Monitoring physiological activity using partial state space reconstruction
First Claim
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1. A machine-implemented method comprising:
- obtaining a physiological signal of a biological system of an organism;
generating a transformed signal that is mathematically orthogonal to the physiological signal by applying a frequency-independent transform to the physiological signal;
producing, from the physiological signal and the transformed signal, a partial state space representing dynamics of the biological system, the partial state space being a partial reconstruction of a state space representing system dynamics for the biological system; and
identifying physiological information concerning the organism based on an analysis of signal morphology in the partial state space;
wherein the producing and the identifying are performed by one or more data processing apparatus.
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Abstract
Systems and techniques relating to monitoring physiological activity using partial state space reconstruction. In general, in one aspect, a partial state space is produced using an orthogonal, frequency-independent transform, such as Hilbert transform. The partial state space can then be analyzed using state space techniques to identify physiological information for the biological system. The described techniques can be implemented in a distributed cardiac activity monitoring system, including a cardiac monitoring apparatus, and a QRS detector thereof.
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Citations
51 Claims
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1. A machine-implemented method comprising:
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obtaining a physiological signal of a biological system of an organism; generating a transformed signal that is mathematically orthogonal to the physiological signal by applying a frequency-independent transform to the physiological signal; producing, from the physiological signal and the transformed signal, a partial state space representing dynamics of the biological system, the partial state space being a partial reconstruction of a state space representing system dynamics for the biological system; and identifying physiological information concerning the organism based on an analysis of signal morphology in the partial state space; wherein the producing and the identifying are performed by one or more data processing apparatus. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A software product tangibly embodied in a machine-readable medium, the software product comprising instructions operable to cause data processing apparatus to perform operations comprising:
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obtaining a physiological signal of a biological system of an organism; generating a transformed signal that is mathematically orthogonal to the physiological signal by applying a frequency-independent transform to the physiological signal; producing, from the physiological signal and the transformed signal, a partial state space representing dynamics of the biological system, the partial state space being a partial reconstruction of a potential full state space for the biological system; and identifying physiological information concerning the organism based on an analysis of signal morphology in the partial state space. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A cardiac monitoring apparatus comprising:
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an ECG input element; a state space transformation component responsive to an output of the ECG input element and configured to generate a transformed signal that is mathematically orthogonal to a physiological signal, for a biological system of an organism, by applying a frequency-independent transform to the physiological signal; and a QRS identification component responsive to an output of the state space transformation component, the QRS identification component comprising one or more dynamical quantity calculators that each produce a value derived from a combination of the physiological signal and the transformed signal in a partial state space representing dynamics of the biological system, the partial state space being a partial reconstruction of a state space representing system dynamics for the biological system.
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24. A cardiac monitoring apparatus comprising:
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an ECG input element; a state space transformation component responsive to an output of the ECG input element; and a QRS identification component responsive to an output of the state space transformation component, the QRS identification component comprising one or more dynamical quantity calculators; the apparatus further comprising a pQRST parameter averaging component coupled with the QRS identification component, a noise estimator responsive to the output of the ECG input element, and final QRS decision logic coupled with the QRS identification component, the pQRST parameter averaging component and the noise estimator. - View Dependent Claims (25, 26, 27)
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28. A system comprising:
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an ECG input element; a state space transformation component responsive to an output of the ECG input element and configured to generate a transformed signal that is mathematically orthogonal to a physiological signal, for a biological system of an organism, by applying a frequency-independent transform to the physiological signal; a QRS identification component responsive to an output of the state space transformation component, the QRS identification component comprising one or more dynamical quantity calculators that each produce a value derived from a combination of the physiological signal and the transformed signal in a partial state space representing dynamics of the biological system, the partial state space being a partial reconstruction of a state space representing system dynamics for the biological system; and an antenna coupled with the QRS identification component and configured to wirelessly transmit physiological information. - View Dependent Claims (29)
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30. A system comprising:
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an ECG input element; a state space transformation component responsive to an output of the ECG input element; a QRS identification component responsive to an output of the state space transformation component, the QRS identification component comprising one or more dynamical quantity calculators; an antenna coupled with the QRS identification component and configured to wirelessly transmit physiological information; and a monitoring station configured to receive the transmitted physiological information, the system further comprising a pQRST parameter averaging component coupled with the QRS identification component, a noise estimator responsive to the output of the ECG input element, and final QRS decision logic coupled with the QRS identification component, the pQRST parameter averaging component and the noise estimator. - View Dependent Claims (31, 32, 33)
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34. A machine-implemented method comprising:
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obtaining a cardiac signal of a heart; translating the cardiac signal into an embedding space that represents coarse-grained dynamics of the heart, said translating comprising applying Hilbert transform to the cardiac signal; and employing state space analysis techniques to extract physiological information for the heart from the embedding space; wherein the translating and the employing are performed by one or more data processing apparatus. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42)
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43. A software product tangibly embodied in a machine-readable medium, the software product comprising instructions operable to cause one or more data processing apparatus to perform operations comprising:
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obtaining a cardiac signal of a heart; translating the cardiac signal into an embedding space that represents coarse-grained dynamics of the heart, said translating comprising applying Hilbert transform to the cardiac signal; and employing state space analysis techniques to extract physiological information for the heart from the embedding space. - View Dependent Claims (44, 45, 46, 47, 48, 49, 50, 51)
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Specification