Application of biosensor chips

• US 7,972,494 B2
• Filed: 10/30/2006
• Issued: 07/05/2011
• Est. Priority Date: 11/09/2005
• Status: Active Grant

• Current Assignee: 138 East LCD Advancements Limited (Vector Capital Corporation)
• Original Assignee: Seiko Epson Corporation (Seiko Group)
• Inventors: Tam, Simon
• Primary Examiner(s): NOGUEROLA, ALEXANDER STEPHAN
• Application Number:
  US11/589,137
• Publication Number:
  US 20070102304A1
• Time in Patent Office: 1,709 Days
• Field of Search: 20440301-40315, 205/777.5, 205/778, 205/792, 422 55- 58
• US Class Current: 205/777.5
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001

Abstract

A method of sensing a property of each of a plurality of samples is disclosed. The method includes disposing a sensor chip in each sample, the sensor chip being adapted to sense the property of a respective sample and comprising sensing electronics, a wireless communication device and an identifier. Each sensor chip is then registered and sensed data is received from each of the registered sensor chips concurrently via the respective wireless communication device.

Claims

1. A method of sensing at least one property of each of a plurality of samples, the method comprising:

disposing at least one sensor chip in each sample, the at least one sensor chip being adapted to sense at least one property of a respective sample and comprising sensing electronics, a wireless communication device and an identifier;

registering each sensor chip, wherein upon registration, each sensor chip transmits via the wireless communication device of the sensor chip the at least one property that the sensor chip is adapted to sense; and

receiving sensed data from each registered sensor chip concurrently via the respective wireless communication device;

wherein;

at least one of said sensor chips is a biosensor chip, the biosensor chip being adapted to sense at least one of DNA, RNA, a gene sequence, a peptide and another biological molecule, and

the biosensor chip includes one or more potentiostat circuits.

2. A method according to claim 1, wherein a counter electrode is provided for each potentiostat circuit in a sample by applying a bias voltage to the sample.

3. A method of sensing at least one property of each of a plurality of samples, the method comprising:

disposing at least one sensor chip in each sample, the at least one sensor chip being adapted to sense at least one property of a respective sample and comprising sensing electronics, a wireless communication device and an identifier;

registering each sensor chip, wherein upon registration, each sensor chip transmits via the wireless communication device of the sensor chip the at least one property that the sensor chip is adapted to sense; and

receiving sensed data from each registered sensor chip concurrently via the respective wireless communication device;

wherein;

the sensor chip is used for sensing one or more properties of a sample using a redox reaction.

4. A method of sensing at least one property of each of a plurality of samples, the method comprising:

disposing at least one sensor chip in each sample, the at least one sensor chip being adapted to sense at least one property of a respective sample and comprising sensing electronics, a wireless communication device and an identifier;

registering each sensor chip, wherein upon registration, each sensor chip transmits via the wireless communication device of the sensor chip the at least one property that the sensor chip is adapted to sense;

receiving sensed data from each registered sensor chip concurrently via the respective wireless communication device; and

disposing a respective sample in a sensing area, the sensing area being adapted to control one or more predetermined conditions of the sample.

5. A method according to claim 4, wherein the sensing area includes at least one of a heater, a cooler, a temperature-controlled fluid bath, an agitator and a means for controlling flow of a fluid to be sampled over the sensor chips.

6. An apparatus for sensing at least one property of each of a plurality of samples concurrently, comprising:

a sensing area;

a wireless communication device, the wireless communication device comprising an antenna for wirelessly transmitting signals to and receiving signals from each of a plurality of sensor chips within the sensing area, each sensor chip being disposed in a respective sample, being adapted to sense at least one property of the respective sample and comprising sensing electronics, a sensor chip wireless communication device and an identifier;

a register for registering the identifier of each sensor chip, wherein upon registration, each sensor chip transmits the at least one property that the sensor chip is adapted to sense to the antenna via the sensor chip wireless communication device for registration; and

a sensed data processor for receiving and processing sensed data from each of the registered sensor chips concurrently via the sensor chip wireless communication devices;

wherein;

at least one of the plurality of sensor chips is a biosensor chip;

the sensed data relates to at least one of DNA, RNA, a gene sequence, a peptide and another biological molecule; and

the biosensor chip includes one or more potentiostat circuits.

7. An apparatus according to claim 6, wherein:

the apparatus is arranged to apply a bias voltage to a sample in which the biosensor chip is disposed to provide a counter electrode for each potentiostat circuit of the biosensor chip.

8. An apparatus for sensing at least one property of each of a plurality of samples concurrently, comprising:

a sensing area;

a wireless communication device, the wireless communication device comprising an antenna for wirelessly transmitting signals to and receiving signals from each of a plurality of sensor chips within the sensing area, each sensor chip being disposed in a respective sample, being adapted to sense at least one property of the respective sample and comprising sensing electronics, a sensor chip wireless communication device and an identifier;

a register for registering the identifier of each sensor chip, wherein upon registration, each sensor chip transmits the at least one property that the sensor chip is adapted to sense to the antenna via the sensor chip wireless communication device for registration; and

a sensed data processor for receiving and processing sensed data from each of the registered sensor chips concurrently via the sensor chip wireless communication devices;

wherein;

at least one sensor chip is used for sensing the at least one property of a sample during a redox reaction.

9. An apparatus for sensing at least one property of each of a plurality of samples concurrently, comprising:

a sensing area;

a wireless communication device, the wireless communication device comprising an antenna for wirelessly transmitting signals to and receiving signals from each of a plurality of sensor chips within the sensing area, each sensor chip being disposed in a respective sample, being adapted to sense at least one said property of the respective sample and comprising sensing electronics, a sensor chip wireless communication device and an identifier;

a register for registering the identifier of each sensor chip, wherein upon registration, each sensor chip transmits the at least one property that the sensor chip is adapted to sense to the antenna via the sensor chip wireless communication device for registration; and

a sensed data processor for receiving and processing sensed data from each of the registered sensor chips concurrently via the sensor chip wireless communication devices;

wherein;

the apparatus is adapted to control at least one condition of samples in the sensing area.

10. An apparatus according to claim 9, wherein the sensing area includes at least one of a heater, a cooler, a temperature-controlled fluid bath, an agitator and a means for controlling flow of a fluid to be sampled over the sensor chips.