Miniature apparatus and method for optical stimulation of nerves and other animal tissue

• US 7,988,688 B2
• Filed: 09/28/2006
• Issued: 08/02/2011
• Est. Priority Date: 09/21/2006
• Status: Active Grant

• Current Assignee: Nervesense Ltd
• Original Assignee: Lockheed Martin Corporation (Martin Marietta Corporation)
• Inventors: Bendett, Mark P., Webb, James S., Lemaire, Charles A., Miyake, Charles I.
• Primary Examiner(s): Johnson, III; Henry M
• Assistant Examiner(s): LIPITZ, JEFFREY BRIAN
• Application Number:
  US11/536,639
• Publication Number:
  US 20080077198A1
• Time in Patent Office: 1,769 Days
• Field of Search: 607 88- 94, 128/898
• US Class Current: 606/13
• CPC Class Codes: A61N 2005/0644 Handheld applicators
• CPC Class Codes: A61N 2005/0651 Diodes
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 5/0618 Psychological treatment
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue

Abstract

A hand-held self-contained nerve-stimulation device and method using light to provide a source of precise stimulation on one or more nerve fibers. In some embodiments, this simulation is provided through a device and method wherein a laser- or LED-light source is mounted to the handpiece. Light is passed from the light source through optical tip to simulate nerves. In some embodiments, the device is constructed from non-magnetic material such as glass, plastic or ceramics. In some embodiments, the light emanating from the optical tip can be controlled manually or automatically. In some embodiments, the handpiece contains a self-contained power source, such as batteries. In some embodiments, the handpiece is at least in part, activated by remote control in order to prevent moving the handpiece during activation. Some embodiments include a unit operable to sense a response of nerve stimulation and to suppress a laser-ablation surgery operation.

Claims

1. An apparatus comprising:

a nerve-stimulation-and-surgical unit, the nerve-stimulation-and-surgical unit including;

a first nerve-stimulation-light-emitting source that is operative to emit a first nerve-stimulation infrared optical signal at a first wavelength;

a visible-light-emitting source operative to emit a visible optical pointer signal at a second wavelength that is visible to a human and that is different than the first wavelength and that is configured to indicate a location of the first nerve-stimulation infrared optical signal;

a tissue-ablation laser source that selectively delivers a surgical pulse of optical energy that ablates animal tissue;

a beam-combining unit located in the nerve-stimulation-and-surgical unit and operatively coupled to receive the first nerve-stimulation infrared optical signal from the first nerve-stimulation-light-emitting source, the visible optical pointer signal from the visible-light-emitting source, and the surgical pulse of optical energy from the tissue-ablation laser source, and to combine and output a single combined beam containing, the first nerve-stimulation infrared optical signal from the first nerve-stimulation-light-emitting source, the visible optical pointer signal from the visible-light-emitting source, and the surgical pulse of optical energy from the tissue-ablation laser source;

an optical-delivery element located at a delivery tip of the nerve-stimulation-and-surgical unit, wherein the optical-delivery element delivers the single combined beam through the delivery tip and focuses the single combined beam onto a nerve of a subject such that the focused beam triggers a nerve-action potential response in the nerve;

a nerve-response sensor operatively coupled to the nerve-stimulation-and-surgical unit, wherein the sensor senses a nerve response of the subject and generates signal information based on the nerve response; and

control circuitry that is operatively coupled to control the first nerve-stimulation-light-emitting source, the visible-light emitting source, and the tissue-ablation laser source.

2. The apparatus of claim 1, the nerve-stimulation-and-surgical unit further comprising:

a second nerve-stimulation-light-emitting source that emits a third wavelength that directly stimulates a nerve, wherein the third wavelength is different than the first wavelength and has a different penetration depth into a given tissue than the first wavelength, and wherein light at the first wavelength is applied to achieve a first tissue-penetration depth, and light at the third wavelength is applied to achieve a second tissue-penetration depth that is different than the first tissue-penetration depth.

3. The apparatus of claim 1, further comprising:

a surgical-operation-suppression-signal generator operatively coupled to receive the signal information from the nerve-response sensor and, based on the received signal information, to generate a suppression signal for suppressing a surgical operation.

