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Compositions and methods for the therapy and diagnosis of cytomegalovirus

  • US 7,982,012 B2
  • Filed: 03/10/2009
  • Issued: 07/19/2011
  • Est. Priority Date: 03/10/2008
  • Status: Expired due to Fees
First Claim
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1. An isolated anti-CMV antibody, wherein said antibody comprises:

  • (a) a VH region comprising(i) a VH CDR1 region comprising the amino acid sequence of SSNGIH (SEQ ID NO;

         57);

    (ii) a VH CDR2 region comprising the amino acid sequence of VISSDANDKQYADSVKG (SEQ ID NO;

         58); and

    (iii) a VH CDR3 region comprising the amino acid sequence of DGTCSGGNCYSGLIDY (SEQ ID NO;

         59); and

    (b) a VL region comprising(i) a VL CDR1 region comprising the amino acid sequence of RASQSVGGYLA (SEQ ID NO;

         43);

    (ii) a VL CDR2 region comprising the amino acid sequence of ASIRAT (SEQ ID NO;

         64); and

    (iii) a VL CDR3 region comprising the amino acid sequence of HQRSNWPPLT (SEQ ID NO;

         65).

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