Electronically-controlled device for release of drugs, proteins, and other organic or inorganic chemicals

• US 7,981,106 B2
• Filed: 02/25/2009
• Issued: 07/19/2011
• Est. Priority Date: 02/26/2008
• Status: Expired due to Fees

• Current Assignee: Pinchas Gilad
• Original Assignee: Pinchas Gilad
• Inventors: Gilad, Pinchas
• Primary Examiner(s): Sirmons; Kevin C
• Assistant Examiner(s): Bosques; Edelmira
• Application Number:
  US12/392,105
• Publication Number:
  US 20090216176A1
• Time in Patent Office: 874 Days
• Field of Search: 604/890.1, 604/892.1, 604/20, 604/501, 429/137
• US Class Current: 604/890.1
• CPC Class Codes: A61M 2205/0244 Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

A device for drug release including a drug reservoir including a gate, wherein opening of the gate releases a drug stored in the drug reservoir, an electronic command and control (C & C) unit in communication with the gate that produces a gate bias voltage and time profile supplied to the gate for controlling opening of the gate, and a power source for supplying power to the electronic command and control unit.

Claims

1. A device for drug release comprising:

a drug reservoir comprising a gate, wherein opening of said gate releases a drug stored in said drug reservoir;

an electronic command and control (C &

C) unit in communication with said gate that produces a gate bias voltage and time profile supplied to said gate for controlling opening of said gate; and

a power source for supplying power to said electronic command and control unit, wherein said gate comprises an external electrode formed with at least one exit pore, an internal electrode, an insulating layer that insulates between said external and internal electrodes, and a solid field enhancing member, which is closed to flow therethrough, that extends into said at least one exit pore, and wherein said insulating layer extends along rims of said electrodes, leaving a hollow volume between said electrodes.

2. The device according to claim 1, wherein said insulating layer and said internal and external electrodes are bonded together to form an enclosure impermeable to body fluids.

3. The device according to claim 1, wherein said field enhancing member is a rod.

4. The device according to claim 1, wherein said field enhancing member is a cone.

5. The device according to claim 1, wherein said gate further comprises an additional electrode located below said gate and said internal electrode, and insulated from said gate and said internal electrode by an insulating layer.

6. The device according to claim 1, wherein said at least one exit pore has a diameter from 200 nm to 5 micrometers.

7. The device according to claim 5, wherein said internal electrode and said additional electrode are each formed with at least one feed hole larger in diameter than said at least one exit pore.

8. The device according to claim 7, wherein said at least one feed hole has a diameter of 10-50 microns.

9. The device according to claim 1, wherein said electronic C &

C unit comprises a charging element for said power-source and a communication circuit tuned to said external C &

C unit.

10. The device according to claim 1, wherein said electronic C &

C unit is programmable to provide a delivery routine in accordance with an individual patient response.

11. The device according to claim 1, wherein said gate operates as a reversible pump, wherein a first polarity of said gate bias voltage causes ejection of molecules from said drug reservoir, and a second polarity of said gate bias voltage causes molecules external to said drug reservoir to be sucked into said drug reservoir.

12. The device according to claim 1, wherein said gate bias voltage suppresses molecular flow of fluids into said device.

13. The device according to claim 5, wherein said additional electrode has voltages applied thereto separately relative to said external and internal electrodes.

14. The device according to claim 4, wherein equipotential lines curve around said cone thereby producing electric field enhancement, and no equipotential lines extend outside said gate.

15. The device according to claim 1, wherein said field enhancing member is electrically connected to said internal electrode.