4. The apparatus of claim 3, wherein the tissue-ablation laser source is operable to deliver a surgical pulse of infrared (IR) optical energy that ablates animal tissue, and wherein the suppression signal variably reduces the surgical pulse.

5. The apparatus of claim 3, wherein the suppression signal inhibits the surgical pulse.

6. The apparatus of claim 3, wherein the suppression signal variably reduces the surgical pulse.

7. The apparatus of claim 1, wherein the beam-combining unit includes a first dichroic mirror that transmits one of the first wavelength and the second wavelength and reflects another one of the first wavelength and the second wavelength.

8. The apparatus of claim 1, wherein the beam-combining unit includes a first dichroic mirror and a second dichroic mirror.

9. The apparatus of claim 1, wherein the optical-focus element focuses to an area sufficiently small to stimulate a subset of just one or more nerves within a nerve bundle without stimulating at least another subset of the nerves in the nerve bundle.

10. The apparatus of claim 1, wherein the nerve-response sensor is located at a place other than the location of the single combined beam.

11. The apparatus of claim 1, further comprising a liquid-delivery unit configured to deliver, at the delivery tip, a liquid to the nerve of the subject.

12. The apparatus of claim 1, further comprising a focus plate at the delivery tip having a thickness such that light of the single combined beam comes to a focus at a surface of the focus plate.

13. The apparatus of claim 1, wherein the subject is a human subject and wherein the surgical pulse is configured to ablate tissue of the human subject at the focus location.

14. The apparatus of claim 1, wherein the subject is a human subject and wherein the surgical pulse is configured to cauterize tissue of the human subject at the focus location.

33. The apparatus of claim 1, wherein the optical delivery element is affixed to a disposable plastic sheath, and wherein the optical delivery element includes a lens.

34. The apparatus of claim 1, wherein the nerve-stimulation-and-surgical unit includes a substantially in-line self-contained body, and wherein the nerve-stimulation-and-surgical unit further includes a self-contained power source located within the substantially in-line body.

15. A method comprising:

providing a nerve-stimulation-and-surgical unit, the nerve-stimulation-and-surgical unit having a delivery tip, a first nerve-stimulation-light-emitting source, a second light-emitting source, and a third light-emitting source mounted in the nerve-stimulation-and-surgical unit and optics capable of combining three light signals;

obtaining, from the first nerve-stimulation-light-emitting source, a first infrared laser beam having a first wavelength that directly optically stimulates an action potential in a neural tissue of an animal subject;

obtaining user input and based on the user input, controlling the first infrared laser beam to form a optical stimulation signal;

emitting, from the second light-emitting source, a visible optical pointer signal at a second wavelength that is visible to a human, that is different than the first wavelength, and that is configured to indicate a location of the optical stimulation signal;

emitting, from the third light-emitting source, a surgical laser pulse that is configured to ablate tissue of the animal subject;

beam combining, with the optics, the first infrared laser beam, the visible optical pointer signal, and the surgical laser pulse into a single combined beam within the nerve-stimulation-and-surgical unit;

applying the single combined beam from the nerve-stimulation-and-surgical unit onto the location on the tissue for stimulation of the tissue, wherein the applying includes focusing the single combined beam through the delivery tip such that the focused single combined beam triggers a nerve-action potential response in the neural tissue;

sensing a nerve-response of the animal subject; and

controlling an operation of the nerve-stimulation-and-surgical unit based on the sensed nerve response.

16. The method of claim 15, further comprising:

emitting a third wavelength that directly stimulates a nerve, wherein the third wavelength is different than the first wavelength and has a different penetration depth into a given tissue than the first wavelength, and wherein light at the first wavelength is applied to achieve a first tissue-penetration depth, and light at the third wavelength is applied to achieve a second tissue-penetration depth.

17. The method of claim 15, further comprising:

generating signal information based on the sensed nerve response; and

suppressing a surgical operation based on the signal information from the sensed nerve response.

18. The method of claim 17, wherein the surgical operation comprises an infrared (IR) surgical laser pulse, the method further comprising:

ablating animal tissue using the IR surgical laser pulse, wherein the suppressing inhibits the IR surgical laser pulse.

