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Lipid encapsulated interfering RNA

  • US 7,982,027 B2
  • Filed: 06/27/2006
  • Issued: 07/19/2011
  • Est. Priority Date: 07/16/2003
  • Status: Active Grant
First Claim
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1. A nucleic acid-lipid particle, said nucleic acid-lipid particle comprising:

  • a chemically synthesized siRNA;

    a cationic lipid;

    a non-cationic lipid; and

    a conjugated lipid that inhibits aggregation of particles, wherein the conjugated lipid that inhibits aggregation of particles comprises a polyethyleneglycol-dialkyloxypropyl (PEG-DAA) conjugate having the following structure;

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