Detection of pleural effusion using transthoracic impedance

• US 7,979,115 B2
• Filed: 01/10/2008
• Issued: 07/12/2011
• Est. Priority Date: 05/18/2005
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Stahmann, Jeffrey E., Hartley, Jesse W., Fogoros, Richard, Hatlestad, John
• Primary Examiner(s): Hindenburg; Max
• Assistant Examiner(s): SMITH, FANGEMONIQUE A
• Application Number:
  US11/972,405
• Publication Number:
  US 20080108907A1
• Time in Patent Office: 1,279 Days
• Field of Search: 600/547, 600/386, 600/538, 600/529, 607/17, 607/9
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/1116 Determining posture transitions
• CPC Class Codes: A61B 5/4869 Determining body composition
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36535 controlled by body position or posture

Abstract

This patent document discusses systems, devices, and methods for increasing a sensitivity or specificity of thoracic fluid detection in a subject and differentiating between pleural effusion and pulmonary edema. In one example, a thoracic impedance measurement circuit senses a thoracic impedance signal. In another example, a processor receives the thoracic impedance signal and determines whether such thoracic impedance signal is “significant.” A significant thoracic impedance signal indicates the presence of thoracic fluid and may be recognized by comparing the thoracic impedance signal (or variation thereof) to a thoracic impedance threshold. When a significant thoracic impedance signal is recognized, the processor is adapted to detect one or both of: a pleural effusion indication and a pulmonary edema indication using one or a combination of: physiologic information, patient symptom information, and posture information. In another example, the thoracic impedance threshold is adjusted using such physiologic, patient symptom, or posture information.

Claims

1. A system for the detection of fluid in a subject, comprising:

an implantable thoracic impedance measurement circuit, configured to sense a thoracic impedance signal from the subject;

a processor, coupled with the thoracic impedance measurement circuit to receive the thoracic impedance signal, the processor configured to detect a pleural effusion indication including a differential indication of pleural effusion relative to pulmonary edema using the thoracic impedance signal; and

an external user interface, coupled to the processor to receive information about the pleural effusion indication, the external user interface configured to provide a user-detectable lung fluid indication using information about the pleural effusion indication.

2. The system of claim 1, comprising at least one physiologic information device coupled to the processor, the physiologic information device configured to sense or collect physiologic information about the subject.

3. The system of claim 2, wherein the processor is configured to detect the pleural effusion indication using, at least in part, the physiologic information about the subject.

4. The system of claim 3, wherein the physiologic information about the subject includes at least one respiratory sound.

5. The system of claim 1, comprising at least one patient symptom device coupled to the processor, the patient symptom device configured to sense or collect patient symptom information about the subject.

6. The system of claim 5, wherein the processor is configured to detect the pleural effusion indication using, at least in part, the patient symptom information about the subject.

7. The system of claim 6, wherein the patient symptom information about the subject includes one or both of an indication of pleuritic chest pain or at least one hiccup.

8. The system of claim 1, comprising a posture sensor coupled to the processor, the posture sensor configured to sense a posture signal indicative of the subject'"'"'s then-current orientation.

9. The system of claim 8, wherein the processor is configured to detect the pleural effusion indication using, at least in part, a rate of change in the thoracic impedance signal associated with a change in the posture signal.

10. The system of claim 1, wherein the external user interface includes a user input device, the user input device configured to collect from a user one or a combination of physiologic information, patient symptom information, or posture information about the subject.

11. The system of claim 10, wherein the external user interface is configured to transmit the physiologic information, the patient symptom information, or the posture information to the processor for use in detecting the pleural effusion indication.

12. The system of claim 1, comprising a therapy control module configured to adjust or initiate a therapy using at least one of the pleural effusion indication or the user-detectable lung fluid indication.

13. A method for the detection of thoracic fluid in a subject, comprising:

sensing a thoracic impedance signal using an implantable device;

detecting a pleural effusion indication, including a differential indication of pleural effusion relative to pulmonary edema, using the thoracic impedance signal;

deriving a user-detectable lung fluid indication using information about the pleural effusion indication; and

providing the user-detectable lung fluid indication by way of an external user interface.

14. The method of claim 13, comprising sensing or receiving physiologic information about the subject, and using the physiologic information to detect the pleural effusion indication.

15. The method of claim 14, wherein sensing or receiving physiologic information about the subject includes sensing or receiving at least one respiratory sound.

16. The method of claim 13, comprising sensing or receiving patient symptom information about the subject, and using the patient symptom information to detect the pleural effusion indication.

17. The method of claim 16, wherein sensing or receiving patient symptom information about the subject includes sensing or receiving one or both of an indication of pleuritic chest pain or at least one hiccup.

18. The method of claim 13, comprising sensing or receiving a then-current posture orientation of the subject, and using information about a change in the thoracic impedance signal with a change in the posture orientation to detect the pleural effusion indication.

19. The method of claim 13, comprising filtering the thoracic impedance signal to obtain a near-DC thoracic impedance signal, and using the near-DC thoracic impedance signal to detect the pleural effusion indication.

20. The method of claim 13, comprising compensating the thoracic impedance signal to extract a blood resistivity-influenced component of the thoracic impedance signal, and using a blood resistivity-compensated thoracic impedance signal to detect the pleural effusion indication.

21. The method of claim 13, comprising providing a therapy to the subject in response to at least one of the pleural effusion indication or the user-detectable lung fluid indication.