Heart monitoring apparatus

• US 7,985,185 B2
• Filed: 06/03/2008
• Issued: 07/26/2011
• Est. Priority Date: 06/03/2008
• Status: Expired due to Fees

• Current Assignee: Biotronik SE & Company KG
• Original Assignee: Biotronik CRM Patent AG (Biotronik SE & Company KG)
• Inventors: De Voir, Christopher S., Orlov, Michael V., Muessig, Dirk, Lefkov, Sharon
• Primary Examiner(s): Patel; Niketa I
• Assistant Examiner(s): Lavert; Nicole F
• Application Number:
  US12/132,477
• Publication Number:
  US 20090299203A1
• Time in Patent Office: 1,148 Days
• Field of Search: 600/374, 600/483, 600506-509
• US Class Current: 600/508
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

Heart monitoring apparatus with sensing stage connectable to intracardiac electrode picking up electric potentials and adapted to process electric signals representing a time course of said potentials, a mechanical action detection stage adapted to generate a geometry signal having a time course reflecting heart chamber'"'"'s geometry change, an evaluation unit connected to sensing stage and impedance measuring stage and adapted to determine a first and second fiducial point in the time course of said potentials and geometry signal, respectively, both fiducial points belonging to same heart cycle, and to determine a measured time delay between said fiducial points. Evaluation unit adapted to repeat said determined time delay to determine plurality of measured time delays and variance thereof or divergence of the statistical properties of cycle times based on said time course of said electric potentials versus cycle times based on said time course reflecting a change of a heart chamber'"'"'s geometry.

Claims

1. An implantable heart monitoring apparatus, comprising:

at least one intracardiac electrode configured to pick up electric potentials of a myocardium of a heart'"'"'s ventricle or atrium;

at least one sensing stage connected to said at least one intracardiac electrode, wherein said at least one sensing stage is configured to process electric signals that represent a time course of said electric potentials;

at least one mechanical action detection stage configured to generate a geometry signal that reflects mechanical action of a heart chamber, said geometry signal having a time course that reflects a change of a heart chamber'"'"'s geometry wherein said at least one mechanical action detection stage comprises an impedance measuring stage within said implantable heart monitoring apparatus that is connected to said at least one intracardiac electrode and configured to determine a time course of an intracardiac impedance or conductance signal that reflects an intracardiac impedance or conductance detected with said at least one intracardiac electrode, wherein said intracardiac impedance or conductance signal is utilized as said geometry signal;

an evaluation unit coupled with said at least one sensing stage and to said at least one mechanical action detection stage, said evaluation unit configured to determine

a first fiducial point in the time course of said electric potentials and

a second fiducial point in the time course of said geometry signal,

wherein said first fiducial point and said second fiducial point belong to a same heart cycle, and wherein said evaluation unit is further configured to determine

a measured time delay between said first and said second fiducial points that represent a difference in time between corresponding points in said time course of said electric potentials versus said time course of said geometry signal respectively;

said evaluation unit further configured to repeat said determination of said measured time delay between two fiducial points to thus determine a plurality of measured time delays

and to determine

a variance of said plurality of measured time delays based on said time course of said electric potentials versus said time course of said geometry signal,

or

a divergence of statistical properties of cycle times that are based on said time course of said electric potentials versus cycle times that are based on said time course that reflect said change of said heart chamber'"'"'s geometry; and

,

generate an output signal that indicates a state of heart failure based on said time course of said electric potentials versus said time course of said geometry signal.

2. The implantable heart monitoring apparatus according to claim 1, wherein the evaluation unit is configured to determine a peak in said time course of the intracardiac impedance or a minimum in the time course of the intracardiac conductance as a second fiducial point related to said impedance or conductance, respectively.

3. The implantable heart monitoring apparatus according to claim 1, wherein said at least one sensing stage is configured to detect cardiac events that represent a depolarization of the myocardium wherein said at least one sensing stages is configured to process said electric signals that represent said time course of said electric potentials, wherein said a cardiac event selected from said cardiac events marks a first fiducial point in said time course of said electric potentials.

4. The implantable heart monitoring apparatus according to claim 1, wherein the evaluation unit is configured to determine the divergence of the statistical properties of IEGM and impedance based cycle times and generate an output signal that indicates said state of said heart failure, when the divergence exceeds a predetermined threshold value.

5. The implantable heart monitoring apparatus according to claim 1, wherein the evaluation unit is configured to separate cardiac (Z_cardiac) and respiratory (Z_resp) source signals in the intracardiac impedance signal from each other.

6. The implantable heart monitoring apparatus according to claim 1, wherein the evaluation unit is configured to:

measure a beat to beat interval measurement of the time course of said electric potentials at sufficient time resolution to reveal a heart rate variance;

identify a fiducial point, comprising threshold crossing of the time course of said electric potentials;

calculate statistics of the threshold crossings in the measurement;

concurrently, sample the intra cardiac impedance separating cardiac (Z_cardiac) and respiratory (Z_resp) source signals from each other;

identify in Z_cardiac a fiducial point, comprising each peak of a systolic artifact resulting from each threshold crossing of the time course of said electric potentials; and

,

calculate a measured time delay between each threshold crossing of an electrogram to each Z_cardiac peak.

7. The implantable heart monitoring apparatus according to claim 6, wherein the evaluation unit is further configured to:

calculate statistics of threshold crossings to Z_cardiac peak delay (linkage) using a dispersion measure wherein said dispersion measure comprises interquartile range or SD50; and

,

calculate a Z_cardiac peak beat to beat interval such that it is the sum of the beat to beat interval and the Z_cardiac peak delay for each beat and constitutes a mechanical analog to said measurement.

8. The implantable heart monitoring apparatus according to claim 1, wherein said time course of said electric potentials is a right ventricular intracardiac electrocardiogram and wherein said time course that reflects a change of a heart chamber'"'"'s geometry is a right ventricular intracardiac impedance.

9. The heart monitoring apparatus according to claim 1, wherein said time course of said electric potentials is a right ventricular intracardiac electrocardiogram and wherein said time course that reflects a change of a heart chamber'"'"'s geometry is a left ventricular intracardiac impedance.

10. A method for monitoring a heart'"'"'s health state comprising:

acquiring a signal that represents a time course of electric potentials with at least one intracardiac electrode configured to pick up electric potentials of a myocardium of a heart'"'"'s ventricle or atrium;

acquiring a geometry signal having a time course that reflects a change of a heart chamber'"'"'s geometry using said at least one intracardiac electrode coupled with a impedance measuring stage within an implantable heart apparatus;

determining a first fiducial point in the time course of said electric potentials;

determining a second fiducial point in the time course of said geometry signal, said first fiducial point and said second fiducial point belonging to the same heart cycle;

determining a measured time delay between said first and said second fiducial point that represent a difference in time between corresponding points in said time course of said electric potentials versus said time course of said geometry signal respectively;

repeating said determining said measured time delay between two fiducial points to thus determine a plurality of measured time delays; and

determining

a variance of said plurality of measured time delays based on said time course of said electric potentials versus said time course of said geometry signal,

or

a divergence of statistical properties of cycle times that are based on said time course of said electric potentials versus cycle times that are based on said time course that reflect said change of said heart chamber'"'"'s geometry; and

generating an output signal that indicates a state of heart failure based on said time course of said electric potentials versus said time course of said geometry signal.

11. The method for monitoring a heart'"'"'s health state according to claim 10 further comprising:

measuring a beat to beat interval of the time course of said electric potentials at sufficient time resolution to reveal a heart rate variance;

identifying a fiducial point, comprising a threshold crossing of the time course of said electric potentials;

calculating statistics of threshold crossings in the measurement;

concurrently, sampling intracardiac impedance values that represent said time course of said geometry signal and separating cardiac (Z_cardiac) and respiratory (Z_resp) source signals from each other;

identifying in Z_cardiac a fiducial point, that includes each peak of a systolic artifact resulting from each threshold crossing of the time course of said electric potentials; and

,

calculating the measured time delay between each threshold crossing of an electrogram to each Z_cardiac peak.

12. The method for monitoring a heart'"'"'s health state according to claim 10 further comprising:

separating cardiac (Z_cardiac) and respiratory (Z_resp) source signals in the intracardiac impedance signal from each other.

13. The method for monitoring a heart'"'"'s health state according to claim 10 further comprising:

calculating statistics of threshold crossings to Z_cardiac peak delay (linkage) using a dispersion measure wherein said dispersion measure comprises interquartile range or SD50; and

,

calculating a Z_cardiac peak beat to beat interval such that it is the sum of the beat to beat interval and the Z_cardiac peak delay for each beat and constitutes a mechanical analog to said measurement.