Outer eyelid heat and pressure treatment for treating meibomian gland dysfunction

• US 7,981,147 B2
• Filed: 01/17/2008
• Issued: 07/19/2011
• Est. Priority Date: 05/15/2006
• Status: Expired due to Fees

• Current Assignee: TearScience Inc. (Johnson & Johnson)
• Original Assignee: TearScience Inc. (Johnson & Johnson)
• Inventors: Gravely, Benjamin Tyson, Grenon, Stephen M., Willis, Timothy R., Korb, Donald R.
• Primary Examiner(s): Gibson; Roy D.
• Assistant Examiner(s): SMITH, KAITLYN ELIZABETH
• Application Number:
  US12/015,576
• Publication Number:
  US 20080132978A1
• Time in Patent Office: 1,279 Days
• Field of Search: 604/289
• US Class Current: 607/96
• CPC Class Codes: A61B 18/12 by passing a current through the tissue to be heated, e.g. high-frequency current
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 2018/046 in liquid form
• CPC Class Codes: A61B 2018/048 in gaseous form
• CPC Class Codes: A61F 2007/0004 Eyes or part of the face surrounding the eyes
• CPC Class Codes: A61F 2007/0059 with an open fluid circuit
• CPC Class Codes: A61F 7/007 characterised by electric heating
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61F 9/00718 Restoration of lid function
• CPC Class Codes: A61H 2015/0014 cylinder-like, i.e. rollers
• CPC Class Codes: A61H 7/00 Devices for suction-kneading massage; Devices for massaging the skin by rubbing or brushing not otherwise provided for electro-medical massage devices applying electric current by contact A61N1/18
• CPC Class Codes: A61K 31/65 Tetracyclines
• CPC Class Codes: A61K 38/1841 Transforming growth factor [TGF]
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

A method of treating meibomian gland dysfunction. Heat is applied to the outside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force may also be applied to the outside of the patient'"'"'s eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions or occlusions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reach desired temperature levels and/or aid in reducing discomfort to the patient during treatment.

Claims

1. A method of treating meibomian gland dysfunction, comprising:

applying heat to an outer surface of a patient'"'"'s eyelid to a temperature level to melt, loosen, or soften an obstruction located within a meibomian gland channel of a meibomian gland;

maintaining the heat to the outer surface of the patient'"'"'s eyelid for a period of time; and

applying a compressive force to the outer surface of the patient'"'"'s eyelid to express the obstruction located within the meibomian gland channel from within the meibomian gland channel through a meibomian gland orifice of the meibomian gland.

2. The method of claim 1, further comprising expressing the obstruction from the meibomian gland channel.

3. The method of claim 2, wherein the expressing is performed during the maintaining the heat for the period of time.

4. The method of claim 2, further comprising removing the heat from the outer surface of the patient'"'"'s eyelid, wherein the expressing is performed after the removing the heat from the outer surface of the patient'"'"'s eyelid.

5. The method of claim 2, further comprising removing the heat from the outer surface of the patient'"'"'s eyelid.

6. The method of claim 1, further comprising repeatedly performing the applying heat and maintaining of the heat after a selected period of time to maintain the obstruction in the melted, loosened, or softened state.

7. The method of claim 1, wherein the period of time for maintaining the heat is from approximately 1 to 10 minutes.

8. The method of claim 1, wherein the temperature level is between approximately 43 and 47 degrees Celsius.

9. The method of claim 1, further comprising treating the patient'"'"'s eyelid or meibomian gland with a pharmacological agent to promote the free flow of fluids from the meibomian gland.

10. The method of claim 9, wherein the pharmacological agent is an agent selected from the group consisting of antibiotics, topical tetracycline, topical corticosteroids, oral corticosteroids, topical androgens, topical androgen analogues, TGF-β

, omega 3 compositions, enzymes that promote lipid productions, agents that stimulate production of enzymes that promote lipid production, agents that act as a secretagogue to enhance meibomian gland secretion, an agent that replaces production of a tear component, and an agent that promotes production of a tear component.

11. The method of claim 1, further comprising maintaining the compressive force to the outer surface of the patient'"'"'s eyelid for a period of time.

12. The method of claim 11, wherein the maintaining the compressive force expresses the obstruction located within the meibomian gland channel from the meibomian gland channel while the obstruction remains in a melted, loosened, or softened state.

13. The method of claim 11, wherein the maintaining the compressive force reduces blood flow in the eyelid to reduce thermal dissipation from the patient'"'"'s eyelid.

14. The method of claim 11, wherein the temperature level is between approximately 43 and 55 degrees Celsius.

15. The method of claim 11, further comprising expressing the obstruction located within the meibomian gland channel from the meibomian gland channel.

16. The method of claim 15, wherein the expressing is performed during the maintaining of the heat for a period of time.

17. The method of claim 15, wherein the expressing is performed during the maintaining of the heat for a period of time and maintaining the compressive force for a period of time.

18. The method of claim 15, further comprising removing the heat from the outer surface of the patient'"'"'s eyelid, wherein the expressing is performed after the removing of the heat from the outer surface of the patient'"'"'s eyelid.

19. The method of claim 11, further comprising removing the compressive force from the outer surface of the patient'"'"'s eyelid, wherein the expressing is performed after the removing the compressive force from the outer surface of the patient'"'"'s eyelid.

20. The method of claim 11, further comprising expressing the obstruction located within the meibomian gland channel from the meibomian gland channel during the maintaining of the compressive force to the outer surface of the patient'"'"'s eyelid.

21. The method of claim 15, further comprising repeatedly performing the applying heat and maintaining of the heat after a selected period of time, and applying and maintaining the compressive force after a selected period of time to express the obstruction located within the meibomian gland channel from the meibomian gland channel while in the melted, loosened, or softened state.

22. The method of claim 11, wherein the period of time for maintaining the compressive force is from approximately 1 to 10 minutes.

23. The method of claim 11, wherein applying heat further comprises positioning an insulator behind the patient'"'"'s eyelid on an outer surface sclera of the eye.

24. The method of claim 1, further comprising regulating the heat when applying the heat to the outer surface of the patient'"'"'s eyelid.

25. The method of claim 1, further comprising regulating the compressive force when applying the compressive force to the outer surface of the patient'"'"'s eyelid.

26. The method of claim 1, wherein the compressive force applied to the outer surface of the patient'"'"'s eyelid is comprised from the group consisting of a mechanical force, an electrical force, a pneumatic force, and a manual compression force.