Use of allopurinol for the treatment of palmar plantar erythrodysesthesia

• US 7,973,046 B2
• Filed: 05/31/2007
• Issued: 07/05/2011
• Est. Priority Date: 06/01/2006
• Status: Expired due to Fees

• Current Assignee: Nobera Pharma, S.L.
• Original Assignee: Nobera Pharma, S.L.
• Inventors: Rodemer, Yolanda
• Primary Examiner(s): Fetterolf; Brandon
• Assistant Examiner(s): Gembeh; Shirley V
• Application Number:
  US12/227,807
• Publication Number:
  US 20090306097A1
• Time in Patent Office: 1,496 Days
• Field of Search: 514/262.1
• US Class Current: 514/262.1
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/16 Emollients or protectives, e.g. against radiation
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

Allopurinol or a pharmaceutically acceptable salt thereof can be used for the treatment or prevention of palmar plantar erythrodysesthesia induced by chemotherapy. The allopurinol or its salt may be administered topically to the affected areas, palms and soles, preferably in the form of a cream.

Claims

1. A method for treating palmar plantar erythrodysesthesia (PPE) induced by fluoropyrimidine chemotherapy in a patient in need thereof comprising administering to the patient a medicament having an amount of allopurinol or a pharmaceutically acceptable salt thereof which is therapeutically effective to treat or prevent PPE induced by fluoropyrimidine chemotherapy.

2. The method of claim 1, wherein the PPE is induced by 5-fluorouracil chemotherapy.

3. The method of claim 2, wherein the medicament is administered topically to the skin.

4. The method of claim 3, wherein the medicament is administered topically to the skin of the hands or feet.

5. The method of claim 1, wherein the PPE is induced by capecitabine chemotherapy.

6. The method of claim 5, wherein the medicament is administered topically to the skin.

7. The method of claim 6, wherein the medicament is administered topically to the skin of the hands or feet.

8. The method of claim 1, wherein the medicament is administered topically to the skin.

9. The method of claim 8, wherein the medicament is administered topically to the skin of the hands or feet.