Gastric electrical stimulation with multi-site stimulation anti-desensitization feature

• US 7,983,755 B2
• Filed: 09/24/2008
• Issued: 07/19/2011
• Est. Priority Date: 10/01/2007
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Starkebaum, Warren L., Maude-Griffin, Roland C., Yuan, Charlene X., Pivotto, Luiz Geraldo
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US12/236,924
• Publication Number:
  US 20090088819A1
• Time in Patent Office: 1,028 Days
• Field of Search: 607/40, 607/133
• US Class Current: 607/40
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

The disclosure is directed to gastric stimulation programmers, stimulators and methods for controlling delivery of gastric stimulation therapy to maintain the efficacy of the therapy over time. Maintaining the efficacy of gastric stimulation therapy may be possible by implementing one or more anti-desensitization features in a gastric stimulation controller or stimulator. As electrical stimulation therapy is continuously delivered to a patient, the stimulated tissue may become desensitized to the electrical stimulation therapy such that the beneficial effect of the electrical stimulation is diminished. Once desensitization occurs, the affected tissue may not respond favorably to electrical stimulation therapy. Application of one or more anti-desensitization features to control gastric stimulation therapy may reduce or prevent desensitization and effectively extend the efficacy of the therapy over time.

Claims

1. A method for gastric stimulation with reduced desensitization, the method comprising:

delivering first electrical stimulation therapy to a gastrointestinal organ of a patient via a first electrode combination positioned at a first position on the gastrointestinal organ for a first period of time greater than or equal to approximately 30 seconds; and

delivering second electrical stimulation therapy to the gastrointestinal organ via a second electrode combination positioned at a second position on the gastrointestinal organ for a second period of time greater than or equal to approximately 30 seconds,

wherein the first and second electrical stimulation therapies are configured to produce a substantially identical therapeutic result, and wherein at least one electrode of the first electrode combination is displaced at least approximately three centimeters from at least one electrode of the second electrode combination.

2. The method of claim 1, wherein each of the first and second periods of time is greater than or equal to approximately one minute.

3. The method of claim 1, wherein each of the first and second periods of time is greater than or equal to approximately five minutes.

4. The method of claim 1, wherein the first and second periods of time do not overlap.

5. The method of claim 1, wherein the first and second periods of time partially overlap.

6. The method of claim 1, further comprising delivering the first and second electrical stimulation therapy on one of a time-alternating basis to provide a combined stimulation therapy delivery that produces the therapeutic result, or a time-independent basis to provide separate stimulation therapy deliveries that produce the therapeutic result.

7. The method of claim 1, wherein the gastrointestinal organ includes one of a stomach or a small intestine of the patient, and the stimulation parameters associated with the first and second electrical stimulation therapy are substantially identical.

8. The method of claim 1, further comprising:

delivering third electrical stimulation therapy to the gastrointestinal organ via a third electrode combination positioned at a third position on the gastrointestinal organ at a third time,

repeating the delivery of the first, second and third electrical stimulation therapies for the first, second and third periods of time; and

selecting an order of the first, second and third periods of time in a varying order for at least some of the repeated deliveries,

wherein the first, second and third electrical stimulation therapies are configured to produce a substantially identical therapeutic result, and

wherein the first, second and third positions are arranged such that the first position is most proximal on the gastrointestinal organ, the third position is most distal on the gastrointestinal organ, and the second position is between the first and third positions.

9. The method of claim 1, wherein the substantially identical therapeutic effect includes promotion of gastric distention or discomfort to discourage food intake by the patient.

10. The method of claim 1, wherein the at least one electrode of the first electrode combination is displaced at least approximately five centimeters from the at least one electrode of the second electrode combination.

11. The method of claim 1, wherein the at least one electrode of the first electrode combination is one of a first set of electrodes coupled to a first lead, the at least one electrode of the second electrode combination is one of a second set of electrodes coupled to a second lead, and the first set of electrodes is displaced from the second set of electrodes by at least approximately three centimeters.

12. The method of claim 1, wherein the at least one electrode of the first electrode combination is coupled to a first lead of a gastrointestinal electrical stimulation device, and the at least one electrode of the second electrode combination is coupled to a second lead of the gastrointestinal electrical stimulation device.

13. A gastrointestinal electrical stimulation device comprising:

a first electrode combination implantable at a first position on a gastrointestinal organ of a patient;

a second electrode combination implantable at a second position on the gastrointestinal organ; and

a stimulation generator that delivers first electrical stimulation therapy to the gastrointestinal organ via the first electrode combination for a first period of time greater than or equal to approximately 30 seconds, and delivers second electrical stimulation therapy to the gastrointestinal organ via a second electrode combination for a second period of time greater than or equal to approximately 30 seconds,

wherein the first and second electrical stimulation therapies are configured to produce a substantially identical therapeutic result, at least one electrode of the first electrode combination is configured to be displaced upon implantation at least approximately three centimeters from at least one electrode of the second electrode combination, the at least one electrode of the first electrode combination is coupled to a first lead of the gastrointestinal electrical stimulation device, and the at least one electrode of the second electrode combination is coupled to a second lead of the gastrointestinal electrical stimulation device.

14. The device of claim 13, wherein each of the first and second periods of time is greater than or equal to approximately one minute.

15. The device of claim 13, wherein each of the first and second periods of time is greater than or equal to approximately five minutes.

16. The device of claim 13, wherein the first and second periods of time do not overlap.

17. The device of claim 13, wherein the first and second periods of time partially overlap.

18. The device of claim 13, wherein the stimulation generator delivers the first and second electrical stimulation therapy on one of a time-alternating basis to provide a combined stimulation therapy delivery that produces the therapeutic result, or a time-independent basis to provide separate stimulation therapy deliveries that produce the therapeutic result.

19. The device of claim 13, wherein the gastrointestinal organ includes one of a stomach or a small intestine of the patient, and the stimulation parameters associated with the first and second electrical stimulation therapy are substantially identical.

20. The device of claim 13, wherein the stimulation generator delivers third electrical stimulation therapy to the gastrointestinal organ via a third electrode combination positioned at a third position on the gastrointestinal organ at a third time, repeats the delivery of the first, second and third electrical stimulation therapies for the first, second and third periods of time, and selects an order of the first, second and third periods of time in a varying order for at least some of the repeated deliveries, wherein the first, second and third electrical stimulation therapies are configured to produce a substantially identical therapeutic result.

21. The device of claim 13, wherein the substantially identical therapeutic effect includes promotion of gastric distention or discomfort to discourage food intake by the patient.

22. The device of claim 13, wherein the at least one electrode of the first electrode combination is configured to be displaced at least approximately five centimeters from the at least one electrode of the second electrode combination upon implantation.

23. The device of claim 13, wherein the at least one electrode of the first electrode combination is one of a first set of electrodes coupled to the first lead, the at least one electrode of the second electrode combination is one of a second set of electrodes coupled to the second lead, and the first set of electrodes is configured to be displaced from the second set of electrodes by at least approximately three centimeters upon implantation.

24. A gastrointestinal electrical stimulation device comprising:

means for delivering first electrical stimulation therapy to a gastrointestinal organ of a patient via a first electrode combination positioned at a first position on the gastrointestinal organ for a first period of time greater than or equal to approximately 30 seconds; and

means for delivering second electrical stimulation therapy to the gastrointestinal organ via a second electrode combination positioned at a second position on the gastrointestinal organ for a second period of time greater than or equal to approximately 30 seconds,

wherein the first and second electrical stimulation therapies are configured to produce a substantially identical therapeutic result, at least one electrode of the first electrode combination is configured to be displaced upon implantation at least approximately three centimeters from at least one electrode of the second electrode combination, the at least one electrode of the first electrode combination is coupled to a first lead of the gastrointestinal electrical stimulation device and the at least one electrode of the second electrode combination is coupled to a second lead of the gastrointestinal electrical stimulation device.

25. The device of claim 24, wherein each of the first and second periods of time is greater than or equal to approximately one minute.

26. The device of claim 24, wherein each of the first and second periods of time is greater than or equal to approximately five minutes.

27. The device of claim 24, wherein the first and second periods of time do not overlap.

28. The device of claim 24, wherein the first and second periods of time partially overlap.

29. The device of claim 24, further comprising means for delivering the first and second electrical stimulation therapy on one of a time-alternating basis to provide a combined stimulation therapy delivery that produces the therapeutic result, or a time-independent basis to provide separate stimulation therapy deliveries that produce the therapeutic result.

30. The device of claim 24, wherein the gastrointestinal organ includes one of a stomach or a small intestine of the patient, and the stimulation parameters associated with the first and second electrical stimulation therapy are substantially identical.

31. The device of claim 24, further comprising:

means for delivering third electrical stimulation therapy to the gastrointestinal organ via a third electrode combination positioned at a third position on the gastrointestinal organ at a third time,

means for repeating the delivery of the first, second and third electrical stimulation therapies for the first, second and third periods of time; and

means for selecting an order of the first, second and third periods of time in a varying order for at least some of the repeated deliveries,

wherein the first, second and third electrical stimulation therapies are configured to produce a substantially identical therapeutic result.

32. The device of claim 24, wherein the substantially identical therapeutic effect includes promotion of gastric distention or discomfort to discourage food intake by the patient.

33. The device of claim 24, wherein the at least one electrode of the first electrode combination is configured to be displaced at least approximately live centimeters from the at least one electrode of the second electrode combination upon implantation.

34. The device of claim 24, wherein the at least one electrode of the first electrode combination is one of a first set of electrodes coupled to the first lead, the at least one electrode of the second electrode combination is one of a second set of electrodes coupled to the second lead, and the first set of electrodes is configured to be displaced from the second set of electrodes by at least approximately three centimeters upon implantation.