Method and apparatus for in vivo collection of circulating biological components
First Claim
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1. A method for detecting disease, comprising the steps of:
- providing a binding agent attraction device;
inserting the device into a body;
introducing a binding agent into the body by injecting the binding agent into the bloodstream;
attracting at least a portion of the binding agent to the attraction device; and
assessing the binding agent attracted to the attraction device.
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Abstract
The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of the invention, active attraction of biological markers are provided. A partial or complete analytic/detection assembly may also be integrated with the probe.
51 Citations
17 Claims
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1. A method for detecting disease, comprising the steps of:
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providing a binding agent attraction device; inserting the device into a body; introducing a binding agent into the body by injecting the binding agent into the bloodstream; attracting at least a portion of the binding agent to the attraction device; and assessing the binding agent attracted to the attraction device. - View Dependent Claims (2, 3)
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4. A method for detecting disease, comprising the steps of:
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providing a binding agent attraction device; inserting the device into a body; introducing a binding agent into the body by eluting the binding agent from an implant within the body; attracting at least a portion of the binding agent to the attraction device; and assessing the binding agent attracted to the attraction device. - View Dependent Claims (5, 6)
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7. A method for detecting disease, comprising the steps of:
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providing a binding agent attraction device; inserting the device into a body; introducing a binding agent into the body by ingestion of the binding agent into the body; attracting at least a portion of the binding agent to the attraction device; and assessing the binding agent attracted to the attraction device. - View Dependent Claims (8, 9)
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10. A method for detecting disease, comprising the steps of:
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providing a binding agent attraction device; inserting the device into a body; introducing a binding agent into the body; attracting at least a portion of the binding agent to the attraction device; and assessing the binding agent attracted to the attraction device by impedance-based detection of the binding agent. - View Dependent Claims (11, 12, 13)
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14. A method for detecting disease, comprising the steps of:
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providing a binding agent attraction device; inserting the device into a body; introducing a binding agent into the body; attracting at least a portion of the binding agent to the attraction device; and assessing the binding agent attracted to the attraction device by optical detection of the binding agent. - View Dependent Claims (15, 16, 17)
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Specification