Techniques for applying, configuring, and coordinating nerve fiber stimulation

• US 7,974,693 B2
• Filed: 02/22/2005
• Issued: 07/05/2011
• Est. Priority Date: 08/31/2001
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: BioControl Medical (B.C.M) Ltd.
• Inventors: Cohen, Ehud, Ben-David, Tamir, Ayal, Shai, Ben-Ezra, Omry
• Primary Examiner(s): KAHELIN, MICHAEL WILLIAM
• Application Number:
  US11/064,446
• Publication Number:
  US 20050267542A1
• Time in Patent Office: 2,324 Days
• Field of Search: 607/17
• US Class Current: 607/17
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/4029 for evaluating the peripheral nervous systems A61B5/24 takes precedence
• CPC Class Codes: A61B 5/4041 Evaluating nerves condition
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/7217 of noise originating from a therapeutic or surgical apparatus, e.g. from a pacemaker
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

Apparatus is provided including an implantable sensor, adapted to sense an electrical parameter of a heart of a subject, and a first control unit, adapted to apply pulses to the heart responsively to the sensed parameter, the pulses selected from the list consisting of: pacing pulses and anti-arrhythmic energy. The apparatus further includes an electrode device, adapted to be coupled to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a right ventricle of the subject, and a jugular vein of the subject; and a second control unit, adapted to drive the electrode device to apply to the site a current that increases parasympathetic tone of the subject and affects a heart rate of the subject. The first and second control units are not under common control. At least one of the control units is adapted to coordinate an aspect of its operation with an aspect of operation of the other control unit. Other embodiments are also described.

Claims

1. A method for treating a subject in which a first control unit is implanted and configured to apply, from a first implantation site within the subject, only when a heart rate of the subject is within a first set of values, pulses to a heart of the subject responsive to a sensed electrical parameter of the heart, the pulses selected from the group consisting of:

pacing pulses and anti-arrhythmic energy, the method comprising;

configuring a second control unit to apply, at a second implantation site within the subject, only when the heart rate is within a second set of values, a current that increases parasympathetic tone of the subject and affects a heart rate of the subject, the second implantation site selected from the group consisting of;

a vagus nerve, an epicardial fat pad, a pulmonary vein, a carotid artery, a carotid sinus, a coronary sinus, a vena cava vein, a right ventricle, and a jugular vein; and

configuring at least one of the control units to coordinate an aspect of applying the pulses with an aspect of applying the current, wherein the first and second control units are not under common control,

wherein the first and second sets of values are non-overlapping.

2. The method according to claim 1, wherein configuring the second control unit to apply the current at the second implantation site comprises configuring the second control unit to apply the current responsively to the sensed electrical parameter.

3. The method according to claim 1, further comprising analyzing the parameter to detect arrhythmia of the subject, wherein configuring at least one of the control units to coordinate comprises configuring at least one of the control units to coordinate so as to reduce a likelihood that applying the current causes false detection of the arrhythmia.

4. The method according to claim 1, wherein the second implantation site is the vagus nerve, and wherein configuring the second control unit to apply the current comprises configuring the second control unit to apply the current to the vagus nerve.

5. The method according to claim 1, wherein configuring the second control unit to apply the current comprises configuring the second control unit to apply the current during at least one period selected from the group consisting of:

a refractory period of the heart, and a blanking period of the first control unit.

6. The method according to claim 1, wherein configuring the second control unit to apply the current comprises configuring the current to reduce the heart rate of the subject.

7. The method according to claim 1, wherein the second implantation site is the epicardial fat pad, and wherein configuring the second control unit to apply the current comprises configuring the second control unit to apply the current to the epicardial fat pad.

8. The method according to claim 1, wherein the first control unit comprises an implantable cardioverter defibrillator (ICD).

9. The method according to claim 1, wherein the first set of values includes values greater than 190 beats per minute and less than 60 beats per minute, and the second set of values includes values between 70 and 180 beats per minute.

10. The method according to claim 1, wherein configuring the at least one of the control units comprises configuring the first control unit or the second control unit to coordinate the aspect without communicating with the other control unit.

11. The method according to claim 1, wherein the first set of values includes values greater than 190 beats per minute and less than 60 beats per minute.

12. The method according to claim 1, wherein the second set of values includes values between 70 and 180 beats per minute.

13. The method according to claim 1, wherein configuring the at least one of the control units comprises configuring the first control unit to coordinate the aspect without communicating with the second control unit.

14. The method according to claim 1, wherein configuring the at least one of the control units comprises configuring the second control unit to coordinate the aspect without communicating with the first control unit.