Devices and arrangements for performing coherence range imaging using a common path interferometer

• US 7,995,210 B2
• Filed: 11/21/2005
• Issued: 08/09/2011
• Est. Priority Date: 11/24/2004
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Bouma, Brett Eugene, Tearney, Guillermo J.
• Primary Examiner(s): Connolly; Patrick J
• Application Number:
  US11/285,301
• Publication Number:
  US 20060109478A1
• Time in Patent Office: 2,087 Days
• Field of Search: 356/477, 356/479, 356/497
• US Class Current: 356/479
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: G01B 2290/70 Using polarization in the interferometer
• CPC Class Codes: G01B 9/02004 using frequency scans
• CPC Class Codes: G01B 9/02044 Imaging in the frequency domain, e.g. by using a spectrometer
• CPC Class Codes: G01B 9/0205 of probe head
• CPC Class Codes: G01B 9/02057 by using common path configuration, i.e. reference and object path almost entirely overlapping
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence
• CPC Class Codes: G01D 5/35303 using a reference fibre, e.g. interferometric devices
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

Devices, arrangements and apparatus adapted to propagate at least one electro-magnetic radiation are provided. In particular, a probe housing, a sample arm section and a reference arm section can be included. For example, the sample arm section can be at least partially situated within the probe housing, and configured to propagate a first portion of the electro-magnetic radiation that is intended to be forwarded to a sample. The reference arm section can be at least partially situated within the probe housing, and configured to propagate a second portion of the electro-magnetic radiation that is intended to be forwarded to a reference. In addition or as an alternative, an interferometer may be situated within the probe housing. The first and second portions may travel along substantially the same paths, and the electro-magnetic radiation can be generated by a narrowband light source that has a tunable center wavelength. Further, the first and second portions may be at least partially transmitted via at least one optical fiber. A splitting arrangement may be provided which splits the electro-magnetic radiation into the first and second portions, and positioned closer to the sample than to the source of the electro-magnetic radiation, and the first and second portions may be adapted to propagate in different directions. An apparatus may be provided that is configured to control an optical path length of the second portion.

Claims

1. An arrangement adapted to propagate at least one electro-magnetic radiation at least one of to and from an anatomical sample, comprising:

a probe housing structured to be provided at or in the anatomical sample; and

a device which includes a dual-balanced common path interferometer at least partially situated within the probe housing.

2. The arrangement according to claim 1, wherein the device is situated completely within the probe housing.

3. The arrangement according to claim 1, further comprising at least one optical fiber which is at least partially situated in the probe housing.

4. The arrangement according to claim 1, further comprising a beam splitting apparatus situated within the probe housing which is structured to split the at least one electro-magnetic radiation into at least particular radiation.

5. The arrangement according to claim 4, wherein the beam splitting apparatus includes at least one of a refractive index interface, a dielectric mirror, a partially reflecting metal mirror, an inner surface of the probe housing, an outer surface of the probe housing, a cube beam splitter, a diffractive optic, or a pellicle beam splitter.

6. The arrangement according to claim 4, further comprising a beam directing element provided in a cooperation with the beam splitting apparatus, and situated within the housing which directs the at least particular radiation in a predetermined direction.

7. The arrangement according to claim 4, wherein the beam splitting apparatus includes a beam directing element.

8. The arrangement according to claim 4, further comprising a lens arrangement provided in a cooperation with the beam splitting apparatus, and situated within the housing which focuses the at least particular radiation.

9. The arrangement according to claim 4, wherein the beam splitting apparatus includes a lens arrangement.

10. The arrangement according to claim 1, wherein the at least one electro-magnetic radiation is generated by a broadband light source, and wherein a further radiation returned from the anatomical sample is received by a spectrometer apparatus.

11. The arrangement according to claim 10, further comprising

a radiation receiving arrangement which includes a non-reciprocal optical arrangement and which receives a further radiation returned from the anatomical sample, and structured to direct the further radiation to a detection apparatus.

12. The arrangement according to claim 1, wherein at least one particular radiation associated with a first portion of the at least one electro-magnetic radiation scanned across the anatomical sample.

13. The arrangement according to claim 12, wherein a further radiation received from the anatomical sample that is associated with the at least one particular radiation is forwarded to a detection and imaging apparatus for imaging at least a portion of the anatomical sample.

14. The arrangement according to claim 1, wherein the interferometer includes at least one of a Michelson interferometer, a Mach Zehnder interferometer, and a Sagnac interferometer.

15. The arrangement according to claim 1, wherein the interferometer includes a section configured to receive a first portion of the at least one electro-magnetic radiation from a sample and a second portion of the at least one electro-magnetic radiation from a reference, wherein the first and second portions travel along substantially the same path within or at the section.

