Endoprostheses

• US 7,998,192 B2
• Filed: 05/09/2008
• Issued: 08/16/2011
• Est. Priority Date: 05/09/2008
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Arcand, Ben, Atanasoska, Liliana, Warner, Robert W., Radhakrishnan, Rajesh
• Primary Examiner(s): McDermott; Corrine M
• Assistant Examiner(s): PRESTON, REBECCA STRASZHEIM
• Application Number:
  US12/117,932
• Publication Number:
  US 20090281613A1
• Time in Patent Office: 1,194 Days
• Field of Search: 623/1.15, 623/1.34, 623/1.46, 623/1.38, 623/1.42
• US Class Current: 623/1.15
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes
• CPC Class Codes: A61F 2250/0031 made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 31/022 Metals or alloys
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

An endoprosthesis includes a body defining a flow passage therethrough. The body is capable of maintaining patency in a blood vessel and includes iron or an alloy thereof. The body has a nano-structured surface comprising iron oxide in which the individual nano-structures have a height to thickness aspect ratio of at least 5:1.

Claims

1. An endoprosthesis comprising a body defining a flow passage therethrough, the body capable of maintaining patency in a blood vessel, the body comprising iron or an alloy thereof, the body having a nano-structured surface comprising iron oxide in which the individual nano-structures have a height to thickness aspect ratio of at least 5:

1, wherein the individual nano-structures have a height of about 100-300 nm.

2. The endoprosthesis of claim 1, wherein the height to thickness aspect ratio is between 10:

1 and 20;

1.

3. The endoprosthesis of claim 1, wherein the individual nano-structures have a rice grain structure having a diameter of between about 5 nm to 50 nm.

4. The endoprosthesis of claim 1, wherein an average separation distance between adjacent individual nano-structures is between about 1 nm and 50 nm.

5. The endoprosthesis of claim 1, wherein the surface has a Sdr of between 120 and 200.

6. The endoprosthesis of claim 1, wherein the surface has a resistance to corrosion of less than 5 Kohms.

7. The endoprosthesis of claim 1, further comprising a polymer coating over at least a portion of the nano-structured surface.

8. The endoprosthesis of claim 7, wherein the polymer coating comprises a co-block polymer of polyglutamic acid and a polymer selected from the group consisting of poly(ethylene oxide), polycaprolactam, poly(lactic-co-glycolic acid), polysaccharides, or combinations thereof.

9. The endoprosthesis of claim 8, wherein the polymer comprises a co-block polymer of polyglutamic acid and a non-ionic polysaccharide.

10. The endoprosthesis of claim 9, wherein the non-ionic polysaccharide is pullulan.

11. The endoprosthesis of claim 7, wherein the polymer coating is a drug eluting coating comprising a therapeutic agent.

12. The endoprosthesis of claim 1, wherein the endoprosthesis is bioerodible.

13. The endoprosthesis of claim 1, wherein the endoprosthesis is a stent.

14. The endoprosthesis of claim 1, wherein the individual nano-structures have a thickness of about 10-15 nm.

15. The endoprosthesis of claim 14, wherein the individual nano-structure have a rice grain structure having a diameter of about 10-15 nm.

16. The endoprosthesis of claim 14, wherein the individual nano-structures have a flake structure each having a width of about 200-400 nm.

17. An endoprosthesis comprising a body defining a flow passage therethrough, the body capable of maintaining patency in a blood vessel, the body comprising iron or an alloy thereof, the body having a nano-structured surface comprising iron oxide in which the individual nano-structures have a height to thickness aspect ratio of at least 5:

1, wherein the individual nano-structures have a height of between about 50 nm to about 500 nm, wherein the individual nano-structures have a flake structure each having a width of at least twice the thickness, wherein the thickness of each individual nano-structure is between about 5 nm to 50 nm and the width of each individual nano-structure is between about 100 nm to 500 nm.

18. An endoprosthesis comprising a body defining a flow passage therethrough, the body capable of maintaining patency in a blood vessel, the body comprising iron or an alloy thereof, the body having a surface comprising iron oxide, the endoprosthesis comprising a coating over the surface, the coating comprising a co-block polymer of polyglutamic acid.

19. The endoprosthesis of claim 18, wherein the co-block polymer of polyglutamic acid is a co-block polymer of polyglutamic acid and of a polysaccharide.

20. The endoprosthesis of claim 19, wherein the polysaccharide is a non-ionic polysaccharide.

21. The endoprosthesis of claim 19, wherein the polysaccharide is pullulan.

22. The endoprosthesis of claim 18, wherein the surface has a Sdr between 120 and 200.

23. The endoprosthesis of claim 18, wherein the endoprosthesis is bioerodible.

24. The endoprosthesis of claim 18, wherein the endoprosthesis is a stent.