System and method for denaturing and fixing collagenous tissue
First Claim
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1. A method for modifying a valve in a subject'"'"'s body, comprising:
- endoluminally advancing an elongate flexible instrument to within a vicinity of a valve in a subject'"'"'s body;
heating a tissue mass located in a vicinity of the valve to a temperature sufficient to shrink the tissue mass, thereby modifying the shape or position of a valve to modify flow through the valve; and
introducing a biocompatible fixative into the tissue mass after heating the tissue mass, to retain shrinkage or tightening of the tissue mass and to retain the modified shape or position of the valve.
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Abstract
A method for modifying a geometry of a collagenous tissue mass includes heating the collagenous tissue mass to a temperature sufficient to cause denaturation, and introducing a biocompatible fixative, such as genepin, into the collagenous tissue mass.
548 Citations
16 Claims
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1. A method for modifying a valve in a subject'"'"'s body, comprising:
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endoluminally advancing an elongate flexible instrument to within a vicinity of a valve in a subject'"'"'s body; heating a tissue mass located in a vicinity of the valve to a temperature sufficient to shrink the tissue mass, thereby modifying the shape or position of a valve to modify flow through the valve; and introducing a biocompatible fixative into the tissue mass after heating the tissue mass, to retain shrinkage or tightening of the tissue mass and to retain the modified shape or position of the valve. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification