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Encapsulated vaccines for the oral vaccination and boostering of fish and other animals

  • US 7,998,502 B2
  • Filed: 03/24/2009
  • Issued: 08/16/2011
  • Est. Priority Date: 03/24/2008
  • Status: Active Grant
First Claim
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1. A composition for oral administration to an animal for intestinal delivery of a pharmaceutically active agent, said composition comprising:

  • a) at least one bioadhesive polymer selected from the group consisting of chitosan, hyaluronic acid, cationic guar, and combinations thereof;

    wherein the bioadhesive polymer is present at a concentration of between 1% and 10%;

    b) at least one oligosaccharide selected from the group consisting of inulin, fructooligosaccharide and dextrin, wherein the oligosaccharide is present at a concentration of between 1% and 50%;

    c) at least one mediating compound having both hydrophilic and lipophilic properties, wherein the mediating compound comprises an emulsifier/sugar complex containing 0.5 to 12.5% w/w emulsifier and 5-30% w/w sugar, and d) a pharmaceutically active agent.

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