Device and method for particle complex handling
First Claim
1. A device comprisinga fluidic network comprising a plurality of fluidic zones, each fluidic zone being connected to the adjacent zone by a diffusion barrier;
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an array of magnetic microcoils functionally coupled to the fluidic network, wherein the microcoils are programmably activatable to generate a magnetic field in proximity to each microcoil and to transport a magnetic particle in the fluidic network without fluidic movement of a fluid in the plurality of the fluidic zones;
a detection element functionally coupled to the fluidic network; and
optionally comprising a vibrational element functionally coupled to the fluidic network.
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Abstract
An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
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Citations
26 Claims
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1. A device comprising
a fluidic network comprising a plurality of fluidic zones, each fluidic zone being connected to the adjacent zone by a diffusion barrier; - and
an integrated circuitry component; an array of magnetic microcoils functionally coupled to the fluidic network, wherein the microcoils are programmably activatable to generate a magnetic field in proximity to each microcoil and to transport a magnetic particle in the fluidic network without fluidic movement of a fluid in the plurality of the fluidic zones; a detection element functionally coupled to the fluidic network; and optionally comprising a vibrational element functionally coupled to the fluidic network. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification