Nasal devices
First Claim
Patent Images
1. A method of delivering substance to a nasal airway of a subject, comprising the steps of:
- fitting a nosepiece to a nasal cavity of a subject, the nosepiece including a nozzle through which substance is delivered to the nasal airway, and at least one inflatable cuff member;
the subject exhaling through a mouthpiece unit to cause closure of the oropharyngeal velum of the subject;
inflating the at least one cuff member simultaneously with, or in response to, the subject exhaling through the mouthpiece unit; and
delivering substance through the nozzle of the nosepiece.
6 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to a nasal delivery device for and a method of delivering a substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.
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Citations
132 Claims
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1. A method of delivering substance to a nasal airway of a subject, comprising the steps of:
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fitting a nosepiece to a nasal cavity of a subject, the nosepiece including a nozzle through which substance is delivered to the nasal airway, and at least one inflatable cuff member; the subject exhaling through a mouthpiece unit to cause closure of the oropharyngeal velum of the subject; inflating the at least one cuff member simultaneously with, or in response to, the subject exhaling through the mouthpiece unit; and delivering substance through the nozzle of the nosepiece. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 32, 34)
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31. A method of delivering substance to a nasal cavity of a subject, comprising the steps of:
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fitting a nosepiece to a nasal cavity of a subject, the nosepiece including a nozzle through which substance is delivered to the nasal cavity, and at least one inflatable cuff member which is configured such as, when inflated, to provide a fluid-tight seal between the nosepiece and an inner wall of the nasal cavity of the subject; the subject exhaling through a mouthpiece unit to cause closure of the oropharyngeal velum of the subject; inflating the at least one cuff member simultaneously with, or in response to, the subject exhaling through the mouthpiece unit; and delivering substance through the nozzle of the nosepiece. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
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33. A method of delivering substance to a nasal airway of a subject, comprising the steps of:
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fitting a nosepiece to a nasal cavity of a subject, the nosepiece including a nozzle through which substance is delivered to the nasal airway, and at least one inflatable cuff member; the subject exhaling through a mouthpiece unit to cause closure of the oropharyngeal velum of the subject; providing a flow channel fluidly connecting the nosepiece and the mouthpiece unit, whereby exhaled air from an exhalation breath is delivered through the nosepiece inflating the at least one cuff member; and delivering substance through the nozzle of the nosepiece.
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56. A method of delivering substance to a nasal airway of a subject, comprising the steps of:
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fitting a nosepiece to a nasal cavity of a subject, the nosepiece including a nozzle through which substance is delivered to the nasal airway, and at least one cuff member, which includes at least one lobe, and which is configured such as, when fitted in the nasal cavity of the subject, to extend into a region of the nasal cavity of the subject and to engage an inner wall of the nasal cavity of the subject and direct at least a distal end of the nozzle towards a required site in the nasal airway of the subject; the subject exhaling through a mouthpiece unit to cause closure of the oropharyngeal velum of the subject; and delivering substance through the nozzle of the nosepiece. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85)
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86. A method of delivering substance to a nasal airway of a subject, comprising the steps of:
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fitting a nosepiece to a nasal cavity of a subject, the nosepiece including a nozzle through which substance is delivered to the nasal airway, and at least one cuff member, at least one of the at least one cuff member including at least one lobe which, when the at least one of the at least one cuff member is fitted in the nasal cavity of the subject, extends into a region of the nasal cavity of the subject such as to at least partially obstruct the same and prevent flow thereinto; the subject exhaling through a mouthpiece unit to cause closure of the oropharyngeal velum of the subject; and delivering substance through the nozzle of the nosepiece. - View Dependent Claims (87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122)
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123. A method of delivering substance to a nasal cavity of a subject, comprising the steps of:
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fitting a nosepiece to a nasal cavity of a subject, the nosepiece including a nozzle through which substance is delivered to the nasal cavity, and at least one inflatable cuff member which is configured such as, when inflated, to provide a fluid-tight seal between the nosepiece and an inner wall of the nasal cavity of the subject; the subject exhaling through a mouthpiece unit to cause closure of the oropharyngeal velum of the subject; providing a flow channel fluidly connecting the nosepiece and the mouthpiece unit, whereby exhaled air from an exhalation breath is delivered through the nosepiece; inflating the at least one cuff member; and delivering substance through the nozzle of the nosepiece.
