Electronic pipette

• US 7,976,793 B2
• Filed: 09/17/2004
• Issued: 07/12/2011
• Est. Priority Date: 11/27/2003
• Status: Active Grant

• Current Assignee: Gilson SAS
• Original Assignee: Gilson SAS
• Inventors: Remy, Philippe, Langlais, Christian, Solotareff, Stephane, May, Yves-Andre, Haddad, Patrick
• Primary Examiner(s): WARDEN, JILL ALICE
• Application Number:
  US10/944,532
• Publication Number:
  US 20050118069A1
• Time in Patent Office: 2,489 Days
• Field of Search: 422/501, 422/509, 738/633.2, 738/64, 738/640.1, 738/641.1, 738/641.3
• US Class Current: 422/501
• CPC Class Codes: B01L 2200/143 Quality control, feedback systems
• CPC Class Codes: B01L 2300/027 Digital display, e.g. LCD, LED
• CPC Class Codes: B01L 3/0217 of the plunger pump type medical syringes A61M
• CPC Class Codes: B01L 3/0237 Details of electronic control, e.g. relating to user interface
• CPC Class Codes: H01H 25/008 Operating part movable both angularly and rectilinearly, the rectilinear movement being perpendicular to the axis of angular movement
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

A system controls aspiration and dispensation of a liquid in a pipette. The system includes a computing device and the pipette. The computing device includes a pipetting module and a first communication interface. The pipetting module defines an operation to perform at the pipette. The first communication interface sends electronic signals to the pipette, the electronic signals defining the operation to perform at the pipette. The pipette includes a sampling tube, a piston assembly, a piston drive mechanism, a second communication interface, and a microprocessor. The piston assembly mounts to the sampling tube and includes a piston rod that fits within the sampling tube. The piston drive mechanism includes a control rod having a surface that contacts the piston assembly. The piston drive mechanism moves the piston rod of the piston assembly within the sampling tube thereby causing regulation of a liquid in the sampling tube. The second communication interface receives the electronic signals from the computing device. The microprocessor controls the piston drive mechanism and performs the operation defined by the electronic signals.

Claims

1. A device for aspirating and for dispensing liquid, the device comprising:

a sampling tube;

a piston assembly, the piston assembly mounted to the sampling tube and comprising a piston rod that fits within the sampling tube;

a piston drive mechanism, the piston drive mechanism comprising a control rod having a surface that contacts the piston assembly, the piston drive mechanism configured to move the piston rod of the piston assembly within the sampling tube thereby causing regulation of a liquid in the sampling tube;

a speed increase button;

a speed decrease button;

an aspirate/dispense button configured to cause aspiration or dispensation of liquid within the sampling tube when depressed;

an inversion button configured to cause, when depressed, operation of the aspirate/dispense button to invert from aspirate to dispense, or from dispense to aspirate;

a wireless communication interface, the wireless communication interface configured to receive electronic signals from a computing device that is not integral with the device;

a memory;

computer-executable instructions stored on the memory;

a microprocessor coupled to the wireless communication interface and operatively connected to the piston drive mechanism, the speed increase button, the speed decrease button, the aspirate/dispense button, and the inversion button, wherein the microprocessor is configured to process the received electronic signals and to;

control movement of the control rod responsive to the speed increase button to increase a speed selected to regulate the liquid, control movement of the control rod responsive to the speed decrease button to decrease a speed selected to regulate the liquid, and control movement of the control rod responsive to the aspirate/dispense button to cause the device to aspirate or dispense liquid;

a first operational mode button operatively connected to the microprocessor and configured to allow selection of one of a plurality of modes for operating the device;

a second operational mode button operatively connected to the microprocessor and configured to allow selection of one of the plurality of modes for operating the device; and

a display, wherein simultaneous depression of the first operational mode button and the second operational mode button causes the display to present a menu,

wherein the computer-executable instructions stored on the memory comprise instructions for each of the plurality of modes for operating the device, wherein one of the plurality of modes for operating the device is a program operational mode, and wherein, when the program operational mode is selected, the microprocessor executes stored computer-executable instructions and thereby causes the device to perform a sequence of pipette operations that have been organized on and communicated from the computing device not integral with the device.

2. The device of claim 1, wherein the communication interface is configured to send electronic signals to the user-computing device.

3. The device of claim 1, wherein the wireless communication interface is selected from the group consisting of an IEEE 802.11 interface and a Bluetooth interface.

4. The device of claim 1, wherein the received electronic signals comprise an instruction configured to cause performance of an operation selected from the group consisting of a serial number entry operation, a calibration operation, a production automation operation, a data transfer operation, an execute program operation, a new mode integration operation, and a servicing operation.

5. The device of claim 1, wherein the surface of the control rod is a non-flat surface.

6. The device of claim 5, wherein the non-flat surface is spherical in shape.

7. The device of claim 1 further comprising a thumb wheel, the thumb wheel comprising:

an axle;

a disc mounted to the axle in a manner allowing rotation of the disc about the axle in a plane of the device, the disc translatable in the plane of the device;

an encoder configured to generate a first signal to indicate a rotation of the disc about the axle; and

a motion detector configured to generate a second signal to indicate a translation of the disc in the plane of the device;

wherein the microprocessor is configured to receive the first signal and the second signal and to determine a user selection based on the received first signal and the received second signal.

8. The device of claim 7, wherein translation and rotation of the disc allows a user to make selections from the menu presented in the display.

9. The device of claim 8, wherein the menu allows the user to select a volume of liquid to regulate in the sampling tube.

10. The device of claim 7, wherein translation and rotation of the disc allows a user to set a parameter to a value presented in the display.

11. The device of claim 10, wherein the parameter is selected from the group consisting of a name, a number of cycles, a number of weeks, a date, an adjustment value, a quick readjustment value, a contrast, and a volume.

12. The device of claim 7, wherein the surface of the control rod is a non-flat surface.

13. The device of claim 1, wherein the received electronic signals comprise an instruction and further wherein the memory is further configured to store the instruction.

14. The device of claim 2, wherein the sent electronic signals comprise pipette data.

15. The device of claim 14, wherein the pipette data is selected from the group consisting of a device identification, a serial number, a version number, a date, a number of operations, a number of samplings, a target volume, a volume actually measured, a maximum volume, a minimum volume, a volume at 50% of the maximum volume, a volume limit, and a calibration parameter.

16. The device of claim 1, wherein the plurality of modes include an auto mode, an auto+mix mode, a manual mode, a repetitive mode, and the program operational mode.

17. The device of claim 1, further comprising a reset switch configured to cause a reset of the microprocessor.