System and method for screening tissue

• US 7,993,271 B2
• Filed: 05/17/2007
• Issued: 08/09/2011
• Est. Priority Date: 09/20/2002
• Status: Expired due to Fees

• Current Assignee: Ohio State University
• Original Assignee: Ohio State University
• Inventors: Liu, Jun, Ferrari, Mauro, Rokhlin, Stanislav I., Sedmak, Daniel D.
• Primary Examiner(s): Cattungal; Sanjay
• Application Number:
  US11/750,161
• Publication Number:
  US 20070299340A1
• Time in Patent Office: 1,545 Days
• Field of Search: 600/407, 600/408, 600437-461, 601 2- 4, 604 19- 22
• US Class Current: 600/437
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/485 involving measuring strain or elastic properties

Abstract

A system and method for screening tissue is provided. The system provides a computer-based system for distinguishing between normal and potentially abnormal tissue. The system includes computer components for generating and receiving ultrasonic waves, for storing a tissue model, and for analyzing received ultrasonic waves in the context of the tissue model.

Claims

1. A tissue screening system, comprising:

an ultrasonic wave producer that produces a first ultrasonic wave directed at a tissue to be screened;

an ultrasonic wave receiver receiving a second ultrasonic wave produced as a function of the first ultrasonic wave interacting with the tissue;

an analyzer operably connected to at least one of the ultrasonic wave producer and the ultrasonic wave receiver, the analyzer identifying whether the tissue is diseased tissue based on microstructural and micromechanical properties of the tissue, as compared to microstructural and micromechanical properties of normal tissue, from analysis of the second ultrasonic wave; and

a tissue mechanical properties model, based on nanomechanics, in data communication with the analyzer, the tissue mechanical properties model processing information associated with the microstructural and micromechanical properties of normal and abnormal tissues from the second ultrasonic wave.

2. The system of claim 1, wherein the tissue mechanical properties model stores information concerning at least one of tissue reflection, tissue transmission, tissue elasticity, tissue particle size, tissue micro-architecture, and tissue micromoduli.

3. The system of claim 1, wherein the analyzer analyzes the second ultrasonic wave to characterize the mechanical reaction of the first ultrasonic wave with the tissue to facilitate identifying the tissue mechanical property which in turn facilitates determining if the tissue is one of healthy and diseased.

4. The system of claim 1, wherein the tissue mechanical properties model is based on one of a linear and non-linear viscoelastic model.

5. The system of claim 1 , wherein the tissue to be screened is one of an external tissue surface and an internal tissue surface.

6. The system of claim 1, wherein the second ultrasonic wave includes a reflected wave.

7. The system of claim 1, wherein the second ultrasonic wave includes a transmitted wave.

8. The system of claim 1, wherein the analyzer analyzes a reflection spectrum.

9. The system of claim 1, wherein the tissue is treated with a nanoparticle contrast agent before the first ultrasonic wave is directed at the tissue.

10. The system of claim 1, wherein the ultrasonic wave producer and the ultrasonic wave receiver are both located in a portable device that is passed over the tissue.

11. The system of claim 1, wherein the ultrasonic wave producer is one of a transducer and a transducer array.

12. The system of claim 1, wherein the ultrasonic wave receiver is one of a transducer and a transducer array.

13. The system of claim 1, wherein the first ultrasonic wave is in the range of about 2.5 to about 12.5 MHz, with a center frequency of about 7.5 MHz.

14. The system of claim 1, wherein the first ultrasonic wave is in a range with a lower bound between about 2 and about 7 MHz and an upper bound between about 8 and about 13 MHz.

15. A non-transitory computer readable medium storing computer executable components of the system of claim 1.

16. The system of claim 1, wherein the analyzer identifies changes in at least one of micromoduli, internodal distance, and particle size microstructures of the tissue.

17. A method for screening tissue, comprising:

directing an ultrasonic wave at a tissue to be screened;

receiving a second ultrasonic wave produced as a function of the first ultrasonic wave interacting with the tissue;

identifying, based on wave propagation mechanics, a parameter of the second ultrasonic wave associated with microstructural and micromechanical properties of the tissue;

analyzing the parameter associated with the microstructural and the micromechanical properties of the tissue;

comparing the microstructural and the micromechanical properties of the tissue with microstructural and micromechanical properties of normal tissue based on a tissue mechanical properties model, based on nanomechanics, that processes information associated with the microstructural and micromechanical properties of normal and abnormal tissues from the second ultrasonic wave; and

determining whether the tissue should be tagged as diseased tissue as a function of the parameter.

18. The method of claim 17, wherein the first ultrasonic wave has a frequency in the range of about 3 to about 13 MHz.

19. The method of claim 17, wherein the second ultrasonic wave comprises at least one of reflected waves and transmitted waves.

20. The method of claim 17, further comprising:

before directing the ultrasonic wave at the tissue, associating a nanoparticle contrast agent with the tissue.

21. The method of claim 17, wherein identifying the parameter comprises:

analyzing at least one of tissue reflection, tissue transmission, tissue elasticity, tissue particle size, tissue micromoduli, tissue micro-architecture, and tissue mechanical response properties.

22. A computer readable medium storing computer executable instructions operable to perform computer executable portions of the method of claim 17.

23. A tissue screening system, comprising:

means for generating a first ultrasonic wave;

means for directing the first ultrasonic wave at a tissue sample to be screened;

means for collecting a second ultrasonic wave produced from a mechanical interaction of the first ultrasonic wave and the tissue sample to be screened;

means for modeling one or more modeled mechanical properties of tissue, based on nanomechanics, into modeled microstructural and micromechanical properties of normal tissue based on wave propagation mechanics;

means for correlating the at least one of the microstructural and the micromechanical properties with one or more mechanical interactions between a tissue sample and an ultrasonic wave; and

means for identifying diseased regions of the tissue sample based on a comparison of the at least one of the microstructural and the micromechanical properties of the tissue with the modeled microstructural and the micromechanical properties of normal tissue.