Compositions and methods for the therapy and diagnosis of cytomegalovirus
First Claim
Patent Images
1. An isolated anti-CMV antibody, wherein said antibody comprises:
- (a) a VH region comprising(i) a VH CDR1 region comprising the amino acid sequence of SSNGIH (SEQ ID NO;
57);
(ii) a VH CDR2 region comprising the amino acid sequence of VISSDANDKQYADSVKG (SEQ ID NO;
58); and
(iii) a VH CDR3 region comprising the amino acid sequence of DGTCSGGNCYSGLIDY (SEQ ID NO;
59); and
(b) a VL region comprising(i) a VL CDR1 region comprising the amino acid sequence of RASQSVGGYLA (SEQ ID NO;
43);
(ii) a VL CDR2 region comprising the amino acid sequence of ASIRAT (SEQ ID NO;
64); and
(iii) a VL CDR3 region comprising the amino acid sequence of HQRSNWPPLT (SEQ ID NO;
65).
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Abstract
The present invention provides novel anti-cytomegalovirus antibodies and related compositions and methods. These antibodies may be used in the diagnosis, prevention, and treatment of cytomegalovirus infection.
64 Citations
11 Claims
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1. An isolated anti-CMV antibody, wherein said antibody comprises:
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(a) a VH region comprising (i) a VH CDR1 region comprising the amino acid sequence of SSNGIH (SEQ ID NO;
57);(ii) a VH CDR2 region comprising the amino acid sequence of VISSDANDKQYADSVKG (SEQ ID NO;
58); and(iii) a VH CDR3 region comprising the amino acid sequence of DGTCSGGNCYSGLIDY (SEQ ID NO;
59); and(b) a VL region comprising (i) a VL CDR1 region comprising the amino acid sequence of RASQSVGGYLA (SEQ ID NO;
43);(ii) a VL CDR2 region comprising the amino acid sequence of ASIRAT (SEQ ID NO;
64); and(iii) a VL CDR3 region comprising the amino acid sequence of HQRSNWPPLT (SEQ ID NO;
65). - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11)
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2. An isolated anti-CMV antibody, wherein said antibody comprises:
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(a) a VH region comprising (i) a VH CDR1 region comprising the amino acid sequence of GFTFSS (SEQ ID NO;
60);(ii) a VH CDR2 region comprising the amino acid sequence of VISSDANDKQ (SEQ ID NO;
61); and(iii) a VH CDR3 region comprising the amino acid sequence of DGTCSGGNCYSGLIDY (SEQ ID NO;
59); and(b) a VL region comprising (i) a VL CDR1 region comprising the amino acid sequence of RASQSVGGYLA (SEQ ID NO;
43);(ii) a VL CDR2 region comprising the amino acid sequence of ASIRAT (SEQ ID NO;
64); and(iii) a VL CDR3 region comprising the amino acid sequence of HQRSNWPPLT (SEQ ID NO;
65).
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3. An isolated anti-CMV antibody comprising:
a heavy chain sequence comprising the amino acid sequence of SEQ ID NO;
56 and a light chain sequence comprising amino acid sequence SEQ ID NO;
63.
Specification