Medical device applications of nanostructured surfaces

• US 7,972,616 B2
• Filed: 01/12/2006
• Issued: 07/05/2011
• Est. Priority Date: 04/17/2003
• Status: Active Grant

• Current Assignee: GLO Technologies LLC
• Original Assignee: Nanosys Incorporated (Shoei Electronic Materials, Inc.)
• Inventors: Bock, Lawrence A., Hardev, Veeral D., Daniels, R. Hugh, Niu, Chunming, Dubrow, Robert S., Sahi, Vijendra
• Primary Examiner(s): Weber; Jon P
• Assistant Examiner(s): SRIVASTAVA, KAILASH C
• Application Number:
  US11/330,722
• Publication Number:
  US 20060204738A1
• Time in Patent Office: 2,000 Days
• Field of Search: None
• US Class Current: 424/423
• CPC Class Codes: A61F 13/02 Adhesive bandages or dressings
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 2420/04 Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: Y10S 977/762 Nanowire or quantum wire, i.e. axially elongated structure having two dimensions of 100 nm or less
• CPC Class Codes: Y10S 977/764 with specified packing density
• CPC Class Codes: Y10S 977/773 Nanoparticle, i.e. structure having three dimensions of 100 nm or less
• CPC Class Codes: Y10S 977/811 Of specified metal oxide composition, e.g. conducting or semiconducting compositions such as ITO, ZnOx
• CPC Class Codes: Y10S 977/813 Of specified inorganic semiconductor composition, e.g. periodic table group IV-VI compositions
• CPC Class Codes: Y10S 977/90 having step or means utilizing mechanical or thermal property, e.g. pressure, heat
• CPC Class Codes: Y10S 977/904 for medical, immunological, body treatment, or diagnosis
• CPC Class Codes: Y10S 977/906 Drug delivery
• CPC Class Codes: Y10T 428/12111 Separated by nonmetal matrix or binder [e.g., welding electrode, etc.]
• CPC Class Codes: Y10T 428/249924 Noninterengaged fiber-containing paper-free web or sheet which is not of specified porosity
• CPC Class Codes: Y10T 428/29 Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof

Abstract

This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.

Claims

1. A wound dressing comprising:

a plurality of nanostructures; and

a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;

wherein at least a portion of the plurality of nanostructures include at least one coating material, wherein the nanostructures including the coating material are wholly or partially coated with the at least one coating material, and

wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.

2. The wound dressing of claim 1, wherein the nanostructures comprise nanowires, nanofibers, nanoparticles, nanodots, nanotetrapods, or nanotubes.

3. The wound dressing of claim 1, wherein the nanostructures comprise silicon oxide.

4. The wound dressing of claim 1, wherein the at least one coating material comprises a biocompatible polymer.

5. The wound dressing of claim 1, wherein the nanostructures include silicon nanowires coated with an oxide layer.

6. The wound dressing of claim 1, wherein at least a portion of the nanostructures comprise a material independently selected from the group consisting of silicon, glass, quartz, metals and metal alloys, inorganic polymers and copolymers, thermoset plastics, organic polymers including proteins, semiconductors, ceramics, TiO, ZnO, ZnS, ZnSe, ZnTe, CdS, CdSe, CdTe, HgS, HgSe, HgTe, MgS, MgSe, MgTe, CaS, CaSe, CaTe, SrS, SrSe, SrTe, BaS, BaSe, BaTe, GaN, GaP, GaAs, GaSb, InN, InP, InAs, InSb, PbS, PbSe, PbTe, AIS, AIP, AISb, Ge, SiGe, SiO, SiO₂, silicon carbide and silicon nitride.

7. The wound dressing of claim 1, wherein the at least one coating material includes a first coating material and a second coating material, wherein a first portion of the plurality of nanostructures is coated with the first coating material and a second portion of the plurality of nanostructures is coated with the second coating material.

8. The wound dressing of claim 1, wherein the at least one coating material includes fibrin.

9. The wound dressing of claim 1, wherein the at least one coating material includes fibrinogen.

10. The wound dressing of claim 1, wherein the at least one coating material includes an antibacterial coating material.

11. The wound dressing of claim 10, wherein the antibacterial coating material comprises silver, zinc, or titanium oxide.

12. The wound dressing of claim 1, wherein the at least one coating material includes a coating material which promotes wound healing.

13. The wound dressing of claim 1, wherein the at least one coating material includes a coating material which promotes cell growth.

14. The wound dressing of claim 1, wherein the at least one coating material includes at least one growth factor.

15. The wound dressing of claim 1, wherein the at least one coating material includes a hydrophobic coating material.

16. The wound dressing of claim 1, wherein the at least one coating material includes a flowable material.

17. The wound dressing of claim 1, wherein the at least one coating material includes an adhesive.

18. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have adhesive properties.

