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CD34 stem cell-related methods and compositions

  • US 7,998,472 B2
  • Filed: 05/20/2008
  • Issued: 08/16/2011
  • Est. Priority Date: 05/24/2007
  • Status: Active Grant
First Claim
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1. A method for treating a subject afflicted with a tumor comprising introducing into the subject'"'"'s bloodstream a therapeutically effective number of genetically modified CD34

  • stem cells, wherein (a) each of the genetically modified CD34

    stem cells contains an exogenous nucleic acid comprising (i) a cytotoxic protein-encoding region operably linked to (ii) a promoter or promoter/enhancer combination, whereby the cytotoxic protein is selectively expressed when the genetically modified CD34

    stem cells come into proximity with, and differentiate into endothelial-like cells in proximity with, tumor tissue undergoing angiogenesis, directly and/or indirectly causing tumor tissue death, and (b) the introduction of the genetically modified CD34

    stem cells is not preceded, accompanied or followed by myeloablation.

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