Endoprosthesis with select ceramic morphology

• US 7,976,915 B2
• Filed: 05/23/2007
• Issued: 07/12/2011
• Est. Priority Date: 05/23/2007
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Robaina, Samuel, Anand, Umang, Kuehling, Michael, Scheuermann, Torsten, Kokate, Jaydeep Y.
• Primary Examiner(s): Dye; Rena L
• Assistant Examiner(s): YAGER, JAMES C
• Application Number:
  US11/752,772
• Publication Number:
  US 20080294246A1
• Time in Patent Office: 1,511 Days
• Field of Search: 428/34.4, 428/34.7, 623/1.43, 623/1.4
• US Class Current: 428/34.4
• CPC Class Codes: A47G 19/22 Drinking vessels or saucers used for table service glass or drinking-vessel underlays A47G23/03 ; cups as travelling or camp articles A45F3/16; collapsible cups A45F3/20; cups made of plastics B65D1/265, made of paper B65D3/06; measuring cups G01F9/00
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: Y10T 428/131 Glass, ceramic, or sintered, fused, fired, or calcined metal oxide or metal carbide containing [e.g., porcelain, brick, cement, etc.]
• CPC Class Codes: Y10T 428/1321 Polymer or resin containing [i.e., natural or synthetic]

Abstract

An endoprosthesis, such as a stent, includes a ceramic, such as IROX, having a select morphology and composition.

Claims

1. An endoprosthesis, comprising:

a stent having an abluminal surface and an adluminal surface, the abluminal surface including a ceramic having a surface characterized by a first uniform morphology of defined grains with an aspect ratio of about 5;

1 or more, and the adluminal surface including another ceramic having a surface characterized by a second uniform morphology different from the first uniform morphology of the surface of the ceramic on the abluminal surface, the abluminal surface having a surface morphology different from a surface morphology of the adluminal surface, wherein the abluminal surface morphology is characterized by defined grains and the adluminal surface morphology is characterized by globular morphology.

2. The endoprosthesis of claim 1 wherein the aspect ratio is about 10:

1 to 20;

1.

3. The endoprosthesis of claim 1 wherein the grains have a length from about 50 nm-400 nm.

4. The endoprosthesis of claim 1 wherein the grains have a width of about 5 to 15 nm.

5. The endoprosthesis of claim 1 wherein the ceramic on the abluminal surface has a peak distance of about 200 nm or less.

6. The endoprosthesis of claim 1 wherein the ceramic on the abluminal surface has a peak height of about 400 nm or less.

7. The endoprosthesis of claim 1 wherein the ceramic on the abluminal surface has an Sdr of about 120 to 200.

8. The endoprosthesis of claim 1 wherein the ceramic on the abluminal surface has an Sq of about 20 or more.

9. The endoprosthesis of claim 1 further including a coating over the ceramic on the abluminal surface.

10. The endoprosthesis of claim 9 wherein the coating is formed of a polymer.

11. The endoprosthesis of claim 9 wherein the coating includes a drug.

12. The endoprosthesis of claim 1 wherein the ceramic on the abluminal surface is IROX.

13. An endoprosthesis comprising:

a stent having an abluminal surface and an adluminal surface, the abluminal surface including a ceramic having a surface characterized by a uniform morphology and an Sdr of about 100 or greater, and the adluminal surface including another ceramic having a surface characterized by another uniform morphology different from the uniform morphology of the surface of the ceramic of the abluminal surface, the abluminal surface having a surface morphology different from a surface morphology of the adluminal surface, wherein the abluminal surface morphology is characterized by defined grains and the adluminal surface morphology is characterized by globular morphology.

14. The endoprosthesis of claim 13 wherein said Sdr is about 120 to 200.

15. The endoprosthesis of claim 13 wherein said Sdr is about 150 or greater.

16. The endoprosthesis of claim 13 wherein said Sdr is about 180 or greater.

17. The endoprosthesis of claim 13 wherein said ceramic on the abluminal surface has an Sq of about 20 or more.

18. The endoprosthesis of claim 17 wherein said Sq is about 20 to 30.

19. The endoprosthesis of claim 13 wherein the Sdr has a uniformity of about +/−

20% or less.

20. The endoprosthesis of claim 13 wherein the ceramic on the abluminal surface includes defined grains having an aspect ratio of about 5:

1 or more.

21. The endoprosthesis of claim 20 wherein the aspect ratio is about 10:

1 to 20;

1.

22. The endoprosthesis of claim 20 wherein the grains have a length from about 50 nm-200 nm.

23. The endoprosthesis of claim 20 wherein the grains have a width of about 5 nm to 15 nm.

24. The endoprosthesis of claim 13 wherein the ceramic on the abluminal surface has a peak distance of about 400 nm or less.

25. The endoprosthesis of claim 13 wherein the ceramic on the abluminal surface has a peak height of about 400 nm or less.

26. The endoprosthesis of claim 13 further including a coating over the ceramic on the abluminal surface.

27. The endoprosthesis of claim 26 wherein the coating is formed of polymer.

28. The endoprosthesis of claim 26 wherein the coating includes drug.

29. The endoprosthesis of claim 13 wherein the ceramic on the abluminal surface is a coating on a metal.

30. The endoprosthesis of claim 13 wherein the ceramic on the abluminal surface is IROX.

31. An endoprosthesis, comprising:

a stent having an abluminal surface and an adluminal surface, the adluminal surface including a ceramic having a surface characterized by a uniform morphology of globular features having a peak height of about 20 nm or less, a diameter of about 100 nm or less, and a peak distance of about 200 nm or less, and the abluminal surface including another ceramic having a surface characterized by another uniform morphology different from the uniform morphology of the surface of the ceramic of the adluminal surface, the abluminal surface having a surface morphology different from a surface morphology of the adluminal surface, wherein the abluminal surface morphology is characterized by defined grains and the adluminal surface morphology is characterized by globular morphology.

32. The endoprosthesis of claim 31 wherein the ceramic on the adluminal surface has an Sq of about 10 or less.

33. The endoprosthesis of claim 31 wherein the ceramic on the adluminal surface has an Sdr of about 10 or less.

34. The endoprosthesis of claim 31 wherein the ceramic on the adluminal surface is exposed to tissue, free of an overcoat.

35. An endoprosthesis, comprising:

a stent having an abluminal surface and an adluminal surface, wherein

at least 25% of one of the adluminal surface and the abluminal surface is covered by a first ceramic having a surface characterized by a uniform morphology, the uniform morphology having an Sdr of about 10 or less and an Sdr uniformity of about +/−

10%, and

at least a portion of the other one of the adluminal surface and the abluminal surface is covered by a second ceramic having a surface characterized by another uniform morphology different from the uniform morphology of the surface of the first ceramic, the abluminal surface having a surface morphology different from a surface morphology of the adluminal surface, wherein the abluminal surface morphology is characterized by defined grains and the adluminal surface morphology is characterized by globular morphology.

36. An endoprosthesis, comprising:

a stent having an abluminal surface and an adluminal surface, the abluminal surface including a ceramic having a surface characterized by a first uniform morphology of defined grains and a polymer coating over the ceramic, and the adluminal surface including another ceramic having a surface characterized by a second uniform morphology different from the first uniform morphology of the surface of the ceramic on the abluminal surface, the abluminal surface having a surface morphology different from a surface morphology of the adluminal surface, wherein the abluminal surface morphology is characterized by defined grains and the adluminal surface morphology is characterized by globular morphology.

37. An endoprosthesis, comprising:

a stent having an abluminal surface and an adluminal surface, the abluminal surface including a ceramic coating having a surface characterized by an Sdr of about 1 or more and a polymer coating over the ceramic, and the adluminal surface including another ceramic having a surface characterized by a different morphology than the surface of the ceramic on the abluminal surface the abluminal surface having a surface morphology different from a surface morphology of the adluminal surface, wherein the abluminal surface morphology is characterized by defined grains and the adluminal surface morphology is characterized by globular morphology.

38. An endoprosthesis, comprising:

a stent having an abluminal surface and an adluminal surface, the abluminal surface including a first ceramic having a surface characterized by a uniform morphology of defined grains, and the adluminal surface including a second ceramic having a surface characterized by a uniform morphology of globular features, the abluminal surface having a surface morphology different from a surface morphology of the adluminal surface, wherein the abluminal surface morphology is characterized by defined grains and the adluminal surface morphology is characterized by globular morphology.

39. An endoprosthesis, comprising:

a stent having an abluminal surface and an adluminal surface, the adluminal surface including a first ceramic having a surface characterized by an Sdr of about 10 or less, and the abluminal surface including a second ceramic having a surface characterized by an Sdr of about 100 or more, the abluminal surface having a surface morphology different from a surface morphology of the adluminal surface, wherein the abluminal surface morphology is characterized by defined grains and the adluminal surface morphology is characterized by globular morphology.