Needle-free injection device

• US 7,988,660 B2
• Filed: 12/19/2006
• Issued: 08/02/2011
• Est. Priority Date: 12/20/2005
• Status: Expired due to Fees

• Current Assignee: Antares Pharma Incorporated, Eli Lilly and Company
• Original Assignee: Eli Lilly and Company
• Inventors: Collins, James Matthew, Fisher, Mark James, O'Fallon, John Michael, Mojarrad, Mehran, Tappel, James G., Byland, Timothy D., Grimley, John, Sampson, Craig Field
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): PATEL, PRITESH ASHOK
• Application Number:
  US12/091,176
• Publication Number:
  US 20080319383A1
• Time in Patent Office: 1,687 Days
• Field of Search: None
• US Class Current: 604/70
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/31518 designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
• CPC Class Codes: A61M 2205/14 Detection of the presence or absence of a tube, a connector or a container in an apparatus
• CPC Class Codes: A61M 2205/332 Force measuring means
• CPC Class Codes: A61M 2205/3341 stabilising pressure or flow to avoid excessive variation
• CPC Class Codes: A61M 2205/3386 Low level detectors
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 5/1782 Devices aiding filling of syringes in situ combination of a vial and a syringe for transferring or mixing their contents A61J1/2096, filling of medical containers in general B65B3/003
• CPC Class Codes: A61M 5/204 connected to external reservoirs for multiple refilling
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member

Abstract

A fluid injecting device (30) generally including a fluid delivery assembly (32) and a needle-free injecting assembly (34). The fluid delivery assembly (32) delivers or transfers the fluid medicine from a cartridge (40) into the needle-free injecting assembly (34) for injecting into a patient. A drive train (112) applies a force to a piston (64) inside the cartridge (40) during the delivery of the fluid to the needle-free injecting assembly (34) to prevent adhesion or static friction between the piston (64) and the cartridge (40). In addition, sensors can be used to help ensure the proper amount of dosage is transferred to the needle-free injecting assembly, conserve power, reduce leakage during disassembly, among other functions.

Claims

1. A device for injecting a fluid dose into a body of a patient comprising:

a needle-free injecting assembly constructed and arranged to deliver the fluid dose into the body, the needle-free injecting assembly including;

a needle-free syringe defining an injection chamber configured to receive the fluid dose, and an outlet; and

a plunger movable within the injection chamber, the plunger configured to be drawn away from the outlet to apply a vacuum force within the injection chamber;

a fluid delivery assembly configured to deliver the fluid dose to the needle-free injecting assembly, the fluid delivery assembly including;

a housing defining an interior space therein;

a cartridge defining a reservoir for containing the fluid, the cartridge constructed and arranged to be received by the interior space, the cartridge having a first end and a second end defining an outlet;

a movable piston contained within the first end of the cartridge;

a drive train for applying a force to the movable piston; and

a sensing assembly constructed and arranged to control at least the drive train; and

an adapter removably coupled to the needle-free injecting assembly and fluidly coupling the cartridge to the needle-free injecting assembly, the adapter having a fluid flow passage extending transverse to an axis extending along a length of the needle-free injecting assembly,

wherein the sensing assembly directs the drive train to apply a force to the movable piston for overcoming adhesion or static friction between the movable piston and the cartridge while the vacuum force draws the fluid dose from the cartridge through the adapter and into the injection chamber of the needle-free injecting assembly.

2. The device of claim 1, further comprising:

a magnet coupling the needle-free injecting assembly to the fluid delivery assembly.

3. The device of claim 2, wherein:

the magnet additionally provides feedback to the sensing assembly concerning whether the needle-free injecting assembly is coupled to the fluid delivery assembly.

4. The device of claim 1, further comprising:

a mechanical latch coupling the needle-free injecting assembly to the fluid delivery assembly.

5. The device of claim 1, wherein:

the sensing assembly causes the drive train to move in an opposite direction when the sensing assembly receives input concerning the operation of the needle-free injecting assembly.

6. The device of claim 5, wherein:

said input relates to an output from a sensor concerning the amount of force applied to the drive train.

7. The device of claim 5, wherein:

said input relates to an output from a sensor related to the fluid pressure during delivery from the needle-free injecting assembly to the cartridge.

8. The device of claim 1, wherein:

the sensing assembly indicates when a fluid dose below a predetermined amount remains in the cartridge.

9. The device of claim 8, wherein:

the indicating is performed by activating a visual indicator.

10. The device of claim 8, wherein:

the indicating is performed by activating an acoustical indicator.

