Aptamers that bind thrombin with high affinity
First Claim
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1. An aptamer that binds to thrombin comprising the following nucleic acid sequence:
- CCTAGGTTGGGTAGGGTGGTGG (SEQ ID NO
441).
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Abstract
The invention provides aptamers capable of binding to thrombin useful as therapeutics for and diagnostics of coagulation related disorders and/or other diseases or disorders in which thrombin has been implicated. The invention further provides materials and methods for the administration of aptamers capable of binding to thrombin.
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30 Claims
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1. An aptamer that binds to thrombin comprising the following nucleic acid sequence:
- CCTAGGTTGGGTAGGGTGGTGG (SEQ ID NO
441). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
- CCTAGGTTGGGTAGGGTGGTGG (SEQ ID NO
Specification