16. The arrangement according to claim 1, further comprising a further arrangement is configured to generate a depth information of the anatomical sample using a frequency analysis of data for at least one signal associated with the anatomical sample.

17. The arrangement according to claim 16, wherein the frequency analysis is a Fourier Transform.

18. The arrangement according to claim 1, further comprising a further arrangement configured to generate a depth information of the anatomical sample using a frequency analysis of data for at least one signal received from the anatomical sample.

19. The arrangement according to claim 18, wherein the frequency analysis is a Fourier Transform.

20. An arrangement adapted to propagate at least one electro-magnetic radiation at least one of to and from an anatomical sample, comprising:

a probe housing structured to be provided in the anatomical sample; and

a device which is structured to be provided in the anatomical sample and including at least one of;

a common path interferometer situated within the probe housing, or

a section which is at least partially situated in the probe housing and configured to receive a first portion of the at least one electro-magnetic radiation from the anatomical sample and a second portion of the at least one electro-magnetic radiation from a reference, wherein the first and second portions travel along substantially the same path within or at the section,

wherein the probe housing is a transparent sheath.

21. An arrangement, comprising:

at least one section configured to receive a first portion of at least one electro-magnetic radiation from an anatomical sample and a second portion of the least one electro-magnetic radiation from a reference, wherein the at least one section is provided within the anatomical sample;

a detector arrangement which is structured to detect the at least one electro-magnetic radiation as a function of a wavelength of the at least one electro-magnetic radiation provided from the anatomical sample, wherein the at least one electro-magnetic radiation is generated by a narrowband light source that has a tunable center wavelength.

22. The arrangement according to claim 21, further comprising a probe housing, wherein the sample and the at least one section are at least partially situated within the probe housing.

23. The arrangement according to claim 22, wherein the at least one section is situated completely within the probe housing.

24. The arrangement according to claim 21, further comprising a beam splitting apparatus which structured to split the at least one electro-magnetic radiation into at least particular radiation associated with the first portion and the second portion.

25. The arrangement according to claim 24, wherein the beam splitting apparatus includes at least one of a refractive index interface, a dielectric mirror, a partially reflecting metal mirror, an inner surface of the probe housing, an outer surface of the probe housing, a cube beam splitter, a diffractive optic, and a pellicle beam splitter.

26. The arrangement according to claim 24, further comprising a beam directing element provided in a cooperation with the beam splitting apparatus, and which directs the at least particular radiation in a predetermined direction.

27. The arrangement according to claim 24, wherein the beam splitting apparatus includes at least one of a beam directing element or a lens arrangement.

28. The arrangement according to claim 24, further comprising a lens arrangement provided in a cooperation with the beam splitting apparatus which focuses the at least particular radiation.

29. The arrangement according to claim 21, further comprising a radiation receiving arrangement which receives a further radiation returned from the sample and the at least one section, and structured to direct the further radiation to a detection apparatus, wherein the further radiation is associated with at least one of the first portion or the second portion.

30. The arrangement according to claim 29, wherein the radiation receiving arrangement is a non-reciprocal optical element.

31. The arrangement according to claim 21, wherein at least one particular radiation associated with the first portion of the at least one electro-magnetic radiation is scanned across a sample.

32. The arrangement according to claim 31, wherein a further radiation received from the section that is associated with the at least one particular radiation is forwarded to a detection and imaging apparatus for imaging at least a portion of the sample.

33. The arrangement of claim 21, wherein the first and second portions are at least partially transmitted via at least one optical fiber.

34. The arrangement according to claim 21, further comprising a further arrangement is configured to generate a depth information of the anatomical sample using a frequency analysis of data for at least one of the first section or the second section.

35. The arrangement according to claim 34, wherein the frequency analysis is a Fourier Transform.

36. The arrangement according to claim 21, wherein the first and second portions travel along paths that are separate and different from one another within or at the at least one section.

37. An arrangement, comprising:

at least one section configured to receive a first portion of at least one electro-magnetic radiation from an anatomical sample and a second portion of the least one electro-magnetic radiation from a reference; and

a probe housing, wherein the sample and the at least one section are situated within the probe housing,

wherein the first and second portions travel along substantially the same path within or at the at least one section,

wherein the at least one electro-magnetic radiation is generated by a narrowband light source that has a tunable center wavelength, and

wherein the probe housing is a transparent sheath.