11. The device of claim 1, wherein:

the drive train assists in transferring the fluid from both the cartridge to the needle-free injecting assembly and from the needle-free injecting assembly to the cartridge.

12. The device of claim 1, wherein:

the sensing assembly indicates when the needle-free injecting assembly is being coupled to the fluid delivery assembly.

13. The device of claim 1, wherein:

the sensing assembly indicates when the needle-free injecting assembly is being removed from the fluid delivery assembly.

14. The device of claim 13, wherein:

the drive train lessens the pressure in the cartridge in response to the indication of the sensing assembly that the needle-free injecting assembly is being removed.

15. The device of claim 1, wherein the outlet of the needle-free injecting assembly is adapted to allow discharge of the fluid dose during needle-free injection into the body of the patient, and wherein the plunger of the needle-free injecting assembly is adapted to force the fluid dose from the injection chamber through the outlet.

16. The device of claim 1, wherein the sensing assembly further comprises:

a sensor to produce an output related to the amount of the fluid dose transferred into the needle-free injecting assembly.

17. The device of claim 1, wherein:

the fluid delivery assembly positioned in a side-by-side arrangement with the needle-free injecting assembly.

18. The device of claim 1, wherein the fluid flow passage further comprises:

a first fluid passage fluidly coupled to the cartridge;

a second fluid passage adapted to be fluidly coupled to the needle-free injecting assembly; and

a third fluid passage in fluid communication between the first fluid passage and the second fluid passage, the third fluid passage extending transverse to the first and second fluid passages.

19. The device of claim 18, further comprising a piercing member containing said first fluid passage, wherein:

the second end of the cartridge being closed off using a seal;

wherein fluidly coupling said adapter to said cartridge occurs by puncturing the seal with the piercing member.

20. The device of claim 1, wherein:

the cartridge is coupled in a removable manner to said adapter.

21. A device for injecting a fluid dose into a body of a patient comprising:

a needle-free injecting assembly constructed and arranged to deliver the fluid dose into the body, the injecting assembly including;

a needle-free syringe defining an injection chamber configured to receive the fluid dose, and an outlet, and

a plunger movable within the injection chamber, the plunger configured to be drawn away from the outlet to apply a vacuum force within the injection chamber; and

a fluid delivery assembly configured to deliver the fluid dose to the injecting assembly, the fluid delivery assembly including;

a cartridge defining a reservoir for containing the fluid dose, the cartridge having a first end and a second end defining an outlet,

a movable piston contained within the first end of the cartridge,

an adapter removably coupled to the injecting assembly and fluidly coupling the cartridge to the injecting assembly, and

a powered drive train for applying a force to the movable piston for facilitating aspiration of the fluid from the cartridge while the vacuum force draws the fluid dose from the cartridge through the adapter and into the injection chamber of the injecting assembly.

22. The device of claim 21, further comprising a sensing assembly constructed and arranged to sense the force applied to the movable piston and the cartridge and to control at least the drive train to direct the drive train to apply the force to the movable piston for overcoming adhesion or static friction between the cartridge and the movable piston during delivery of the fluid from the cartridge to the injecting assembly.

23. The device of claim 21, wherein the adapter has a fluid flow passage extending transverse to an axis extending along a length the injecting assembly and is configured for positioning the fluid delivery assembly in a side-by-side arrangement with the needle-free injecting assembly.

24. A device for injecting a fluid dose into a body of a patient comprising:

a needle-free injecting assembly constructed and arranged to deliver the fluid dose into the body, the injecting assembly including;

a needle-free syringe defining an injection chamber configured to receive the fluid dose, and an outlet, and

a plunger movable within the injection chamber, the plunger configured to be drawn away from the outlet to apply a vacuum force within the injection chamber; and

a fluid delivery assembly configured to deliver the fluid dose to the injecting assembly, the fluid delivery assembly including;

a cartridge defining a reservoir for containing the fluid, the cartridge having a first end and a second end defining an outlet,

a movable piston contained within the first end of the cartridge,

an adapter removably coupled to the injecting assembly and fluidly coupling the cartridge to the injecting assembly,

a powered drive train for applying a force to the movable piston, and a sensing assembly constructed and arranged to sense the force applied to the movable piston and the cartridge and to control at least the drive train to direct the drive train to apply the force to the movable piston for overcoming adhesion or static friction between the cartridge and the movable piston while the vacuum force draws the fluid dose from the cartridge through the adapter and into the injection chamber of the injecting assembly.