Pharmaceutical composition for preventing and treating diabetes or glucose control abnormality comprising ginsenosides

• US 7,985,848 B2
• Filed: 03/17/2006
• Issued: 07/26/2011
• Est. Priority Date: 03/18/2005
• Status: Expired due to Fees

• Current Assignee: Unigen Corporation
• Original Assignee: Unigen Corporation
• Inventors: Lee, Young-Chul, Kim, Jong-Han, Cha, Ji-Min, Kim, Dong-Seon, Kim, Tae-Woo, Woo, Sung-Sick, Do, Seon-Gil, Oh, Mi-Sun
• Primary Examiner(s): OLSON, ERIC
• Application Number:
  US11/908,947
• Publication Number:
  US 20080234207A1
• Time in Patent Office: 1,957 Days
• Field of Search: None
• US Class Current: 536/5
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 36/258 Panax (ginseng)
• CPC Class Codes: A61P 3/08 for glucose homeostasis pancreatic hormones A61P5/48
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention relates to a composition for preventing or treating diabetes or blood glucose control abnormality comprising gisenosides Rg3, Rg5, and Rk1 from natural substances; a use of a mixture comprising gisenosides Rg3, Rg5, and Rk1 for the manufacture of a medicament for preventing or treating diabetes or blood glucose control abnormality; or a method for preventing or treating diabetes or blood glucose control abnormality by administering a therapeutically effective amount of mixture comprising gisenosides Rg3, Rg5, and Rk1 to a subject. The present composition can effectively prevent or treat diabetes, blood glucose control abnormality, and complication thereof.

Claims

1. A process for preparing a composition for treating diabetes or lowering blood glucose levels comprising gisenosides Rg3, Rg5, and Rk1 comprising the steps of:

(i) treating ginseng with 50% to 100% concentrated acid at 50-80°

C.;

(ii) steaming the treated ginseng at a temperature of from 50°

C. to 110°

C. for 0.5 to 15 hours; and

(iii) extracting the processed ginseng.

2. The process for preparing a composition for treating diabetes or lowering blood glucose levels according to claim 1 wherein the temperature of the steaming is from 50°

C. to lower than 110°

C.

3. The process for preparing a composition for treating diabetes or lowering blood glucose levels according to claim 1 wherein the processed ginseng is extracted with a solvent selected from the group consisting of water, a C_1-4 alcohol, mixing solvent or a mixture thereof.

4. A method for lowering blood glucose levels comprising administering a therapeutically effective amount of a composition prepared by the process of claim 1 to a subject.

5. A method for treating diabetes by administering a therapeutically effective amount of a composition prepared by the process of claim 1 to a subject.