19. The method of claim 17, wherein the surgical operation comprises the surgical laser pulse, the method further comprising:

ablating animal tissue of the animal subject using the surgical laser pulse, wherein the suppressing inhibits the surgical laser pulse.

20. The method of claim 17, wherein the surgical operation comprises the surgical laser pulse, the method further comprising:

ablating animal tissue of the animal subject using the surgical laser pulse, wherein the suppressing variably reduces the surgical laser pulse.

21. The method of claim 15,

wherein the beam combining includes transmitting light of one of the first wavelength and the second wavelength and reflecting light of another one of the first wavelength and the second wavelength.

22. The method of claim 15, further comprising:

dichroic beam combining, into the single combined beam, the optical stimulation signal from the first light-emitting source, the first optical pointer from the second light-emitting source, and the surgical laser pulse.

23. The method of claim 15, wherein the focusing of the optical stimulation signal further includes focusing to an area sufficiently small to stimulate a subset of just one or more nerves within a nerve bundle without stimulating at least another subset of the nerves in the nerve bundle.

24. The method of claim 15, wherein the sensing of the nerve-response is done at a place other than the location of the single combined beam.

25. The method of claim 15, the method further comprising:

ablating tissue of the animal with the surgical laser pulse.

26. The method of claim 15, the method further comprising:

cauterizing tissue of the animal with the surgical laser pulse.

27. An apparatus comprising:

a nerve-stimulation-and-surgical unit, wherein the nerve-stimulation-and-surgical unit includes a delivery tip;

means for stimulating an action potential in a neural tissue of an animal, wherein the means for stimulating includes, a first infrared laser beam having a first wavelength that directly optically stimulates the action potential in the neural tissue of the animal;

means for obtaining user input and based on the user input, controlling the first laser beam;

means for emitting a visible optical pointer signal;

means for emitting an optical signal for removing tissue to effect optical-beam surgery;

means for beam combining the first infrared laser beam, the visible optical pointer signal and the optical signal for removing tissue into a single combined beam;

means for applying and focusing the first infrared laser beam of the single combined beam through the delivery tip of the nerve-stimulation-and-surgical unit onto a location on the neural tissue for stimulation of a nerve-action potential in the neural tissue, wherein the visible optical pointer signal of the single combined beam indicates the location of the first focused infrared laser beam on the neural tissue;

means for sensing a nerve-response of the subject; and

means for controlling an operation of the nerve-stimulation-and-surgical unit based on the sensed nerve response.

28. The apparatus of claim 27, further comprising:

means for suppressing operation of the means for emitting the optical signal for removing tissue.

29. An apparatus comprising:

a light-delivery handpiece of such small size to be readily hand held by a human user, the handpiece including;

a self-contained power source;

a first infrared-light-emitting source that is powered from the self-contained power source and is operative to emit a first infrared optical signal at a first wavelength;

a visible-light-emitting source operative to emit a visible optical pointer signal at a second wavelength that is visible to a human and that is different than the first wavelength and that is configured to indicate a focus location of the first infrared optical signal;

a tissue-ablation laser source operable to deliver a surgical pulse of optical energy that ablates animal tissue;

a beam-combining unit operatively coupled to receive the first infrared optical signal from the first infrared-light-emitting source, the visible optical pointer signal from the visible-light-emitting source, and the surgical pulse from the tissue-ablation laser source, and output a single combined beam containing the first infrared optical signal, the visible optical pointer signal from the visible-light-emitting source, and the surgical pulse;

an optical-delivery element located at a delivery tip of the handpiece, wherein the optical-delivery element delivers the single combined beam through the delivery tip onto the focus location on a human subject;

a nerve-response sensor operatively coupled to the handpiece, wherein the sensor senses a nerve response of the subject and generates signal information based on the nerve response that is coupled to control an operation of the handpiece;

a controller operatively coupled to control an operation of the apparatus.

30. The apparatus of claim 29, wherein the first infrared optical signal is pulsed and configured to cause a nerve-action potential in a nerve of the human subject at the focus location.

31. The apparatus of claim 29, wherein the surgical pulse is configured to ablate tissue of the human subject at the focus location.

32. The apparatus of claim 29, wherein the surgical pulse is configured to cauterize tissue of the human subject at the focus location.