Combinations containing a 4-acylaminopyridine derivative

• US 7,998,971 B2
• Filed: 06/21/2007
• Issued: 08/16/2011
• Est. Priority Date: 09/08/2006
• Status: Expired due to Fees

• Current Assignee: BrainCells Inc.
• Original Assignee: BrainCells Inc.
• Inventors: Treuner, Kai, Morse, Andrew, Lorrain, Kym I., Carter, Todd A., Barlow, Carrolee
• Primary Examiner(s): Chong; Yong
• Assistant Examiner(s): KAROL, JODY LYNN
• Application Number:
  US11/766,721
• Publication Number:
  US 20080064671A1
• Time in Patent Office: 1,517 Days
• Field of Search: None
• US Class Current: 514/292
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/4355 the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/14 for treating abnormal movements, e.g. chorea, dyskinesia
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 25/30 for treating abuse or dependence
• CPC Class Codes: A61P 25/32 Alcohol-abuse
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The instant disclosure describes compositions and methods for treating diseases and conditions of the central and peripheral nervous system. The disclosure includes compositions and methods based on use of a 4-acylaminopyridine derivative in combination with one or more other neurogenic agents. One 4-acylaminopyridine derivative is MKC-231.

Claims

1. A composition comprising a 4-acylaminopyridine compound in synergistic combination with an active agent, wherein the 4 -acylaminopyridine compound is 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)acetoamide (MKC-231), or an isomer thereof and the active agent is modafinil, or an isomer thereof.

2. The composition of claim 1, wherein the effective dosage of the 4-acylaminopyridine compound and the active agent in combination is synergistic when compared to the effective dosage of the compound or active agent when used alone.

3. The composition of claim 1, wherein the combination is in a single formulation.

4. The composition of claim 1 wherein the 4-acylaminopyridine compound and the active agent are contained in the same unit dosage form.

5. A method of treating depression in a subject in need thereof comprising administering the composition of claim 1 to said subject.