Bioerodible endoprosthesis

• US 7,985,252 B2
• Filed: 07/30/2008
• Issued: 07/26/2011
• Est. Priority Date: 07/30/2008
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Chandrasekaran, Chandru, Schewe, Scott R., Merdan, Ken, Radhakrishnan, Rajesh
• Primary Examiner(s): Isabella; David
• Assistant Examiner(s): Swaminathan; Seema
• Application Number:
  US12/182,768
• Publication Number:
  US 20100030326A1
• Time in Patent Office: 1,091 Days
• Field of Search: 623/1.11, 623/1.13, 623/1.15, 623/1.39, 623/1.42, 623/1.44, 623/1.45, 623/1.46, 623/1.38
• US Class Current: 623/1.46
• CPC Class Codes: A61L 31/08 Materials for coatings

Abstract

An endoprosthesis includes a plurality of struts defining a flow passage. At least one strut includes (a) a body comprising a bioerodible material and having a thickness and (b) a coating overlying the body. The coating includes a plurality of regions that allow physiological fluids to contact a plurality of corresponding areas of the underlying body when the endoprosthesis is implanted in a physiological environment. The plurality of regions are sized and arranged so that the contacted areas of the body erode substantially through the body in the thickness direction while the coating remains on the body when the endoprosthesis is implanted in the physiological environment.

Claims

1. An endoprosthesis comprising a plurality of struts defining a flow passage, at least one strut comprising:

(a) a body comprising a bioerodible material having a thickness, and

(b) a coating overlying the body, the coating comprising a plurality of regions that allow physiological fluids to contact a plurality of corresponding areas of the underlying body when the endoprosthesis is implanted in a physiological environment, the plurality of regions being sized and arranged so that the contacted areas of the body erode substantially through the body in the thickness direction while the coating remains on the body when the endoprosthesis is implanted in the physiological environment, wherein a rate of erosion of the body in the thickness direction multiplied by the thickness of the body is less than a rate of erosion of the body along an interface between the body and the coating multiplied by the distance between adjacent regions thereby producing undercut regions.

2. The endoprosthesis of claim 1, wherein the bioerodible material erodes isotropically.

3. The endoprosthesis of claim 2, wherein the plurality of regions are arranged such that the distance between adjacent regions is equal to at least the thickness of the body.

4. The endoprosthesis of claim 2, wherein the plurality of regions are arranged such that the distance between adjacent regions is equal to at least twice the thickness of the body.

5. The endoprosthesis of claim 1, wherein the bioerodible material erodes anisotropically.

6. The endoprosthesis of claim 1, wherein a rate of erosion of the body in the thickness direction multiplied by the thickness of the body is less than a rate of erosion of the body along an interface between the body and the coating multiplied by ½

of the distance between adjacent regions.

7. The endoprosthesis of claim 1, wherein the bioerodible material has a first electric potential and the coating has a second electric potential different from the first electric potential so that the body and the coating form a galvanic couple when the endoprosthesis is implanted in a physiological environment.

8. The endoprosthesis of claim 7, wherein the first electric potential is less than the second electrode potential so that the body acts as an anode and the coating acts as a cathode when the endoprosthesis is implanted in a physiological environment.

9. The endoprosthesis of claim 7, wherein the bioerodible material of the body is a bioerodible metal selected from the group consisting of magnesium, iron, zinc, and alloys thereof and the coating comprises a metal selected from the group consisting of platinum, iridium, and alloys thereof.

10. The endoprosthesis of claim 7, wherein the first electric potential is greater than the second electrode potential so that the body acts as a cathode and the coating acts as an anode when the endoprosthesis is implanted in a physiological environment.

11. The endoprosthesis of claim 1, wherein the bioerodible material of the body is a bioerodible metal selected from the group consisting of magnesium, iron, zinc, and alloys thereof.

12. The endoprosthesis of claim 1, wherein the body comprises a bioerodible polymer selected from the group consisting of polyglutamic acid, poly(ethylene oxide), polycaprolactam, poly(lactic-co-glycolic acid), polysaccharides, and combinations thereof.

13. The endoprosthesis of claim 1, wherein the coating surrounds the circumference of the body.

14. The endoprosthesis of claim 1, wherein the coating partially surrounds the circumference of the body.

15. The endoprosthesis of claim 1, wherein the regions comprise voids in the coating.

16. The endoprosthesis of claim 1, wherein the regions comprise pores in the coating.

17. The endoprosthesis of claim 1, wherein the regions have a higher erosion rate than the remainder of the coating in a physiological environment.

18. The endoprosthesis of claim 1, wherein the coating comprises a bioerodible material having a slower erosion rate than the bioerodible material of the body.

19. The endoprosthesis of claim 1, wherein the endoprosthesis is a stent.