Method and apparatus for quantification of cardiac wall motion asynchrony
First Claim
1. A system for use with an echocardiographic sensor and an echocardiographic machine adapted to record an echocardiogram, the system comprising:
- a controller including;
a therapy protocol synthesizer adapted to generate a sequence of therapy parameters; and
an automatic therapy protocol execution module adapted to time delivery of a sequence of therapies each using at least one parameter of the sequence of therapy parameters;
a therapy circuit, coupled to the controller, to deliver the sequence of therapies; and
a cardiac wall motion evaluation module adapted to receive the echocardiogram recorded by the echocardiographic machine during the delivery of the sequence of therapies and calculate parameters representative of degrees of cardiac wall motion asynchrony each associated with one therapy of the sequence of therapies based on a portion of the echocardiogram recorded during the delivery of the one therapy of the sequence of therapies;
wherein the cardiac wall motion evaluation module further comprises a therapy decision module coupled to the phase computer, the therapy decision module adapted to determine one or more approximately optimal pacing parameters based on the relative phase.
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Abstract
A phase analysis technique provides for quantification of regional wall motion asynchrony from endocardial border contours generated from two-dimensional echocardiographic ventricular images. The technique produces results including a degree of radial ventricular asynchrony in heart failure patients with ventricular conduction delay to predict a magnitude of contractile function improvement with pacing therapy. Quantification of change in ventricular regional wall motion asynchrony in response to a therapy provides for a means to identify candidates to receive the therapy and quantitatively predict the benefit of the therapy. Quantification of changes in ventricular regional wall motion asynchrony in response to a sequence of therapies provides for a means to determine an approximately optimal therapy for an intended patient response.
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Citations
34 Claims
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1. A system for use with an echocardiographic sensor and an echocardiographic machine adapted to record an echocardiogram, the system comprising:
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a controller including; a therapy protocol synthesizer adapted to generate a sequence of therapy parameters; and an automatic therapy protocol execution module adapted to time delivery of a sequence of therapies each using at least one parameter of the sequence of therapy parameters; a therapy circuit, coupled to the controller, to deliver the sequence of therapies; and a cardiac wall motion evaluation module adapted to receive the echocardiogram recorded by the echocardiographic machine during the delivery of the sequence of therapies and calculate parameters representative of degrees of cardiac wall motion asynchrony each associated with one therapy of the sequence of therapies based on a portion of the echocardiogram recorded during the delivery of the one therapy of the sequence of therapies;
wherein the cardiac wall motion evaluation module further comprises a therapy decision module coupled to the phase computer, the therapy decision module adapted to determine one or more approximately optimal pacing parameters based on the relative phase. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method, comprising:
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delivering a sequence of therapies; recording an echocardiogram during the delivery of the sequence of therapies; computing degrees of ventricular asynchrony each associated with one therapy of the sequence of therapies based on a portion of the echocardiogram recorded during the delivery of the one therapy of the sequence of therapies; and determining an approximately optimal therapy based on the computed degrees of ventricular asynchrony. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification