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Device and process for metering solutions

  • US 7,985,198 B2
  • Filed: 06/16/2006
  • Issued: 07/26/2011
  • Est. Priority Date: 09/23/2005
  • Status: Expired due to Fees
First Claim
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1. A process for metering liquids from a plurality of fluid sources, in a time-multiplex manner according to a fluid release plan, into a common patient line, the process comprising the steps of:

  • providing a common patient line having a cross-sectional area in a range between 0.002 mm2 and 0.2 mm2, which corresponds to a diameter between 0.05 mm and 0.5 mm in case of a circular cross section;

    providing a carrier liquid reservoir with a carrier liquid, the common patient line having carrier liquid therein and being in fluid connection with the carrier liquid reservoir;

    connecting each of the plurality of fluid sources to the common patient line by a respective metering passage;

    selecting at least two fluid sources according to a fluid release plan;

    removing fluid volumes in the range of 50 nL to 50 μ

    L from each of the selected fluid sources;

    forming a fluid stream from a sequence of the fluid volumes of at least two different said fluid sources in the common patient line, wherein fluid volumes of immiscible solutions are separated by a separation medium to provide discrete boluses of the fluid volumes flowing out of the common patient line to a patient with the fluid volumes remaining separated by the separation medium and in a particular order as they flow through the common patient line to the patient;

    adding up of the individual metered fluid volumes for each source to determine a total volume; and

    comparing the total volumes administered for each solution with the fluid release plan in order to minimize deviations.

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