Measuring conduction velocity using one or more satellite devices
First Claim
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1. A method of determining conduction velocity of a depolarization wave in a tissue, the method comprising:
- (a) providing a first satellite coupled to a central controller, the first satellite having a first satellite circuit and at least two individually and separately addressable first satellite electrodes, the first satellite circuit adapted to simultaneously and separately couple and decouple each of the at least two first satellite electrodes as directed by the central controller;
(b) providing a second satellite coupled to the central controller, the second satellite having a second satellite circuit and at least two individually and separately addressable second satellite electrodes, the second satellite circuit adapted to simultaneously and separately couple and decouple each of the at least two second satellite electrodes as directed by the central controller;
(c) determining a time interval between a first satellite'"'"'s reporting of a depolarization wave in the tissue and a second satellite'"'"'s reporting of a depolarization wave in the tissue, wherein the first satellite and the second satellite are formed on a lead, and wherein the second satellite is located a fixed distance away from the first satellite; and
(d) calculating the conduction velocity using the time interval and the fixed distance between the first satellite and the second satellite.
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Abstract
A method for measuring the conduction velocity of a depolarization wave in a tissue employs a first satellite located within the tissue and a second that satellite is located within the tissue a distance away from the first satellite, e.g., by using the time of depolarization wave as reported from each satellite and the distance to determine velocity of the wave. Also provided are systems and kits that find use in accordance with the invention.
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Citations
43 Claims
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1. A method of determining conduction velocity of a depolarization wave in a tissue, the method comprising:
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(a) providing a first satellite coupled to a central controller, the first satellite having a first satellite circuit and at least two individually and separately addressable first satellite electrodes, the first satellite circuit adapted to simultaneously and separately couple and decouple each of the at least two first satellite electrodes as directed by the central controller; (b) providing a second satellite coupled to the central controller, the second satellite having a second satellite circuit and at least two individually and separately addressable second satellite electrodes, the second satellite circuit adapted to simultaneously and separately couple and decouple each of the at least two second satellite electrodes as directed by the central controller; (c) determining a time interval between a first satellite'"'"'s reporting of a depolarization wave in the tissue and a second satellite'"'"'s reporting of a depolarization wave in the tissue, wherein the first satellite and the second satellite are formed on a lead, and wherein the second satellite is located a fixed distance away from the first satellite; and (d) calculating the conduction velocity using the time interval and the fixed distance between the first satellite and the second satellite. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method of stimulating cardiac tissue, the method comprising:
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locating a first satellite coupled to a central controller relative to the tissue, the first satellite having a first satellite circuit and at least two first satellite electrodes, the first satellite circuit adapted to individually reconfigurably couple and decouple each of the at least two first satellite electrodes as directed by the central controller; locating a second satellite coupled to the central controller relative to the tissue, the second satellite having a second satellite circuit and at least two second satellite electrodes, the second satellite circuit adapted to individually reconfigurably couple and decouple each of the at least two second satellite electrodes as directed by the central controller; determining a time interval between a first satellite'"'"'s reporting of a depolarization wave in the tissue and a second satellite'"'"'s reporting of a depolarization wave in the tissue, wherein the first satellite and the second satellite are formed on a lead, and wherein the second satellite is located a fixed distance away from the first satellite; calculating a conduction velocity using the time interval and the fixed distance between the first satellite and the second satellite; identifying a region of abnormal depolarization wavefront conduction in the tissue using at least the conduction velocity; and applying a stimulus to the tissue in a manner sufficient to compensate for the region of abnormal depolarization wave conduction. - View Dependent Claims (33, 34, 35)
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36. A system for determining conduction velocity of a depolarization wave in a tissue, the system comprising:
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(a) locating a first satellite coupled to a central controller relative to the tissue, the first satellite having a first satellite circuit and at least two first satellite electrodes, the first satellite circuit adapted to individually reconfigurably couple and decouple each of the at least two first satellite electrodes as directed by the central controller; (b) locating a second satellite coupled to the central controller relative to the tissue, the second satellite having a second satellite circuit and at least two second satellite electrodes, the second satellite circuit adapted to individually reconfigurably couple and decouple each of the at least two second satellite electrodes as directed by the central controller; (c) the first satellite and the second satellite positioned a fixed distance away from the first satellite, wherein each of the first and second satellite is configured to report a depolarization wave in the tissue; and (d) a signal processing element configured to; (i) determine a time interval between the first satellite'"'"'s reporting of a depolarization wave in the tissue and the second satellite'"'"'s reporting of the depolarization wave in the tissue; and (ii) calculate a conduction velocity of the depolarization wave in the tissue using the time interval and the fixed distance between the first satellite and the second satellite. - View Dependent Claims (37, 38, 39, 40, 41, 42)
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43. A non-transitory computer readable storage medium having a processing program stored thereon, wherein the processing program, when executed by a processor, is configured to perform a method comprising:
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directing a first satellite having at least two first satellite electrodes to individually reconfigurably couple and decouple each of at least two first satellite electrodes as directed by a central controller; directing a second satellite having at least two second satellite electrodes to individually reconfigurably couple and decouple each of at least two second satellite electrodes as directed by the central controller; determining a time interval between a first satellite'"'"'s reporting of a depolarization wave in a tissue and a second satellite'"'"'s reporting of a depolarization wave in the tissue, wherein the first satellite and the second satellite are formed on a lead, and wherein the second satellite is located a fixed distance away from the first satellite; and calculating a conduction velocity using the time interval and the fixed distance between the first satellite and the second satellite.
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Specification