Systems and methods for replacing signal artifacts in a glucose sensor data stream
First Claim
1. In a glucose sensing system comprising a glucose sensor configured for producing an output representative of glucose concentration in a host and processing circuitry configured to process the output, a method for processing data from the output, the method comprising:
- generating at least one data stream from the glucose sensor output;
detecting a severity of a signal artifact in the at least one data stream based at least in part on a data stream content; and
generating, using a signal estimation module, at least one estimated data stream or data stream portion for transmission or display, wherein the at least one estimated data stream is estimated based on one of a plurality of predetermined estimation algorithms, wherein the one of a plurality of predetermined estimation algorithms used for the at least one estimated data stream is selected from the plurality of predetermined estimation algorithms based on a comparison of the severity of the detected signal artifact against one or more predetermined thresholds.
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Abstract
Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
646 Citations
48 Claims
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1. In a glucose sensing system comprising a glucose sensor configured for producing an output representative of glucose concentration in a host and processing circuitry configured to process the output, a method for processing data from the output, the method comprising:
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generating at least one data stream from the glucose sensor output; detecting a severity of a signal artifact in the at least one data stream based at least in part on a data stream content; and generating, using a signal estimation module, at least one estimated data stream or data stream portion for transmission or display, wherein the at least one estimated data stream is estimated based on one of a plurality of predetermined estimation algorithms, wherein the one of a plurality of predetermined estimation algorithms used for the at least one estimated data stream is selected from the plurality of predetermined estimation algorithms based on a comparison of the severity of the detected signal artifact against one or more predetermined thresholds. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A glucose sensor system for monitoring a glucose concentration in a host, the system comprising:
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a continuous glucose sensor configured to produce a data stream; a signal artifact detection module configured to detect a severity of a signal artifact in the data stream based at least in part on data stream content; and a signal estimation module configured to generate an estimated data stream or data stream portion for transmission or display, wherein the at least one estimated data stream is estimated based on one of a plurality of predetermined estimation algorithms, wherein the one of a plurality of predetermined estimation algorithms used for the at least one estimated data stream is selected from the plurality of predetermined estimation algorithms based on a comparison of the severity of the signal artifact against one or more predetermined thresholds. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. In a glucose sensing system comprising a glucose sensor configured for producing an output representative of glucose concentration in a host and processing circuitry configured to process the output, a method for processing data from the output, the method comprising:
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processing, using the processing circuitry, the output from the glucose sensor, the processing comprising (i) detecting a severity of a signal artifact associated with data points of the output, and (ii) replacing data points of the output associated with the detected signal artifact with estimated data points, wherein a first estimation algorithm is used for generating the estimated data points if the severity of the detected signal artifact falls within a first severity range and wherein a second, different estimation algorithm is used for generating the estimated data points if the severity falls within a second, different severity; and displaying the processed output on a display device. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43)
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44. A glucose sensing system comprising:
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a continuous glucose sensor; signal artifact detection circuit configured to detect a level of severity of signal artifacts in the output based at least in part on output content processing circuitry configured to produce a data stream from an output of the continuous glucose sensor; and a display device configured to display the data stream, wherein the processing circuit is configured to process the output using a first estimation algorithm to generate a first portion of the data stream when a signal artifact having a first severity level is detected and wherein the processing circuitry is configured to process the output using a second, different estimation algorithm to generate a second portion of the data stream when a signal artifact having a second, different severity level is detected. - View Dependent Claims (45, 46, 47, 48)
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Specification