Porous biomaterials

• US 7,972,628 B2
• Filed: 10/01/2004
• Issued: 07/05/2011
• Est. Priority Date: 10/01/2003
• Status: Active Grant

• Current Assignee: University of Washington
• Original Assignee: University of Washington
• Inventors: Marshall, Andrew, Ratner, Buddy D.
• Primary Examiner(s): AZPURU, CARLOS A
• Application Number:
  US10/595,233
• Publication Number:
  US 20080075752A1
• Time in Patent Office: 2,468 Days
• Field of Search: None
• US Class Current: 424/499
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61L 27/14 Macromolecular materials
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system

Abstract

The invention provides porous biomaterials and methods for forming porous biomaterials. The porous biomaterials of the invention comprise a biocompatible polymer scaffold defining an array of pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all the pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores. The invention also provides implantable devices comprising a layer of a biomaterial, and methods for promoting angiogenesis in and around an implantable biomaterial.

Claims

1. A biomaterial, comprising a biocompatible polymer scaffold defining an array of pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all the pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores, wherein the biocompatible polymer scaffold comprises silicone rubber.

2. The biomaterial of claim 1, wherein the mean pore diameter is between about 30 and about 40 micrometers.

3. The biomaterial of claim 1, wherein the biocompatible polymer scaffold is a hydrogel.

4. The biomaterial of claim 1, wherein the biomaterial has a thickness of at least 70 micrometers.

5. An implantable device, comprising a layer of a biomaterial, wherein the biomaterial comprises a biocompatible polymer scaffold surrounding an array of monodispersed pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores, wherein the biocompatible polymer scaffold comprises silicone rubber.

6. The implantable device of claim 5, wherein the layer of biomaterial has a thickness of at least 70 micrometers.

7. The device of claim 5, wherein the device comprises a device body, wherein the layer of biomaterial is attached to the device body.

8. The device of claim 7, wherein the layer of biomaterial is attached to the outer surface of the device body.

9. The device of claim 7, wherein the device is a medical device.

10. A method for forming a biomaterial, comprising the steps of:

(a) forming a biocompatible polymer scaffold around a template comprising an array of monodisperse porogens, wherein substantially all the porogens have a similar diameter, wherein the mean diameter of the porogens is between about 20 and about 90 micrometers, wherein substantially all porogens are each connected to at least 4 other porogens, and wherein the diameter of substantially all the connections between the porogens is between about 15% and about 40% of the mean diameter of the porogens, wherein the biocompatible polymer scaffold comprises silicone rubber; and

(b) removing the template to produce a porous biomaterial.

11. The method of claim 10, wherein the porogens are spherical beads.

12. The method of claim 10, wherein the porogens comprise poly(methyl) methacrylate.

13. The method of claim 10, wherein the biomaterial has a thickness of at least 70 micrometers.

14. The method of claim 10, wherein step (a) comprises forming the template by packing the porogens into a mold and fusing the porogens to form the connections between the porogens.

15. The method of claim 14, wherein the porogens are fused by sintering.

16. A method for promoting angiogenesis in and around an implantable biomaterial, comprising the step of implanting a porous biomaterial, wherein the biomaterial comprises a biocompatible polymer scaffold surrounding an array of pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores, wherein the biocompatible polymer scaffold comprises silicone rubber.

17. A biomaterial, comprising a biocompatible polymer scaffold defining an array of pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all the pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores, wherein the biocompatible polymer scaffold comprises collagen.

18. An implantable device, comprising a layer of a biomaterial, wherein the biomaterial comprises a biocompatible polymer scaffold surrounding an array of monodispersed pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores, wherein the biocompatible polymer scaffold comprises collagen.

19. A method for forming a biomaterial, comprising the steps of:

(a) forming a biocompatible polymer scaffold around a template comprising an array of monodisperse porogens, wherein substantially all the porogens have a similar diameter, wherein the mean diameter of the porogens is between about 20 and about 90 micrometers, wherein substantially all porogens are each connected to at least 4 other porogens, and wherein the diameter of substantially all the connections between the porogens is between about 15% and about 40% of the mean diameter of the porogens, wherein the biocompatible polymer scaffold comprises collagen; and

(b) removing the template to produce a porous biomaterial.

20. A method for promoting angiogenesis in and around an implantable biomaterial, comprising the step of implanting a porous biomaterial, wherein the biomaterial comprises a biocompatible polymer scaffold surrounding an array of pores, wherein substantially all the pores have a similar diameter, wherein the mean diameter of the pores is between about 20 and about 90 micrometers, wherein substantially all pores are each connected to at least 4 other pores, and wherein the diameter of substantially all the connections between the pores is between about 15% and about 40% of the mean diameter of the pores, wherein the biocompatible polymer scaffold comprises collagen.