Axially-radially nested expandable device

• US 7,988,721 B2
• Filed: 12/04/2007
• Issued: 08/02/2011
• Est. Priority Date: 11/30/2007
• Status: Expired due to Fees

• Current Assignee: REVA Medical Inc.
• Original Assignee: REVA Medical Inc.
• Inventors: Sheriff, Jeffrey T., Morris, Andrew, Schmid, Eric, Esser, Keith
• Primary Examiner(s): Nguyen; Anhtuan T
• Assistant Examiner(s): EASTWOOD, DAVID C
• Application Number:
  US11/950,351
• Publication Number:
  US 20090143853A1
• Time in Patent Office: 1,337 Days
• Field of Search: 623/1.1, 623/1.11, 623/1.15, 623/1.16, 623 117- 134, 623/1.36, 623/1.37, 623/1.49
• US Class Current: 623/1.16
• CPC Class Codes: A61F 2/852 Two or more distinct overlapping stents
• CPC Class Codes: A61F 2/93 circumferentially expandable by using ratcheting locks
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2230/0058 X-shaped
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing

Abstract

Expandable medical implants for maintaining support of a body lumen are disclosed. These implants comprise an axially-radially nested, diametrically expandable, moveable vascular device for enlarging an occluded portion of a vessel. The device can be configured to allow for motion such as translating and/or slide and lock. One advantage of the axially-radially nested stent is that it maintains the expanded size, without significant recoil.

Claims

1. An offset rail stent being expandable from an axially-radially nested unexpanded state to an expanded state, the stent comprising a tubular member having a longitudinal axis, the tubular member comprising:

a plurality of linkage strands extending in generally parallel directions along the longitudinal axis, each linkage strand having a plurality of frame elements being interconnected in an end-to-end fashion via at least one interconnection element, each frame element comprising at least one rail member having a free end separate from the free ends of rail members on other frame members, each rail member extending from the frame element in a circumferential direction, each frame element further comprising at least one engagement aperture, at least one rail member extending through an engagement aperture of an adjacent linkage strand, wherein each engagement aperture and each rail member are sized such that the at least one rail member can freely pass through a respective engagement aperture; and

a plurality of coupling elements each attached to a free end of a respective rail member extending through the engagement aperture;

a plurality of engagement mechanisms, each comprising at least one of the coupling elements engaged with at least one of the engagement apertures providing one-way movement of the coupling element engaged with a rail member in an expanding direction through the engagement aperture during expansion of the stent from an axially-radially nested unexpanded state to an expanded state and resisting movement of the coupling element engaged with the rail member in a contracting direction, opposite to the expanding direction, through the engagement aperture, thereby preventing contraction of the stent toward an axially-radially nested unexpanded state.

2. The offset rail stent of claim 1, wherein each frame element has two rail members extending therefrom.

3. The offset rail stent of claim 2, wherein the coupling elements are formed in pairs.

4. The offset rail stent of claim 3, wherein the coupling elements are formed in a U-shape.

5. The offset rail stent of claim 1, wherein a given coupling element is bonded to a given rail member.

6. The offset rail stent of claim 1, wherein each linkage strand is configured with adjacent frame elements being circumferentially offset relative to each other.

7. The offset rail stent of claim 1, wherein the engagement mechanisms comprise coupling element includes a connecting means disposed thereon being configured to engage an engagement aperture of a frame element of an adjacent linkage strand.

8. The offset rail stent of claim 7, wherein the connecting means comprises a plurality of teeth disposed along a side of the coupling element.

9. The offset rail stent of claim 7, wherein the connecting means comprises a plurality of teeth disposed along a top portion of the coupling element.

10. The offset rail stent of claim 1, further comprising a plurality of scales extending from an exterior surface of at least one of the linkage strands of the tubular member to at least engage a sidewall of a body lumen.

