Edible water-soluble film containing a foam reducing flavoring agent

• US 7,972,618 B2
• Filed: 09/20/2007
• Issued: 07/05/2011
• Est. Priority Date: 09/20/2006
• Status: Active Grant

• Current Assignee: Aquestive Therapeutics, Inc.
• Original Assignee: Monosol Rx LLC (Kuraray Company Limited)
• Inventors: Fuisz, Joseph M., Fuisz, Richard C., Myers, Garry L.
• Primary Examiner(s): Desai; Anand
• Assistant Examiner(s): MERCIER, MELISSA S
• Application Number:
  US11/858,214
• Publication Number:
  US 20080075825A1
• Time in Patent Office: 1,384 Days
• Field of Search: None
• US Class Current: 424/439
• CPC Class Codes: A23L 27/79 in the form of films
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence

Abstract

An edible water-soluble film is provided. The film includes at least one water-soluble polymer, and a foam reducing flavoring agent, wherein the film is free of added anti-foaming or defoaming agents.

Claims

1. A method of preparing an edible water-soluble film composition, said method comprising:

a) preparing a master batch of film-forming components comprising a water-soluble polymer, a foam reducing flavoring agent selected from the group consisting of menthol, cherry menthol, cinnamint, spearmint, peppermint, orange flavor, natural raspberry, and combinations thereof, and a polar solvent, wherein said foam reducing flavoring agent is added before mixing said polymer with said solvent;

b) mixing said film-forming components under vacuum;

c) wet casting said film-forming components; and

d) removing said polar solvent through a controlled drying process to form said edible water-soluble film;

wherein said film is free of added defoaming agents.

2. The method of claim 1, wherein the foam reducing flavoring agent is present in amount of about 0.1% to about 20% by weight of the film.

3. The method of claim 1, wherein the foam reducing flavoring agent is present in amount of about 0.5% to about 15% by weight of the film.

4. The method of claim 1, wherein said film composition further comprises an active agent.

5. The method of claim 1, wherein said foam reducing flavoring agent comprises menthol.