Devices and methods for body fluid flow control in extracorporeal fluid treatment

• US 7,998,101 B2
• Filed: 09/24/2007
• Issued: 08/16/2011
• Est. Priority Date: 07/28/2003
• Status: Expired due to Fees

• Current Assignee: Renal Solutions, Inc. (Fresenius Medical Care AG)
• Original Assignee: Renal Solutions, Inc. (Fresenius Medical Care AG)
• Inventors: Ash, Stephen R.
• Primary Examiner(s): Deak; Leslie R
• Application Number:
  US11/860,026
• Publication Number:
  US 20080177216A1
• Time in Patent Office: 1,422 Days
• Field of Search: 604/4.01, 604/5.01, 604/5.04, 604/6.09, 604/6.11, 604 65- 67, 210/645, 210/646, 210/90, 210/739, 210/416.1, 417/118, 417/140, 417/477.1, 417/437, 417/277, 417/274, 417/275, 417/286, 417/297, 417/298, 417/475, 417/521, 417/477.12, 417/395
• US Class Current: 604/6.11
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3663 Flow rate transducers; Flow integrators
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 60/113 in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/268 the displacement member being flexible, e.g. membranes, diaphragms or bladders
• CPC Class Codes: A61M 60/37 Haemodialysis, haemofiltration or diafiltration
• CPC Class Codes: A61M 60/43 using vacuum at the blood pump, e.g. to accelerate filling
• CPC Class Codes: A61M 60/523 using blood flow data, e.g. from blood flow transducers
• CPC Class Codes: A61M 60/554 of blood pressure

Abstract

Disclosed are devices and methods for the control of body fluid flow in the extracorporeal treatment of body fluid. Body fluid flow through on of a body fluid flow circuit 10, 50, 60 100, or 250 is controlled by alternatingly applying vacuum pressure and positive pressure to the circuit through a pumping chamber 30, 51, 66, 102, or 200 coordinated with flow control valves 40, 42, 44, 62, 114, 116, 118, and 120 to effect a net downstream flow of body fluid through the circuit.

Claims

1. A body fluid treatment apparatus comprising:

a body fluid pumping chamber containing a flexible membrane that is configured to draw body fluid into the pumping chamber under negative gaseous pressure on a gas side of the membrane and alternately to expel body fluid from the pumping chamber under positive gaseous pressure on the gas side of the membrane;

a sensor that is configured to provide a flow rate signal representing the flow rate of body fluid flowing into the pumping chamber; and

a control apparatus that is configured to pressurize the pumping chamber on the gas side of the membrane alternately with positive and negative gaseous pressure with reference to the flow rate signal by a) pressurizing the gas side with negative gaseous pressure and b) switching the gaseous pressure at the gas side from negative to positive upon determining that the flow rate into the pumping chamber has decreased in an amount that is predetermined to result from greater flow resistance as the pumping chamber reaches capacity at a desired cycle volume.

2. An apparatus as defined in claim 1 further comprising a dialyzer and a blood flow circuit, wherein the blood flow circuit is configured to convey blood from a patient to the pumping chamber under the influence of the negative gaseous pressure at the pumping chamber, and to convey blood from the pumping chamber through the dialyzer and back to the patient under the influence of the positive gaseous pressure at the pumping chamber.

3. An apparatus as defined in claim 1 wherein the pumping chamber is one of two body fluid pumping chambers, each of which contains a flexible membrane that is configured to draw body fluid into the respective pumping chamber under negative gaseous pressure on a gas side of the membrane and alternately to expel body fluid from the respective pumping chamber under positive gaseous pressure on the gas side of the membrane;

and wherein the control apparatus is configured to pressurize the two pumping chambers alternately with positive and negative gaseous pressure on the gas sides of the membranes to move body fluid through the two pumping chambers in a coordinated relationship.

4. An apparatus as defined in claim 3 wherein the coordinated relationship is in phase.

5. An apparatus as defined in claim 3 wherein the coordinated relationship is out of phase.

6. An apparatus as defined in claim 5 wherein the coordinated relationship is out of phase by about 180 degrees.

7. An apparatus as defined in claim 3 wherein the two pumping chambers are in parallel.

8. An apparatus as defined in claim 3 wherein the two pumping chambers are in series.

9. An apparatus as defined in claim 3 further comprising a dialyzer and a blood flow circuit, wherein the blood flow circuit is configured to convey blood from a patient to the pumping chambers under the influence of the negative gaseous pressure at the pumping chambers, and to convey blood from the pumping chambers through the dialyzer and back to the patient under the influence of the positive gaseous pressure at the pumping chambers.