Drug delivery to a joint
First Claim
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1. A method of intra-articular drug delivery, comprising:
- identifying an attachment zone in a synovial joint, wherein the attachment zone comprises a non-articulating portion of bone and/or cartilage within the synovial joint; and
percutaneously affixing a drug release device in the attachment zone, the drug release device comprising a base affixable in the attachment zone, a sustained-release drug carrier, and a drug, the device positioned so that the device releases the drug into the synovial fluid of the synovial joint, and so that agitation of the synovial fluid facilitates elution of the drug from the drug release device.
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Abstract
A method of intra-articular drug delivery may include selecting an attachment zone in a synovial joint; affixing a drug release device in the attachment zone, the drug release device comprising a base affixable in the attachment zone, a sustained-release drug carrier, and a drug, the device positioned so that the device releases the drug into the synovial fluid of the synovial joint, and so that agitation of the synovial fluid facilitates elution of the drug from the drug release device.
54 Citations
18 Claims
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1. A method of intra-articular drug delivery, comprising:
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identifying an attachment zone in a synovial joint, wherein the attachment zone comprises a non-articulating portion of bone and/or cartilage within the synovial joint; and percutaneously affixing a drug release device in the attachment zone, the drug release device comprising a base affixable in the attachment zone, a sustained-release drug carrier, and a drug, the device positioned so that the device releases the drug into the synovial fluid of the synovial joint, and so that agitation of the synovial fluid facilitates elution of the drug from the drug release device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of intra-articular drug delivery, comprising:
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identifying a para-articular attachment zone in a synovial joint, wherein the attachment zone comprises a non-articulating portion of bone and/or cartilage within the synovial joint; creating a void in the para-articular attachment zone; and percutaneously implanting in the void a drug-release means for sustainedly releasing a drug into the synovial fluid of the synovial joint.
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Specification