19. The wound dressing of claim 1, wherein the wound dressing is flexible.

20. The wound dressing of claim 1, wherein the wound dressing is air-penetrable.

21. The wound dressing of claim 1, wherein the wound dressing is water-repellent.

22. The wound dressing of claim 1, wherein the fibrous web is porous.

23. The wound dressing of claim 1, wherein the wound dressing adheres to both dry surfaces and wet surfaces.

24. The wound dressing of claim 1, wherein the wound dressing does not chemically bond to the biological tissue surface.

25. The wound dressing of claim 1, wherein the at least one coating material includes a coating material which prevents adhesion to a biological tissue surface.

26. The wound dressing of claim 1, wherein a surface of the bandage is capable of adhering to a biological tissue surface due to at least friction forces between at least a portion of the plurality of nanostructures and the biological tissue surface.

27. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures are curved or curled.

28. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures are bent, curved, curled, coiled.

29. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an average length of from about 1 nm to at least about 500 microns.

30. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an average length of from about 5 nm to at least about 1 micron.

31. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an average length of from about 10 microns to at least about 125 microns.

32. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an average length of from about 50 microns to at least about 100 microns.

33. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an average diameter of from about 5 nm to at least about 1 micron.

34. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an average diameter of from about 5 nm to at least about 500 microns.

35. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an average diameter of from about 20 nm to at least about 250 nm.

36. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an average diameter of from about 20 nm to at least about 200 nm.

37. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an average diameter of from about 40 nm to at least about 200 nm.

38. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an average diameter of from about 50 nm to at least about 150 nm.

39. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an average diameter of from about 75 nm to at least about 100 nm.

40. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an aspect ratio aspect ratio greater than one.

41. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an aspect ratio of 2 or greater.

42. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an aspect ratio greater than about 10.

43. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an aspect ratio greater than about 20.

44. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an aspect ratio greater than about 100.

45. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures have an aspect ratio greater than about 200.

46. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures comprise nanowires which have an aspect ratio greater than about 500.

47. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures comprise nanowires which have a substantially uniform diameter along the length of the nanowire.

48. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures comprise nanowires which have a non-uniform diameter along the length of the nanowire.

49. The wound dressing of claim 1, wherein a first portion of the plurality of nanostructures have a different size and/or shape than a second portion of the plurality of nanostructures.

50. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures protrude at least 10 nm above a first surface of the wound dressing.

51. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures protrude at least 100 nm above a first surface of the would dressing.

52. The wound dressing of claim 1, wherein the van der Waals forces comprise from about 0.1 N/cm² to about 100 N/cm².

53. The wound dressing of claim 1, wherein the van der Waals forces comprise from about 1.0 N/cm² to about 25 N/cm².

54. The wound dressing of claim 1, wherein the van der Waals forces comprise from about 2.0 N/cm² to about 10 N/cm².

55. The wound dressing of claim 1, wherein the density of contact points per unit area between one or more surfaces of the wound dressing and the biological tissue comprises from about 1 contact point per micron² of biological tissue surface to about 2000 contact points per micron² of biological tissue surface.

56. The wound dressing of claim 1, wherein the density of contact points per unit area between one or more surfaces of the wound dressing and the biological tissue comprises from about 50 contact points per micron² of biological tissue surface to about 250 contact points per micron² of biological tissue surface.

57. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures comprises an average density on one or more surfaces of the wound dressing from about 0.1 nanostructures per square micron to at least about 2,500 nanostructures per square micron.

58. The wound dressing of claim 1, wherein the plurality of nanostructures comprises an average density on one or more surfaces of the wound dressing from about 1 nanostructure per square micron to at least about 500 nanostructures per square micron.

59. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures comprises an average density on one or more surfaces of the wound dressing from about 10 nanostructures per square micron to at least about 250 nanostructures per square micron.

60. The wound dressing of claim 1, wherein at least a portion of the plurality of nanostructures comprises an average density on one or more surfaces of the wound dressing from about 50 nanostructures per square micron to at least about 100 nanostructures per square micron.

61. The wound dressing of claim 1, wherein the fibrous web includes a woven or non-woven fibrous mat.

62. The wound dressing of claim 4, wherein the biocompatible polymer is chosen from the group consisting of polyglycolic acid, poly-L-lactic acid, poly-DL-lactic acid, poly-D-lactic acid, poly(lactic acid-glycolic acid) copolymer, poly-epsilon-caprolactone, poly(glycolic acid-caprolactone) copolymer, polyamino acid, polyanhydride, polyorthoester, polycaprolactone, poly(lactide-co-glycolide), poly(hydroxybutyrate), poly(hydroxybutyrate-co-valerate), polydioxanone, poly(glycolic acid-co-trimethylene carbonate), polyphosphoester, polyphosphoester urethane, cyanoacrylates, poly(trimethylene carbonate), poly(iminocarbonate), polyalkylene oxalates, polyphosphazenes, hyaluronic acid, cellulose, starch, collagen, and copolymers and mixtures thereof.