Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
First Claim
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1. A method for treating chronic otitis media and other bacterial ear conditions, which method comprises:
- a) applying an aqueous solvating system comprising a metal ion sequestering agent and greater than 0.2 wt. % cationic or zwitterionic surfactant to a bacterial biofilm comprising an extracellular polysaccharide matrix attached or adhered to at least a portion of the middle or inner ear,b) detaching, removing or otherwise disrupting at least a part of the biofilm by solvating the extracellular polysaccharide matrix with the solvating system, and thenc) rinsing away the solvating system.
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Abstract
Chronic otitis media and other bacterial ear conditions may be treated by applying a solvating system containing a metal ion sequestering agent and surfactant to a bacterial biofilm in the middle or inner ear. The solvating system disrupts the biofilm and aids in its removal.
159 Citations
46 Claims
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1. A method for treating chronic otitis media and other bacterial ear conditions, which method comprises:
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a) applying an aqueous solvating system comprising a metal ion sequestering agent and greater than 0.2 wt. % cationic or zwitterionic surfactant to a bacterial biofilm comprising an extracellular polysaccharide matrix attached or adhered to at least a portion of the middle or inner ear, b) detaching, removing or otherwise disrupting at least a part of the biofilm by solvating the extracellular polysaccharide matrix with the solvating system, and then c) rinsing away the solvating system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 46)
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14. A method for treating chronic otitis media and other bacterial ear conditions, which method comprises:
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a) applying an aqueous solvating system comprising a metal ion sequestering agent, a cationic or zwitterionic surfactant, and sufficient buffer so that the solvating system has a pH greater than 5 to a bacterial biofilm comprising an extracellular polysaccharide matrix attached or adhered to at least a portion of the middle or inner ear, b) detaching, removing or otherwise disrupting at least a part of the biofilm by solvating the extracellular polysaccharide matrix with the solvating system, and then c) rinsing away the solvating system. - View Dependent Claims (15, 16, 17, 18, 19, 44, 45)
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- 20. A solvating system comprising an aqueous composition containing a metal ion sequestering agent, greater than 0.2 wt. % cationic or zwitterionic surfactant, and an antimicrobial agent, and wherein the composition is on a biofilm comprising an extracellular polysaccharide matrix disposed on tissue within the middle or inner ear and contains sufficient metal ion sequestering agent and sufficient surfactant to solvate such an extracellular polysaccharide matrix.
- 34. A solvating system comprising an aqueous composition containing a metal ion sequestering agent, a cationic or zwitterionic surfactant and sufficient buffer so that the solvating system has a pH greater than 5, and wherein the composition is on a biofilm comprising an extracellular polysaccharide matrix disposed on tissue within the middle or inner ear and contains sufficient metal ion sequestering agent and sufficient surfactant to solvate such an extracellular polysaccharide matrix.
Specification