38. An arrangement adapted to propagate at least one electro-magnetic radiation, comprising:

a splitting arrangement which splits at least one electro-magnetic radiation into a first portion and a second portion;

a first section structured to propagate the first portion that is intended to be forwarded to an anatomical sample;

a second section structured to propagate the second portion to a reference, wherein the first and second sections are provided within the anatomical sample;

a detector arrangement which is structured to detect at least one further radiation associated with the at least one electro-magnetic radiation and to generate at least one signal as a function of a wavelength of a combination of the first and second portions of the at least one electro-magnetic radiation; and

a further arrangement which is configured to determine depth information of the anatomical sample based on the at least one signal,

wherein the splitting arrangement is positioned closer to the sample than to a source of the at least one electro-magnetic radiation, and wherein the first and second sections are structured to propagate the respective first and second portions in different directions.

39. The arrangement according to claim 38, further comprising a probe housing, wherein the first and second sections are at least partially situated within the probe housing.

40. The arrangement according to claim 39, wherein the first section is situated completely within the probe housing.

41. The arrangement according to claim 38, further comprising at least one optical fiber associated with the first and second sections, wherein at least one section of the first portion and at least one section of the second portion travel along the at least one optical fiber.

42. The arrangement according to claim 38, wherein the further arrangement is configured to generate the depth information using a frequency analysis of data for at least one signal.

43. The arrangement according to claim 42, wherein the frequency analysis is a Fourier Transform.

44. The arrangement according to claim 38, wherein the first and second portions travel along paths which are separate and different from one another at or within the respective first and second sections.

45. An arrangement adapted to propagate at least one electro-magnetic radiation, comprising:

at least one section configured to receive a first portion of the at least one electro-magnetic radiation from an anatomical sample and a second portion of the at least one electro-magnetic radiation from a reference, wherein the at least one section is provided within the anatomical sample;

a device which includes

a particular apparatus configured to control an optical path length of the second portion; and

a detector arrangement which is structured to detect the at least one electro-magnetic radiation as a function of a wavelength of the at least one electro-magnetic radiation provided from the device.

46. The arrangement according to claim 45, wherein the first and second portions travel along paths which are separate and different from one another.

47. The arrangement according to claim 45, further comprising a detection apparatus which is structured to detect at least one first resultant radiation from a first optical path length of the second portion, and at least one second resultant radiation from a second optical path length of the second portion.

48. The arrangement according to claim 47, further comprising a processing arrangement which determines a complex spectral density based on the first and second resultant radiations obtained from the detection apparatus.

49. The arrangement according to claim 47, further comprising at least one translating apparatus which is structured to control the optical path length of the second portion by mechanically translating a particular arrangement associated with the reference.

50. The arrangement according to claim 49, wherein the at least one translating apparatus comprises a further apparatus which mechanically translates the particular arrangement, the further apparatus including at least one of a linear translator or a piezoelectric transducer.

51. The arrangement according to claim 47, wherein the optical path length of the second portion is further controlled by altering a refractive index of a material associated with the reference.

52. The arrangement according to claim 51, further comprising an additional apparatus which alters the refractive index of the material, the additional apparatus including an electro-optic or acousto-optic device.

53. The arrangement according to claim 45, further comprising a probe housing, wherein the at least one section is at least partially situated within the probe housing.

54. The arrangement according to claim 45, wherein at least one particular radiation associated with the first portion of the at least one electro-magnetic radiation is scanned across a sample.

55. The arrangement according to claim 54, wherein a further radiation received from the section that is associated with the at least one particular radiation is forwarded to a detection and imaging apparatus for imaging at least a portion of the sample.

56. The arrangement according to claim 55, further comprising at least two optical fibers each adapted to propagate one of the further radiation.

57. The arrangement according to claim 55, further comprising an optical fiber adapted to propagate the further radiation.

58. The arrangement according to claim 45, further comprising at least one dual balanced receiver which detects an interference between at least one first radiation associated with the at least one first portion and at least one second radiation associated with the at least one second portion.

59. An arrangement adapted to propagate at least one electro-magnetic radiation, comprising:

at least one section configured to receive a first portion of the at least one electro-magnetic radiation from an anatomical sample and a second portion of the at least one electro-magnetic radiation from a reference, wherein the at least one section is provided within the anatomical sample; and

a device which includes

a particular apparatus configured to control an optical path length of the second portion.

60. The arrangement according to claim 59, wherein the first and second portions travel along paths which are separate and different from one another.

61. An arrangement adapted to propagate at least one electro-magnetic radiation, comprising:

at least one section configured to receive a first portion of the at least one electro-magnetic radiation from an anatomical sample and a second portion of the at least one electro-magnetic radiation from a reference, wherein the at least one section is provided within the anatomical sample; and

a device which includes a particular apparatus configured to control an optical path length of the second portion.

62. The arrangement according to claim 61, wherein the first and second portions travel along paths which are separate and different from one another.