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124. A method of delivering substance to a nasal airway of a subject, comprising the steps of:
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fitting a nosepiece to a nasal cavity of a subject, the nosepiece including a nozzle through which substance is delivered to the nasal airway, and at least one cuff member, which includes at least one lobe, and which is configured such as, when fitted in the nasal cavity of the subject, to extend into a region of the nasal cavity of the subject and to engage an inner wall of the nasal cavity of the subject and direct at least a distal end of the nozzle towards a required site in the nasal airway of the subject; the subject exhaling through a mouthpiece unit to cause closure of the oropharyngeal velum of the subject; providing a flow channel fluidly connecting the nosepiece and the mouthpiece unit, whereby exhaled air from an exhalation breath is delivered through the nosepiece; and delivering substance through the nozzle of the nosepiece.
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125. A method of delivering substance to a nasal airway of a subject, comprising the steps of:
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fitting a nosepiece to a nasal cavity of a subject, the nosepiece including a nozzle through which substance is delivered to the nasal airway, and at least one cuff member, which includes at least one lobe, and which is configured such as, when fitted in the nasal cavity of the subject, to extend into a region of the nasal cavity of the subject and to engage an inner wall of the nasal cavity of the subject and direct at least a distal end of the nozzle towards a required site in the nasal airway of the subject; the subject exhaling through a mouthpiece unit to cause closure of the oropharyngeal velum of the subject; and delivering substance through the nozzle of the nosepiece, wherein the substance comprises a powder. - View Dependent Claims (126)
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127. A method of delivering substance to a nasal airway of a subject, comprising the steps of:
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fitting a nosepiece to a nasal cavity of a subject, the nosepiece including a nozzle through which substance is delivered to the nasal airway, and at least one cuff member, which includes at least one lobe, and which is configured such as, when fitted in the nasal cavity of the subject, to extend into a region of the nasal cavity of the subject and to engage an inner wall of the nasal cavity of the subject and direct at least a distal end of the nozzle towards a required site in the nasal airway of the subject; the subject exhaling through a mouthpiece unit to cause closure of the oropharyngeal velum of the subject; and delivering substance through the nozzle of the nosepiece, wherein the substance comprises a liquid. - View Dependent Claims (128, 129, 130)
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131. A method of delivering substance to a nasal airway of a subject, comprising the steps of:
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fitting a nosepiece to a nasal cavity of a subject, the nosepiece including a nozzle through which substance is delivered to the nasal airway, and at least one cuff member, which includes at least one lobe, and which is configured such as, when fitted in the nasal cavity of the subject, to extend into a region of the nasal cavity of the subject and to engage an inner wall of the nasal cavity of the subject and direct at least a distal end of the nozzle towards a required site in the nasal airway of the subject; the subject exhaling through a mouthpiece unit to cause closure of the oropharyngeal velum of the subject; and delivering substance through the nozzle of the nosepiece, wherein the site includes at least a part of the olfactory region.
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132. A method of delivering substance to a nasal airway of a subject, comprising the steps of:
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fitting a nosepiece to a nasal cavity of a subject, the nosepiece including a nozzle through which substance is delivered to the nasal airway, and at least one cuff member, at least one of the at least one cuff member including at least one lobe which, when the at least one of the at least one cuff member is fitted in the nasal cavity of the subject, extends into a region of the nasal cavity of the subject such as to at least partially obstruct the same and prevent flow thereinto; the subject exhaling through a mouthpiece unit to cause closure of the oropharyngeal velum of the subject; providing a flow channel fluidly connecting the nosepiece and the mouthpiece unit, whereby exhaled air from an exhalation breath is delivered through the nosepiece; and delivering substance through the nozzle of the nosepiece.
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Specification