Closed-loop autonomic neuromodulation for optimal control of neurological and metabolic disease
First Claim
1. A system for modulation of the sympathetic nervous system in the treatment of disease, comprising:
- A. a signal conditioning circuit;
B. a sensor array in communication with said signal conditioning circuit;
C. a signal processor in communication with said signal conditioning circuit, wherein said signal processor performs neural state estimation;
D. a control circuit in communication with said signal processor and which calculates an output which is a function of the neural state;
E. an output stage circuit in communication with said control circuit; and
F. a stimulating electrode array, in communication with said output stage circuit, said stimulating electrode array configured to be in communication with a component of the sympathetic nervous system.
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Accused Products
Abstract
A neurological control system for modulating activity of any component or structure of some or all of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” This system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state or autonomic state and prevent neurological or metabolic signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals, with sensors configured to sense a particular characteristic indicative of a neurological, psychiatric, or metabolic condition.
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Citations
27 Claims
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1. A system for modulation of the sympathetic nervous system in the treatment of disease, comprising:
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A. a signal conditioning circuit; B. a sensor array in communication with said signal conditioning circuit; C. a signal processor in communication with said signal conditioning circuit, wherein said signal processor performs neural state estimation; D. a control circuit in communication with said signal processor and which calculates an output which is a function of the neural state; E. an output stage circuit in communication with said control circuit; and F. a stimulating electrode array, in communication with said output stage circuit, said stimulating electrode array configured to be in communication with a component of the sympathetic nervous system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 24, 25, 26, 27)
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13. A system for neural modulation in the treatment of obesity, comprising:
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A. a sensor array in communication with said signal conditioning circuit; B. a signal processor in communication with said sensor array, whereby said signal processor calculates at least one state; C. a control circuit in communication with said signal processor and which calculates an output which is a function of the neural state; D. an output stage circuit in communication with said control circuit; and E. a neuromodulator array, in communication with said output stage circuit, said neuromodulator array is configured to be in communication with a component of a sympathetic nervous system. - View Dependent Claims (14, 15, 16)
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17. A system for neural modulation in the treatment of metabolic disease, comprising:
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A. a sensor array in communication with said signal conditioning circuit; B. a signal processor in communication with said sensor array, whereby said signal processor calculates at least one state; C. a control circuit in communication with said signal processor and which uses a control law to calculate an output which is a function of the neural state; D. an output stage circuit in communication with said control circuit; and E. a neuromodulator array, in communication with said output stage circuit, said neuromodulator array is configured to be in communication with a component of a sympathetic nervous system. - View Dependent Claims (18, 19, 20)
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21. A system for modulation of the sympathetic nervous system in the treatment of disease, comprising:
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A. a signal conditioning circuit; B. a sensor array in communication with said signal conditioning circuit, said sensor array is configured to be in communication with a component of the sympathetic nervous system; C. a signal processor in communication with said signal conditioning circuit, wherein said signal processor performs neural state estimation; D. a control circuit in communication with said signal processor and which calculates an output which is a function of the neural state; E. an output stage circuit in communication with said control circuit; and F. a stimulating electrode array, in communication with said output stage circuit.
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22. A system for neural modulation in the treatment of obesity, comprising:
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A. a sensor array in communication with said signal conditioning circuit, said sensor array configured to be in communication with a component of a sympathetic nervous system; B. a signal processor in communication with said sensor array, whereby said signal processor calculates at least one state; C. a control circuit in communication with said signal processor and which calculates an output which is a function of the neural state; D. an output stage circuit in communication with said control circuit; and E. a neuromodulator array, in communication with said output stage circuit.
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23. A system for neural modulation in the treatment of metabolic disease, comprising:
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A. a sensor array in communication with said signal conditioning circuit, said sensor array configured to be in communication with a component of a sympathetic nervous system; B. a signal processor in communication with said sensor array, whereby said signal processor calculates at least one state; C. a control circuit in communication with said signal processor and which uses a control law to calculate an output which is a function of the neural state; D. an output stage circuit in communication with said control circuit; and E. a neuromodulator array, in communication with said output stage circuit.
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Specification