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Methods and compositions for the prevention and treatment of anemia

  • US 7,973,009 B2
  • Filed: 10/26/2007
  • Issued: 07/05/2011
  • Est. Priority Date: 10/23/1998
  • Status: Expired due to Fees
First Claim
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1. A method of raising and maintaining hematocrit in a mammal comprising administering an amount of an analog of human erythropoietin in a pharmaceutical composition effective to raise and maintain hematocrit, wherein the analog comprises the amino acid sequence of human erythropoietin from residues 1-165 as shown in SEQ ID NO:

  • 1 except for one or more amino acid changes which provide for one or more additional glycosylation site(s) as compared to human erythropoietin, wherein one additional site is introduced at position 52, 53, 55, 86 or 114 and an N-linked carbohydrate chain is attached at said one additional site.

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