Use of multiple data points and filtering in an analyte sensor

• US 7,976,466 B2
• Filed: 06/01/2006
• Issued: 07/12/2011
• Est. Priority Date: 06/02/2005
• Status: Expired due to Fees

• Current Assignee: Konamite Limited
• Original Assignee: Isense Corporation
• Inventors: Jacobs, Peter G., Ward, W. Kenneth
• Primary Examiner(s): Mallari; Patricia C
• Application Number:
  US11/421,564
• Publication Number:
  US 20060281985A1
• Time in Patent Office: 1,867 Days
• Field of Search: 600/347, 600/365
• US Class Current: 600/365
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase

Abstract

Embodiments of the present invention improve the accuracy of measurements and/or in vivo calibrations of a biosensor by (1) using more than one sensor signal value and/or more than one directly sampled and measured value, such as a capillary blood glucose value, and/or by (2) delaying the acquisition of a sensor output value that is compared with a directly sampled and measured value, such as a capillary blood glucose value, during a calibration. In an embodiment of the present invention, the median of a series of measured values, or a median or mean of the medians, may be utilized to provide more consistent and accurate measurement data and/or to compensate for error or artifact.

Claims

1. A method of calibrating a biosensor that measures an analyte, comprising:

obtaining, by a computing device, a plurality of biosensor output signal values during a plurality of intervals;

determining, by the computing device, a median interval sensor output value for each of the plurality of intervals;

applying, by the computing device, a median filter to the median interval sensor output values to obtain a sensor output value representing a median value of the median interval sensor output values;

comparing, by the computing device, a blood analyte concentration with the sensor output value to obtain a sensor sensitivity value; and

utilizing, by the computing device, the sensor sensitivity value to calibrate signal output of the biosensor.

2. The method of claim 1, wherein at least one of the plurality of biosensor output signal values is obtained between 4 and 10 minutes after obtaining the blood analyte concentration.

3. The method of claim 1, wherein at least one of the plurality of biosensor output signal values is obtained about 5 minutes after obtaining the blood analyte concentration.

4. The method of claim 1, further comprising obtaining the blood analyte concentration by obtaining a blood sample via a fingerstick and using an external analyte meter to measure the blood analyte concentration of the blood sample.

5. The method of claim 4, wherein obtaining the blood analyte concentration comprises obtaining a plurality of blood analyte concentrations.

6. The method of claim 5, further comprising obtaining a sensor sensitivity value for each blood analyte concentration obtained, and wherein the sensor sensitivity values are temporally weighted.

7. The method of claim 1, wherein the signal output is displayed as a value on an electronic monitoring unit.

8. The method of claim 1, further comprising obtaining a value for a background current for the biosensor and subtracting, by the computing device, the background current value from the plurality of biosensor output signal values or from the median sensor output values prior to obtaining the sensor sensitivity value.

9. The method of claim 1, further comprising applying, by the computing device, a physiological filter to the plurality of biosensor output signal values.

10. The method of claim 1, wherein the biosensor comprises a glucose sensor.

11. The method of claim 1, wherein the analyte is glucose.

12. The method of claim 1, wherein the sensor sensitivity value is obtained by extrapolating, by the computing device, a line or curve to a fixed background current at zero glucose.

13. The method of claim 12, wherein the background current is calculated to be a fraction or multiple of the biosensor output signal values at zero glucose.

14. A method of sensing an analyte using a biosensor, comprising:

obtaining, by a computing device, a plurality of biosensor output signal values during a plurality of intervals;

determining, by the computing device, a median interval sensor output value for each of the plurality of intervals;

applying, by the computing device, a median filter to the median interval sensor output values to obtain a sensor output value representing a median value of the median interval sensor output values; and

displaying the sensor output value on an electronic monitoring unit coupled to the biosensor.

15. The method of claim 14, further comprising obtaining a value for a background current for the biosensor and subtracting, by the computing device, the background current value from the plurality of biosensor output signal values or from the sensor output value prior to displaying the sensor output value.

16. The method of claim 14, further comprising applying, by the computing device, a physiological filter to the plurality of biosensor output signal values.

17. The method of claim 14, wherein the biosensor comprises a glucose sensor.

18. The method of claim 14, wherein the analyte is glucose.