structure to migrate and rotate after implantation;

wherein the sidewalls from adjacent protrusions that form the space along the longitudinal length of the sleeve are about parallel to each other and substantially perpendicular to the longitudinal axis of the sleeve;

wherein a thickness of said sleeve varies such that the thickness is greater where there are said two or more protrusions than where there is not a protrusion.

8. The therapeutic member of claim 7, wherein said structure comprises said strand that includes a plurality of radioactive sources.

9. The therapeutic member of claim 7, wherein an inner diameter of said sleeve is slightly smaller than an outer diameter of said structure so that an interference fit is provided therebetween.

10. The therapeutic member of claim 7, wherein said sleeve is heat shrunk to said structure.

11. The therapeutic member of claim 7, wherein said sleeve is adhered to said structure.

12. The therapeutic member of claim 7, wherein said sleeve and said two or more protrusions are bioabsorbable.

13. The therapeutic member of claim 7, wherein said sleeve and said two or more protrusions are biocompatible.

14. A method for use in brachytherapy and other radiation treatment, comprising:

providing a structure that is one or more of a radioactive source, a thermal ablation implant, a spacer, a strand and a radiopaque marker;

fitting a sleeve around the structure such that a portion of the structure extends out from each longitudinal end of the sleeve, wherein the sleeve includes two or more protrusions extending from an outer surface of said sleeve along at least a portion of the longitudinal length of said sleeve, said two or more protrusions each having a substantially squared profile formed by sidewalls extending along a portion of the longitudinal length and along a portion of a circumference of said sleeve, to form a space between said protrusions, at least along the longitudinal length of said sleeve;

wherein the sidewalls from adjacent protrusions that form the space along the longitudinal length of the sleeve are about parallel to each other and substantially perpendicular to the longitudinal axis of the sleeve;

loading the structure, with the sleeve around the structure, into a hollow needle; and

using the hollow needle to implant the structure, with the sleeve around the structure, into patient tissue;

wherein the patient tissue is caught in the at least one said space upon implantation of the structure, with the sleeve around the structure, to thereby reduce a tendency for the structure to migrate and rotate at implantation; and

wherein a thickness of said sleeve varies such that the thickness is greater where there are said two or more protrusions than where there is not a protrusion.

15. An anchor mechanism to reduce a tendency for a structure to migrate and rotate after implantation of the structure into a patient, where the structure is at least one of a radioactive source, a thermal ablation implant, a spacer, a strand and a radiopaque marker, the anchor mechanism comprising:

a sleeve adapted to fit around the structure such that ends of the structure are not covered;

said sleeve having a bore that extends an entire longitudinal length of said sleeve;

two or more protrusions extending from an outer surface of said sleeve, said two or more protrusions each having a substantially squared profile formed by sidewalls extending along a portion of the longitudinal length and along a portion of a circumference of said sleeve;

one or more spaces formed by the two or more protrusions that extend along at least a portion of the longitudinal length of said sleeve; and

wherein the sidewalls from adjacent protrusions that form the space along the longitudinal length of the sleeve are about parallel to each other and substantially perpendicular to the longitudinal axis of the sleeve;

said sleeve adapted to be received upon an implantation site such that patient tissue is caught in the one or more spaces at implantation to thereby reduce a tendency for the structure to migrate and rotate at implantation;

wherein a thickness of said sleeve varies such that the thickness is greater where there are said two or more protrusions than where there is not a protrusion.