Device and method for controlled delivery of active substance into the skin
First Claim
1. A flexible dermal patch having a top surface and a skin contacting bottom surface, the patch comprising:
- at least one negative electrode and at least one positive electrode for electrical coupling to the skin portion and/or skin appendage of a subject, wherein the at least one negative electrode and the at least one positive electrode are disposed substantially coplanar on the skin contacting bottom surface and a first electrode of the at least one negative electrode and the at least one positive electrode is disposed on a skin contacting side of the skin contacting bottom surface;
an internal flexible power source electrically coupled to the at least one negative electrode and the at least one positive electrode, wherein the flexible power source powers the patch and is disposed in or on the patch; and
at least one separator comprising a porous non-conductive material retaining a conductive fluid/composition therein, said at least one separator disposed on a second electrode of the at least one negative electrode and the at least one positive electrode, the at least one separator being for preventing contact between at least one of the at least one negative electrode and the at least one positive electrode and the skin portion, wherein the first electrode does not include a separator comprising a porous non-conductive material disposed thereon.
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Accused Products
Abstract
An apparatus for dermal treatment of an active substance having certain physical properties having a flexible, wearable patch conformable to the contour of a skin surface and having: a first electrode adapted to communicate the active substance into the skin by application of an electrical current on the skin surface, a second electrode capable of closing an electrical circuit with the skin surface, a power source for providing a current and voltage connected through a conductive media to the first and second electrode, and an apparatus for substantially controlling penetration depth of the active substance by selecting at least one variable from a plurality of variables.
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Citations
32 Claims
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1. A flexible dermal patch having a top surface and a skin contacting bottom surface, the patch comprising:
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at least one negative electrode and at least one positive electrode for electrical coupling to the skin portion and/or skin appendage of a subject, wherein the at least one negative electrode and the at least one positive electrode are disposed substantially coplanar on the skin contacting bottom surface and a first electrode of the at least one negative electrode and the at least one positive electrode is disposed on a skin contacting side of the skin contacting bottom surface; an internal flexible power source electrically coupled to the at least one negative electrode and the at least one positive electrode, wherein the flexible power source powers the patch and is disposed in or on the patch; and at least one separator comprising a porous non-conductive material retaining a conductive fluid/composition therein, said at least one separator disposed on a second electrode of the at least one negative electrode and the at least one positive electrode, the at least one separator being for preventing contact between at least one of the at least one negative electrode and the at least one positive electrode and the skin portion, wherein the first electrode does not include a separator comprising a porous non-conductive material disposed thereon. - View Dependent Claims (2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28, 29, 30, 31)
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5. A kit comprising:
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(a) a flexible dermal patch having a top surface and a skin contacting bottom surface, the patch comprising a power source and at least two substantially coplanar electrodes in electrical connection with the power source, the electrodes for electrical coupling with a skin portion and/or skin appendage of a subject, wherein the at least two electrodes are disposed on the skin contacting bottom surface and a first electrode of the at least two electrodes is disposed on a skin contacting side of the skin contacting bottom surface; and (b) at least one retainer comprising at least one separator comprising a porous non-conductive material for retaining a conductive fluid, the conductive fluid being for deposition on a second electrode of the at least two electrodes and/or topical application onto the skin portion and/or skin appendage of the subject, wherein the retainer is for disposing on the second electrode and for preventing contact between the second electrode and the skin portion, wherein the first electrode does not include a separator comprising a porous non-conductive material disposed thereon; the patch being designed and configured for delivering an electric current through the skin and the conductive fluid, for introduction of current and/or voltage to the skin portion and/or skin appendage, and/or transdermal or intradermal delivery of at least one substance. - View Dependent Claims (25, 32)
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Specification