63. The arrangement according to claim 61, further comprising a splitting apparatus which is provided in the anatomical sample, and which splits the at least one electro-magnetic radiation into two sections, one of which is associated with the first portion and another one of which is associated with the second portion, wherein the splitting apparatus is configured to receive the first and second portions as a resulting radiation, and further split the resultant radiation into at least two further radiation portions;

and further comprising;

an arrangement which includes at least one of;

at least two optical fibers each adapted to propagate one of the further radiation portions,

an optical fiber adapted to propagate the further radiation portions, and

at least one dual balanced receiver which detects an interference between at least one first radiation associated with the at least one first portion and at least one second radiation associated with the at least one second portion.

64. An arrangement, comprising:

a) at least one section configured to receive a first portion of at least one electro-magnetic radiation from an anatomical sample and a second portion of the at least one electro-magnetic radiation from a reference to generate a further signal, wherein the at least one section is provided within the anatomical sample; and

b) a spectral separating unit which splits the further signal into a plurality of optical frequencies; and

c) a plurality of detectors, each of the detectors being structured to detect at least a portion of the optical frequencies received from the spectral separating unit; and

d) an arrangement which is configured to determine depth information of the anatomical sample based on the optical frequencies.

74. The arrangement according to claim 64, wherein the first and second portions travel paths which are separate and different from one another within or at the at least one section.

65. An apparatus adapted to propagate at least one electro-magnetic radiation at least one of to and from an anatomical sample, comprising:

a probe housing structured to be provided in the anatomical sample; and

an interferometer arrangement situated within the probe housing, wherein the interferometer arrangement includes a reference arm and a sample arm, and wherein a path of at least one of the reference arm or a sample arm contains a further arrangement which has a refractive index that at least approximately matches a refractive index of at least one portion of the anatomical sample.

66. The apparatus according to claim 65, further comprising:

a detector arrangement which is structured to detect an auto-correlation signal of the at least one electro-magnetic radiation and generate at least one signal as a function of a wavelength of the at least one electro-magnetic radiation provided from the anatomical sample; and

a further arrangement which is configured to determine depth information of the anatomical sample based on the at least one signal.

67. The apparatus according to claim 65, wherein the interferometer arrangement includes at least one arrangement which is configured to receive at least one first radiation of the at least one electro-magnetic radiation from a reference arm and at least one further radiation of the at least one electro-magnetic radiation from the anatomical sample, wherein the at least one further arrangement is further configured to interfere the first and second signals, and generate data associated with the anatomical sample based on the interference of the first and second radiations.

68. An arrangement adapted to propagate at least one electro-magnetic radiation at least one of to and from an anatomical sample, comprising:

a probe housing structured to be provided at or in the anatomical sample;

a detector arrangement which is structured to detect an auto-correlation signal of the at least one electro-magnetic radiation and generate at least one signal as a function of a wavelength of the at least one electro-magnetic radiation provided from the anatomical sample; and

a further arrangement which is configured to determine depth information of the anatomical sample based on the at least one signal.

69. The apparatus according to claim 68, further comprising an interferometer arrangement situated within the probe housing, wherein the interferometer arrangement includes a reference arm and a sample arm, and wherein a path of at least one of the reference arm or a sample arm contains a further arrangement which has a refractive index that at least approximately matches a refractive index of at least one portion of the anatomical sample.

70. The apparatus according to claim 68, further comprising at least one arrangement which is configured to receive at least one first radiation of the at least one electro-magnetic radiation from a reference arm and at least one further radiation of the at least one electro-magnetic radiation from the anatomical sample, wherein the at least one further arrangement is further configured to interfere the first and second signals, and generate data associated with the anatomical sample based on the interference of the first and second radiations.

71. An apparatus adapted to propagate at least one particular electro-magnetic radiation at least one of to and from an anatomical sample, comprising:

at least one first arrangement which is configured to receive at least one first radiation of the at least one particular electro-magnetic radiation and at least one further radiation of the at least one particular electro-magnetic radiation from the anatomical sample, wherein the at least one first arrangement is further configured to interfere the first and second radiations, and generate data associated with the anatomical sample based on the interference of the first and second radiations; and

at least one second arrangement which is configured to determine depth information of the anatomical sample based on the data.

72. The apparatus according to claim 71, further comprising

a probe housing structured to be provided at or in the anatomical sample;

a detector arrangement which is structured to detect an auto-correlation signal of the at least one particular electro-magnetic radiation and generate at least one signal as a function of a wavelength of the at least one particular electro-magnetic radiation provided from the anatomical sample; and

a further arrangement which is configured to determine depth information of the anatomical sample based on the at least one signal.

73. The apparatus according to claim 72, further comprising an interferometer arrangement situated within the probe housing, wherein the interferometer arrangement includes a reference arm and a sample arm, and wherein a path of at least one of the reference arm or a sample arm contains a further arrangement which has a refractive index that at least approximately matches a refractive index of at least one portion of the anatomical sample.