11. The offset rail stent of claim 1, further comprising a therapeutic agent.

12. The offset rail stent of claim 11, wherein the therapeutic agent is selected from the group consisting of an antiproliferative agent, an anti-inflammatory agent, an anti-matrix metalloproteinase agent, a lipid lowering agent, a cholesterol modifying agent, an anti-thrombotic agent and an antiplatelet agent.

13. The offset rail stent of claim 12, wherein the therapeutic agent is an antiproliferative agent selected from the group consisting of Paclitaxel, Rapamycin, ABT-578, Biolimus A9, Everolimus, tacrolimus, and derivatives and analogs thereof.

14. The offset rail stent of claim 1, wherein at least one coupling element comprises a securing point and at least one rail member comprises a protrusion, wherein the protrusion is receivable by the securing point to secure the at least one coupling element to the at least one rail member.

15. The offset rail stent of claim 14, wherein the securing point comprises an aperture that extends through the coupling element.

16. The offset rail stent of claim 14, wherein the securing point comprises a cavity.

17. The offset rail stent of claim 1, wherein at least one coupling element comprises an alignment element and at least one rail member further comprises a protrusion, wherein the protrusion can be received by the alignment element.

18. The offset rail stent of claim 1, wherein at least one engagement aperture comprises a locking mechanism.

32. The stent of claim 1, further comprising a sheath.

33. The stent of claim 32, wherein the sheath comprises at least one structural pattern.

19. A radially expandable stent comprising a tubular member having a longitudinal axis, wherein the tubular member comprises:

a plurality of interwoven strands extending along the longitudinal axis, each strand having at least one frame element, each frame element comprising at least one rail member and at least one engagement aperture, the at least one rail member having a free end separate from the free ends of rail members on other frame members and extending circumferentially about the tubular member and through an engagement aperture of an adjacent strand, the at least one engagement aperture and the rail member being sized such that in a first condition the rail member can pass through the engagement aperture in both an expansion direction and a contraction direction, the contraction directing being opposite the expansion direction; and

a plurality of coupling elements each connected to a free end of respective ones of the rail members in a second condition, the coupling elements each comprising at least one securing structure and a motion-limiting structure, wherein the securing structure receives at least a portion of a respective rail member and secures the coupling element relative to the respective rail member in at least a circumferential direction, the motion-limiting structure of the coupling element engaging the engagement aperture of a respective frame element to allow one-way movement of the coupling element relative to the respective frame element in only the expansion direction of the interwoven strands with respect to each other and to resist movement of the coupling element relative to the respective frame element in the contraction direction.

20. The stent of claim 19, wherein the at least one rail member comprises a protrusion, the securing structure receiving the protrusion and thereby securing the coupling element relative to the respective rail member in at least the circumferential direction.

21. The stent of claim 20, wherein the protrusion is configured to be snap fitted into the securing structure.

22. The stent of claim 20, wherein the protrusion is configured to be press fitted into the securing structure.

23. The stent of claim 20, further comprising an adhesive that secures the protrusion to the securing structure.

24. The stent of claim 20, wherein the securing structure comprises an aperture that extends through the coupling element.

25. The stent of claim 20, wherein the securing structure comprises a cavity.

26. The stent of claim 19, wherein at least one coupling element comprises an alignment element and the at least one rail member further comprises a protrusion, wherein the protrusion is received by the alignment element and thereby interconnects the at least one coupling element with the at least one rail member.

27. The stent of claim 19, wherein each frame element comprises two rail members extending therefrom.

28. The stent of claim 19, wherein the coupling elements are formed in pairs.

29. The stent of claim 28, wherein the coupling elements are formed in a U-shape.

30. The stent of claim 19, wherein the motion-limiting structure of the coupling element comprises a plurality of teeth.

31. The stent of claim 19, wherein the interwoven strands extend generally parallel relative to each other along the longitudinal axis.

34. The stent of claim 19, further comprising a sheath.

35. The stent of claim 34, wherein the sheath comprises at least one structural pattern.