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Methods of treatment using anti-CD3 antibodies

  • US 7,993,641 B2
  • Filed: 10/16/2006
  • Issued: 08/09/2011
  • Est. Priority Date: 07/21/1998
  • Status: Expired due to Fees
First Claim
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1. A method of treating a patient having cancer or requiring immunosuppression comprising administering to said patient a therapeutically effective amount of an IgG antibody having a binding affinity for the CD3 antigen complex, wherein said antibody comprises:

  • a heavy chain having the amino acid sequence SEQ ID NO;

    20;

    a human lambda light chain constant region; and

    a light chain variable domain comprising three CDRs having the amino acid sequences SEQ ID NOS;

    8, 10, and 12, and four framework regions having the amino acid sequences SEQ ID NOS;

    35 26, 27, and 28,wherein alanine at amino acid 7 of SEQ ID NO;

    35 is replaced with proline.

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