Tissue extraction and maceration device

• US 7,998,086 B2
• Filed: 09/29/2009
• Issued: 08/16/2011
• Est. Priority Date: 09/11/2003
• Status: Active Grant

• Current Assignee: DePuy Mitek Incorporated (Johnson & Johnson)
• Original Assignee: DePuy Mitek Incorporated (Johnson & Johnson)
• Inventors: Boock, Robert J., Cauldwell, Nathan S., Orr, Keith M.
• Primary Examiner(s): HOEKSTRA, JEFFREY GERBEN
• Application Number:
  US12/569,165
• Publication Number:
  US 20100022915A1
• Time in Patent Office: 686 Days
• Field of Search: 600562-571, 606 79- 85
• US Class Current: 600/566
• CPC Class Codes: A61B 10/025 for taking bone, bone marrow or cartilage samples
• CPC Class Codes: A61B 10/0266 means for severing sample
• CPC Class Codes: A61B 10/0283 with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe A61B10/025, A61B10/0266 take precedence
• CPC Class Codes: A61B 17/32002 with continuously rotating, oscillating or reciprocating cutting instruments

Abstract

Devices and methods are provided for extracting and macerating tissue, and optionally for depositing the tissue onto a tissue scaffold. The device generally includes an outer tube having a substantially open distal end that is adapted to be placed on and preferably to form a seal with a tissue surface, and a shaft rotatably disposed within the outer tube and movable between a first, proximal position in which the shaft is fully disposed within the outer tube, and a second, distal position in which a portion of a distal end of the shaft extends through the opening in the distal end of the outer tube. The device also includes a tissue harvesting tip formed on the distal end of the shaft that is effective to excise a tissue sample when the shaft is moved to the distal position, and a cutting member that is coupled to the shaft at a position proximal to the tissue harvesting tip. The cutting member is effective to macerate a tissue sample excised by the tissue harvesting tip.

Claims

1. A method for harvesting a tissue sample, comprising:

providing a tissue extraction and preparation device having an outer tube with an open distal end, and a shaft rotatably disposed within the outer tube and including a tissue harvesting tip formed on the distal end thereof and a cutting member coupled to the shaft at a position proximal to the tissue harvesting tip;

coupling a proximal end of the shaft to a driver mechanism;

positioning the open distal end of the outer tube against a tissue surface at a desired tissue sample site;

actuating the driver mechanism to effect rotation of the shaft within the outer tube;

moving the shaft from a proximal position, wherein the harvesting tip of the shaft is disposed within the outer tube, to a distal position, wherein the harvesting tip extends distally from the outer tube to penetrate the tissue surface, thereby causing the harvesting tip to obtain a tissue sample;

returning the shaft to the proximal position wherein the tissue sample is macerated by the cutting member; and

coupling the outer tube to a tissue dispensing device that is effective to deposit the macerated tissue sample onto a tissue scaffold for subsequent growth.

2. The method of claim 1, further comprising the step of coupling the outer tube to a vacuum pump that is effective to draw the macerated tissue sample through at least a portion of the outer tube.

3. The method of claim 1, wherein the device further includes a biasing element that is effective to bias the shaft to the proximal position.

4. The method of claim 3, wherein the device further includes a trigger mechanism that, upon actuation, is effect to overcome the biasing force to move the shaft from the proximal position to the distal position.

5. The method of claim 1, wherein the macerated tissue passes through a sizing screen before being deposited onto the tissue scaffold.

6. The method of claim 1, wherein the tissue cut by the tissue harvesting tip is larger than the tissue macerated by the cutting member.

7. A method for harvesting a tissue sample, comprising:

positioning an outer tube of a tissue extraction and preparation device against a tissue surface at a desired tissue sample site, the tissue extraction and preparation device having a shaft rotatably disposed within the outer tube;

actuating an actuation mechanism of the device to move the shaft distally relative to the tissue extraction and preparation device such that a distal end of the shaft extends distally past a distal end of the outer tube; and

actuating a driver mechanism to excise a tissue sample with a tissue harvesting tip disposed on the shaft, wherein the excised tissue sample is macerated with a cutting member coupled to the shaft proximal to the tissue harvesting tip and is deposited for subsequent growth in a collection device coupled to the tissue extraction and preparation device.

8. The method of claim 7, wherein actuating the actuation mechanism moves the shaft from a position wherein the tissue harvesting tip of the shaft is disposed within the outer tube to a position wherein the tissue harvesting tip extends distally from the outer tube to penetrate the tissue surface.

9. The method of claim 7, further comprising actuating the actuation mechanism to move the shaft proximally relative to the tissue extraction and preparation device such that the distal end of the shaft is disposed within the outer tube.

10. The method of claim 9, wherein the excised tissue sample is macerated with the cutting member while the distal end of the shaft is disposed within the outer tube.

11. The method of claim 7, wherein the driver mechanism coupled to a proximal end of the shaft rotates the shaft during tissue excising and maceration.

12. The method of claim 7, wherein actuating the actuation mechanism of the device to move the shaft distally relative to the tissue extraction and preparation device includes actuating a trigger mechanism that, upon actuation, is effect to overcome a proximal biasing force to move the shaft distally.

13. A method for harvesting a tissue sample, comprising:

actuating a trigger mechanism to move a shaft distally relative to the trigger mechanism and relative to an outer tube disposed around the shaft; and

actuating a driver mechanism to rotate the shaft relative to the outer tube such that a tissue harvesting tip contacts tissue to excise a tissue sample, wherein the excised tissue is passed proximally through a cutting element coupled to the shaft proximal to the tissue harvesting tip and macerated by the cutting element for deposition on a tissue scaffold for subsequent growth.

14. The method of claim 13, further comprising actuating the trigger mechanism to move the shaft proximally relative to the trigger mechanism and relative to the outer tube after a tissue sample is excised by the tissue harvesting tip.

15. The method of claim 13, wherein the macerated tissue sample is passed through a sizing screen before deposition onto a tissue scaffold.

16. The method of claim 13, wherein a proximal end of the shaft is coupled to the driver mechanism for rotation thereof.

17. The method of claim 13, wherein actuating the trigger mechanism to move the shaft distally includes moving the shaft from a proximal position, wherein the harvesting tip of the shaft is disposed within the outer tube, to a distal position, wherein the harvesting tip extends distally from the outer tube to penetrate the tissue surface, thereby causing the harvesting tip to obtain a tissue sample.

18. The method of claim 13, further comprising actuating a vacuum pump coupled to the outer tube to draw the excised tissue sample proximally through the cutting element.

19. The method of claim 13, wherein the cutting element remains within the outer tube while the tissue is excised by the tissue harvesting tip.