System and method for analyte measurement

• US 7,981,363 B2
• Filed: 01/08/2008
• Issued: 07/19/2011
• Est. Priority Date: 12/22/1997
• Status: Expired due to Fees

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG), Roche Operations Limited (Roche Holding AG)
• Inventors: Beaty, Terry A., Burke, David W., Svetnik, Vladimir, Kuhn, Lance S.
• Primary Examiner(s): Soderquist; Arlen
• Application Number:
  US11/970,952
• Publication Number:
  US 20080098802A1
• Time in Patent Office: 1,288 Days
• Field of Search: 204/401, 204/403, 204/403.1, 204/400, 204/403.01, 204/403.02, 204/403.14, 205/777.5, 205/792, 422 56- 58, 422 8201- 8203, 436/34, 436/43, 436/46, 436/50, 436/55, 436/95, 436149-151, 436/183
• US Class Current: 422/82.01
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/112499 with sample on test slide
• CPC Class Codes: Y10T 436/115831 Condition or time responsive
• CPC Class Codes: Y10T 436/12 Condition responsive control
• CPC Class Codes: Y10T 436/142222 Hetero-O [e.g., ascorbic acid, etc.]
• CPC Class Codes: Y10T 436/143333 Saccharide [e.g., DNA, etc.]
• CPC Class Codes: Y10T 436/144444 Glucose
• CPC Class Codes: Y10T 436/203332 Hydroxyl containing

Abstract

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

Claims

1. An apparatus for determining the concentration of a medically significant component of a biological fluid, the apparatus comprising:

a cell for receiving a sample of the fluid, the cell supporting;

a chemistry which reacts with the medically significant component; and

first and second terminals across which the reaction of the chemistry with the medically significant component can be assessed;

wherein at least a portion of said chemistry is in contact with said first and second terminals;

an instrument having;

first and second terminals complementary to the first and second terminals, respectively, of the cell;

wherein placement of the first and second terminals of the cell in contact with the first and second terminals, respectively, of the instrument permits the instrument to assess the reaction; and

an assessment controller for;

applying across the first and second terminals of the instrument a first signal;

determining a first correction value in response of the cell to the first signal, wherein the determining a first correction value step comprises;

determining a frequency response of the cell to the first signal;

comparing the frequency response of the cell to a stored frequency response characteristic of a specific interferent to determine an interferent concentration; and

determining the first correction value based upon the interferent concentration;

assessing the reaction of the medically significant component with the chemistry; and

combining the correction value with the result of the reaction assessment to produce an indication of the concentration of the medically significant component of the sample;

wherein the first signal comprises a signal having an AC component.

2. The apparatus of claim 1, wherein:

the biological fluid comprises blood;

the medically significant component comprises glucose; and

said chemistry comprises a chemistry which reacts with the glucose in the blood.

3. The apparatus of claim 2, wherein the first correction value comprises an indicated glucose-to-actual glucose correction factor.

4. The apparatus of claim 1, wherein the first signal comprises an AC signal.

5. The apparatus of claim 1, wherein:

the biological fluid comprises blood;

the medically significant component comprises glucose;

the interferent comprises hematocrit; and

said chemistry comprises a chemistry which reacts with the glucose in the blood.

6. The apparatus of claim 5, wherein the first correction value comprises an indicated glucose-to-actual glucose correction factor.