Modulators of body weight, corresponding nucleic acids and proteins

• US 7,994,301 B2
• Filed: 04/21/2009
• Issued: 08/09/2011
• Est. Priority Date: 08/17/1994
• Status: Expired due to Fees

• Current Assignee: Rockefeller University
• Original Assignee: Rockefeller University
• Inventors: Proenca, Ricardo, Friedman, Jeffrey M., Zhang, Yiying
• Primary Examiner(s): Saoud; Christine J
• Application Number:
  US12/427,410
• Publication Number:
  US 20090318677A1
• Time in Patent Office: 840 Days
• Field of Search: None
• US Class Current: 536/23.5
• CPC Class Codes: A01K 2217/05 Animals comprising random inserted nucleic acids (transgenic)
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 48/00 Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61Q 19/06 for countering cellulitis
• CPC Class Codes: C07K 14/5759 Products of obesity genes, e.g. leptin, obese (OB), tub, fat
• CPC Class Codes: C07K 16/18 against material from animals or humans
• CPC Class Codes: C07K 2319/00 Fusion polypeptide
• CPC Class Codes: C12Q 1/6883 for diseases caused by alterations of genetic material
• CPC Class Codes: C12Q 2600/156 Polymorphic or mutational markers
• CPC Class Codes: C12Q 2600/158 Expression markers
• CPC Class Codes: Y10S 930/12 Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
• CPC Class Codes: Y10S 930/14 Lymphokine; related peptides

Abstract

Modulators of weight, including, for example, two isoforms of murine and human ob polypeptides, are provided, as well as diagnostic and therapeutic uses and methods comprising such. Also provided are nucleotide sequences, degenerate variations thereof, and proteins expressed by such.

Claims

1. An isolated DNA molecule, which encodes a body weight modulator, selected from the group consisting of:

A. the DNA sequence of FIG. 1 (SEQ ID NO;

     1);

B. the DNA sequence of FIG. 2 (SEQ ID NO;

     3); and

C. a DNA sequence that codes on expression for an amino acid sequence that is selected from the group consisting of SEQ ID NO;

2 and SEQ ID NO;

4.